Bile acids, gut microbiota, and therapeutic insights in hepatocellular carcinoma

Cancer Biology and Medicine, Journal Year: 2023, Volume and Issue: unknown, P. 1 - 19

Published: Dec. 23, 2023

Hepatocellular carcinoma (HCC) is a prevalent and aggressive liver malignancy. The interplay between bile acids (BAs) the gut microbiota has emerged as critical factor in HCC development progression. Under normal conditions, BA metabolism tightly regulated through bidirectional microorganisms BAs. plays role metabolism, BAs are endogenous signaling molecules that help maintain intestinal homeostasis. Of note, dysbiotic changes during pathogenesis cancer can disrupt homeostasis, thereby leading to inflammation fibrosis, ultimately contributing development. Therefore, understanding intricate crucial for elucidating mechanisms underlying hepatocarcinogenesis. In this review, we comprehensively explore roles functions of with focus on interactions HCC. Additionally, therapeutic strategies targeting discussed, including use agonists/antagonists, probiotic/prebiotic dietary interventions, fecal transplantation, engineered bacteria. summary, complex BA-microbiota crosstalk provide valuable insights into facilitate innovative approaches

Language: Английский

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Phenanthrene-induced hyperuricemia with intestinal barrier damage and the protective role of theabrownin: Modulation by gut microbiota-mediated bile acid metabolism

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 949, P. 174923 - 174923

Published: July 22, 2024

Language: Английский

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Structural characterization of an acid-extracted polysaccharide from Suillus luteus and the regulatory effects on intestinal flora metabolism in tumor-bearing mice

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 280, P. 136137 - 136137

Published: Sept. 28, 2024

Language: Английский

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Modulatory effects of traditional Chinese medicines on gut microbiota and the microbiota-gut-x axis

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 9, 2024

The gut microbiota offers numerous benefits to the human body, including promotion of nutrient absorption, participation in metabolic processes, and enhancement immune function. Recent studies have introduced concept gut-organ axis, which encompasses interactions such as gut-brain gut-liver gut-lung axis. This underscores complex interplay between various organs tissues, brain, heart, lungs, liver, kidneys, muscles, bones. Growing evidence indicates that can influence onset progression multi-organ system diseases through their effects on Traditional Chinese medicine has demonstrated significant efficacy regulating gastrointestinal system, leveraging its unique advantages. Considerable advancements been made understanding role axis within mechanisms action traditional medicine. review aims elucidate roles health, explore potential connections microbiota, examine therapeutic microbiota-gut-organ Furthermore, addresses limitations challenges present current research while proposing directions for future investigations this area.

Language: Английский

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α-GalCer regulates acute stress-induced steroidogenesis by modulating lipid metabolism in female BALB/c mice

Psychoneuroendocrinology, Journal Year: 2025, Volume and Issue: unknown, P. 107481 - 107481

Published: May 1, 2025

Language: Английский

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Gut Microbiota and Hepatocellular Carcinoma: Metabolic Products and Immunotherapy Modulation

Cancer Medicine, Journal Year: 2025, Volume and Issue: 14(9)

Published: May 1, 2025

ABSTRACT Background The relationship between hepatocellular carcinoma (HCC) and gut microbiota has gained attention for its impact on HCC immunotherapy. Methods Key microbial metabolites, including bile acids, toll‐like receptor 4, short‐chain fatty bacterial toxins, contribute to progression influence immune responses through the gut‐liver axis. As checkpoint inhibitors (ICIs) become common in treatment, modulating offers new strategies enhance ICIs efficacy. However, individual differences composition introduce challenges, with some patients showing resistance ICIs. Results This review summarizes latest findings role of explores emerging therapeutic approaches, fecal transplantation, probiotics, antibiotics, natural compounds. Conclusions focus is translating these insights into personalized medicine optimize improve treatment outcomes.

