Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 19, 2024
Globally,
cardiovascular
diseases
(CVDs)
remain
the
leading
cause
of
death,
and
their
prevention
treatment
continue
to
face
major
challenges.
Oxylipins,
as
novel
circulating
markers
disease,
are
crucial
mediators
linking
risk
factors
such
inflammation
platelet
activation,
they
play
an
important
role
in
unraveling
pathogenesis
therapeutic
mechanisms.
Chinese
herbal
medicine
plays
adjuvant
diseases,
which
has
predominantly
focused
on
key
pathways
classic
lipids,
inflammation,
oxidative
stress
elucidate
mechanisms
diseases.
However,The
regulatory
effect
traditional
oxylipins
remains
largely
unknown.
With
increasing
number
recent
reports
regulation
by
it
is
necessary
comprehensively
from
perspective
oxylipins.
This
approach
not
only
benefits
further
research
targets
medicine,
but
also
brings
new
perspectives
Nutrients,
Год журнала:
2024,
Номер
16(14), С. 2220 - 2220
Опубликована: Июль 11, 2024
Non-alcoholic
fatty
liver
disease
(NAFLD)
is
a
common
long-lasting
that
affects
millions
of
people
around
the
world.
It
best
identified
with
hepatic
fat
build-up
ultimately
leads
to
inflammation
and
damage.
The
classification
nomenclature
NAFLD
have
long
been
controversial
topic,
until
2020
when
group
international
experts
recommended
substituting
MAFLD
(metabolic
dysfunction-associated
FLD).
was
then
terminologically
complemented
in
2023
by
altering
it
MASLD,
i.e.,
metabolic
steatotic
(MASLD).
Both
MASLD
terminologies
comprise
element
disorder,
as
they
offer
diagnostic
benchmarks
are
embedded
risk
factors
underlie
disease.
(as
multisystemic
disease)
provides
comprehensive
definition
includes
larger
population
patients
who
at
morbidity
mortality,
well
adverse
cardiovascular
diabetes
outcomes.
highlights
risks
lean
or
normal
weight
individuals,
factor
has
not
accentuated
discussed
previous
guidelines.
Novel
antihyperglycemic
agents,
anti-hyperlipidemic
drugs,
lifestyle
modifications,
nutritional
interventions,
exercise
therapies
extensively
studied
MASLD.
Nutrition
plays
vital
role
managing
both
conditions,
where
centralizing
on
diet
rich
whole
vegetables,
fruits,
foods,
healthy
fats,
proteins,
specific
nutrients
(e.g.,
omega-3
acids
fibers)
can
improve
insulin
resistance
reduce
inflammation.
Thus,
essential
understand
nutrition
these
conditions
work
develop
an
individualized
plan
for
optimal
health.
This
review
discusses
prevention
strategies
NAFLD/MAFLD/MASLD
management,
particular
attention
correction.
Food & Function,
Год журнала:
2024,
Номер
15(8), С. 4475 - 4489
Опубликована: Янв. 1, 2024
The
fermented
yogurt
of
Lacticaseibacillus
rhamnosus
HF01
alters
obese
mice
gut
microbiota
by
boosting
beneficial
flora
and
butyric
acid,
activates
AMPK
to
regulate
lipid
metabolism,
combating
obesity.
Abstract
Traditional
Chinese
medicine
(TCM)
has
been
widely
used
for
several
centuries
metabolic
diseases,
including
non-alcoholic
fatty
liver
disease
(NAFLD).
At
present,
NAFLD
become
the
most
prevalent
form
of
chronic
worldwide
and
can
progress
to
steatohepatitis
(NASH),
cirrhosis,
even
hepatocellular
carcinoma.
However,
there
is
still
a
lack
effective
treatment
strategies
in
Western
medicine.
The
development
driven
by
multiple
mechanisms,
genetic
factors,
insulin
resistance,
lipotoxicity,
mitochondrial
dysfunction,
endoplasmic
reticulum
stress,
inflammation,
gut
microbiota
dysbiosis,
adipose
tissue
dysfunction.
Currently,
certain
drugs,
sensitizers,
statins,
vitamin
E,
ursodeoxycholic
acid
betaine,
are
proven
be
beneficial
clinical
NAFLD.
Due
its
complex
pathogenesis,
personalized
that
integrates
various
mechanisms
may
provide
better
benefits
patients
with
holistic
view
syndrome
differentiation
TCM
have
advantages
treating
NAFLD,
which
similar
principles
In
TCM,
primarily
classified
into
five
types
based
on
experience.
It
located
closely
related
spleen
kidney
functions.
due
multi-component
characteristics
traditional
medicine,
application
considerably
limited.
this
review,
we
summarize
advances
pathogenesis
drawn
from
both
perspectives.
We
highlight
complementary
should
receive
increased
attention
prevention
Frontiers in Nutrition,
Год журнала:
2024,
Номер
11
Опубликована: Авг. 8, 2024
Radish
seed
is
a
functional
food
with
many
beneficial
health
effects.
Glucosinolates
are
characteristic
components
in
radish
that
can
be
transformed
into
bioactive
isothiocyanates
by
gut
microbiota.
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 22, 2025
Obesity
rates
are
rising
globally
and
have
become
a
major
public
health
issue.
Recent
research
emphasizes
the
bidirectional
communication
between
gut
microbiota
mitochondrial
function
in
obesity
development.
Gut
regulates
energy
metabolism
through
metabolites
that
impact
processes,
such
as
oxidative
phosphorylation,
biogenesis,
autophagy.
In
turn,
alterations
homeostasis.
Traditional
Chinese
medicine
(TCM),
which
encompasses
TCM
formulas
of
botanical
drugs,
employs
holistic
integrative
approach
shows
promise
regulating
microbiota-mitochondrial
crosstalk.
This
review
systematically
explores
intricate
interactions
function,
underscoring
their
crosstalk
critical
mechanistic
axis
pathogenesis.
Furthermore,
it
highlights
potential
developing
innovative,
targeted
interventions,
paving
way
for
personalized
approaches
treatment
precise
modulation
interactions,
offering
more
effective
individualized
therapeutic
options.
