Heliyon,
Год журнала:
2024,
Номер
10(11), С. e32526 - e32526
Опубликована: Июнь 1, 2024
ObjectiveBased
on
network
pharmacology
and
experimental
validation,
this
study
aimed
to
screen
the
potential
targets
of
Liuwei
Dihuang
decoction
(LW)
against
mild
cognitive
impairment
(MCI).MethodsBased
pharmacology,
preliminarily
explored
molecular
mechanisms
LW
in
treatment
MCI.
The
results
showed
that
mechanism
action
MCI
may
be
related
cAMP
pathway.
Then,
an
aging
cell
animal
model
was
established
further
verify
its
mechanism.ResultsA
total
23
active
ingredients
were
identified
LW.
In
addition,
through
pharmacological
analysis,
we
found
22
anti-MCI
LW,
which
alisol
B
had
most
significant
effect,
predicted
pathway
by
improve
signaling
Further
vivo
vitro
experiments
confirmed
can
alleviate
dysfunction
mice
reduce
D-galactose-induced
senescent
cells,
activation
cAMP/PKA/CREB
pathway.ConclusionThis
traditional
Chinese
medicine
formula
play
a
role
improving
regulating
pathway,
provides
reference
for
clinical
research
effect
mechanism.
Based
(MCI).
A
This
Cancer Biology and Medicine,
Год журнала:
2023,
Номер
unknown, С. 1 - 19
Опубликована: Дек. 23, 2023
Hepatocellular
carcinoma
(HCC)
is
a
prevalent
and
aggressive
liver
malignancy.
The
interplay
between
bile
acids
(BAs)
the
gut
microbiota
has
emerged
as
critical
factor
in
HCC
development
progression.
Under
normal
conditions,
BA
metabolism
tightly
regulated
through
bidirectional
microorganisms
BAs.
plays
role
metabolism,
BAs
are
endogenous
signaling
molecules
that
help
maintain
intestinal
homeostasis.
Of
note,
dysbiotic
changes
during
pathogenesis
cancer
can
disrupt
homeostasis,
thereby
leading
to
inflammation
fibrosis,
ultimately
contributing
development.
Therefore,
understanding
intricate
crucial
for
elucidating
mechanisms
underlying
hepatocarcinogenesis.
In
this
review,
we
comprehensively
explore
roles
functions
of
with
focus
on
interactions
HCC.
Additionally,
therapeutic
strategies
targeting
discussed,
including
use
agonists/antagonists,
probiotic/prebiotic
dietary
interventions,
fecal
transplantation,
engineered
bacteria.
summary,
complex
BA-microbiota
crosstalk
provide
valuable
insights
into
facilitate
innovative
approaches
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 25, 2025
The
gut
microbiota,
a
complex
microbial
ecosystem
closely
connected
to
the
liver
via
portal
vein,
has
emerged
as
critical
regulator
of
health
and
disease.
Numerous
studies
have
underscored
its
role
in
onset
progression
disorders,
including
alcoholic
disease,
metabolic
dysfunction-associated
steatotic
disease
(MASLD),
steatohepatitis
(MASH),
fibrosis,
cirrhosis,
hepatocellular
carcinoma
(HCC).
This
review
provides
comprehensive
overview
current
insights
into
influence
microbiota
on
HCC
progression,
particularly
effects
immune
cells
within
tumor
microenvironment
(TME).
Furthermore,
we
explore
potential
microbiota-targeted
interventions,
such
antibiotics,
probiotics,
prebiotics,
fecal
transplantation
(FMT),
modulate
response
improve
outcomes
immunotherapy
HCC.
By
synthesizing
from
recent
studies,
this
aims
highlight
microbiota-based
strategies
that
may
enhance
outcomes,
advancing
personalized
approaches
treatment.
ABSTRACT
Background
The
relationship
between
hepatocellular
carcinoma
(HCC)
and
gut
microbiota
has
gained
attention
for
its
impact
on
HCC
immunotherapy.
Methods
Key
microbial
metabolites,
including
bile
acids,
toll‐like
receptor
4,
short‐chain
fatty
bacterial
toxins,
contribute
to
progression
influence
immune
responses
through
the
gut‐liver
axis.
As
checkpoint
inhibitors
(ICIs)
become
common
in
treatment,
modulating
offers
new
strategies
enhance
ICIs
efficacy.
However,
individual
differences
composition
introduce
challenges,
with
some
patients
showing
resistance
ICIs.
Results
This
review
summarizes
latest
findings
role
of
explores
emerging
therapeutic
approaches,
fecal
transplantation,
probiotics,
antibiotics,
natural
compounds.
Conclusions
focus
is
translating
these
insights
into
personalized
medicine
optimize
improve
treatment
outcomes.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 9, 2024
The
gut
microbiota
offers
numerous
benefits
to
the
human
body,
including
promotion
of
nutrient
absorption,
participation
in
metabolic
processes,
and
enhancement
immune
function.
Recent
studies
have
introduced
concept
gut-organ
axis,
which
encompasses
interactions
such
as
gut-brain
gut-liver
gut-lung
axis.
This
underscores
complex
interplay
between
various
organs
tissues,
brain,
heart,
lungs,
liver,
kidneys,
muscles,
bones.
Growing
evidence
indicates
that
can
influence
onset
progression
multi-organ
system
diseases
through
their
effects
on
Traditional
Chinese
medicine
has
demonstrated
significant
efficacy
regulating
gastrointestinal
system,
leveraging
its
unique
advantages.
Considerable
advancements
been
made
understanding
role
axis
within
mechanisms
action
traditional
medicine.
review
aims
elucidate
roles
health,
explore
potential
connections
microbiota,
examine
therapeutic
microbiota-gut-organ
Furthermore,
addresses
limitations
challenges
present
current
research
while
proposing
directions
for
future
investigations
this
area.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Июль 16, 2024
Liver
cirrhosis
arises
from
liver
fibrosis
and
necroinflammation
caused
by
various
mechanisms
of
hepatic
injury.
It
is
a
prevalent
condition
in
clinical
practice
characterized
hepatocellular
dysfunction,
portal
hypertension,
associated
complications.
Despite
its
common
occurrence,
the
etiology
pathogenesis
remain
incompletely
understood,
posing
significant
health
threat.
Effective
prevention
onset
progression
paramount
medical
research.
Symptoms
often
include
discomfort
area,
while
complications
such
as
sarcopenia,
encephalopathy,
ascites,
upper
gastrointestinal
bleeding,
infection
can
arise.
While
efficacy
Western
medicine
treating
uncertain,
Chinese
offers
distinct
advantages.
This
review
explores
advancements
treatment
encompassing
non-pharmacological
pharmacological
modalities.
interventions,
including
decoctions,
patent
medicines,
acupuncture,
exhibit
notable
reversal
offer
improved
prognoses.
Nowadays,
combination
also
has
considerable
advantages,
which
worthy
further
research
promotion.
Standardized
protocols
based
on
these
findings
hold
implications.
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Май 19, 2025
The
gut-liver
axis
is
a
multifaceted
system
where
chemical
and
biological
interactions
between
gut
microbiota-derived
metabolites
the
liver
significantly
influence
development
progression
of
hepatocellular
carcinoma
Metabolites
such
as
lipopolysaccharide
(LPS),
bile
acids
(BAs),
short-chain
fatty
(SCFAs)
act
mediators
that
modulate
tumor
microenvironment
through
immune
cell
stromal
activation,
influencing
growth
metastasis.
Changes
in
microbiota
composition
alter
these
signaling
pathways,
providing
opportunities
for
therapeutic
interventions.
Strategies
prebiotics,
probiotics,
natural
product-based
small
molecules
have
shown
promise
modulating
axis.
Advanced
multi-omics,
bioinformatics
tools,
coupled
with
vitro
models
like
organoids,
unveiled
intricate
molecular
interactions,
offering
insights
into
novel
targets.
Future
research
should
focus
on
delineating
pharmacological
immunological
mechanisms
within
axis,
developing
personalized
strategies,
translating
findings
clinical
applications.