Language: Английский

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Liver cirrhosis: current status and treatment options using western or traditional Chinese medicine

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: July 16, 2024

Liver cirrhosis arises from liver fibrosis and necroinflammation caused by various mechanisms of hepatic injury. It is a prevalent condition in clinical practice characterized hepatocellular dysfunction, portal hypertension, associated complications. Despite its common occurrence, the etiology pathogenesis remain incompletely understood, posing significant health threat. Effective prevention onset progression paramount medical research. Symptoms often include discomfort area, while complications such as sarcopenia, encephalopathy, ascites, upper gastrointestinal bleeding, infection can arise. While efficacy Western medicine treating uncertain, Chinese offers distinct advantages. This review explores advancements treatment encompassing non-pharmacological pharmacological modalities. interventions, including decoctions, patent medicines, acupuncture, exhibit notable reversal offer improved prognoses. Nowadays, combination also has considerable advantages, which worthy further research promotion. Standardized protocols based on these findings hold implications.

Language: Английский

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Bacteroides uniformis Ameliorates Carbohydrate and Lipid Metabolism Disorders in Diabetic Mice by Regulating Bile Acid Metabolism via the Gut–Liver Axis

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(8), P. 1015 - 1015

Published: Aug. 1, 2024

Background: Type 2 diabetes mellitus (T2DM) is a metabolic syndrome characterized by chronic inflammation, insulin resistance, and islet cell damage. The prevention of T2DM its associated complications an urgent public health issue that affects hundreds millions people globally. Numerous studies suggest disturbances in gut metabolites are important driving forces for the pathogenesis diabetes. However, functions mechanisms action most commensal bacteria remain largely unknown. Methods: quantification bile acids (BAs) fecal samples was performed using ultra-performance liquid chromatography–tandem mass spectrometer (UPLC-MS/MS). anti-diabetic effects Bacteroides uniformis (B. uniformis) cholic acid (CA) chenodeoxycholic (CDCA) were assessed mice induced streptozocin (STZ) plus high-fat diet (HFD). Results: We found abundance B. feces contents CA CDCA significantly downregulated mice. diminished diabetic individuals this bacterium sufficient to promote production BAs. Colonization intragastric gavage effectively improved disorder glucose lipid metabolism inhibiting gluconeogenesis lipolysis liver. hepatic acting on Takeda G protein-coupled receptor 5 (TGR5)/adenosine monophosphate-activated protein kinase (AMPK) signaling pathway since knockdown TGR5 minimized benefit CDCA. Furthermore, we screened natural product—vaccarin (VAC)—that exhibited promoting growth vitro vivo. Gut microbiota pre-depletion abolished favorable VAC Conclusions: These data supplementation may be promising avenue ameliorate linking

Language: Английский

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Emerging insights into the gut microbiota as a key regulator of immunity and response to immunotherapy in hepatocellular carcinoma

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 25, 2025

The gut microbiota, a complex microbial ecosystem closely connected to the liver via portal vein, has emerged as critical regulator of health and disease. Numerous studies have underscored its role in onset progression disorders, including alcoholic disease, metabolic dysfunction-associated steatotic disease (MASLD), steatohepatitis (MASH), fibrosis, cirrhosis, hepatocellular carcinoma (HCC). This review provides comprehensive overview current insights into influence microbiota on HCC progression, particularly effects immune cells within tumor microenvironment (TME). Furthermore, we explore potential microbiota-targeted interventions, such antibiotics, probiotics, prebiotics, fecal transplantation (FMT), modulate response improve outcomes immunotherapy HCC. By synthesizing from recent studies, this aims highlight microbiota-based strategies that may enhance outcomes, advancing personalized approaches treatment.

Language: Английский

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Potential of natural products and gut microbiome in tumor immunotherapy

Chinese Medicine, Journal Year: 2024, Volume and Issue: 19(1)

Published: Nov. 20, 2024

Abstract Immunotherapy is a novel treatment approach for malignant tumors, which has opened new journey of anti-tumor therapy. Although some patients will show positive response to immunotherapy, unfortunately, most and cancer types do not achieve an ideal immunotherapy. Therefore, it urgent search the pathogenesis sensitized This review indicates that Fusobacterium nucleatum , Coprobacillus cateniformis Akkermansia muciniphila Bifidobacterium among others, as well intestinal microbial metabolites are closely associated with resistance While natural products pectin inulin jujube anthocyanins ginseng polysaccharides diosgenin camu-camu Inonotus hispidus (Bull).Fr. P. Karst Icariside I Safflower yellow Ganoderma lucidum Ginsenoside Rk3 other Chinese native medicinal compound prescriptions boost their efficacy immunotherapy through regulation microbiota metabolites. However, current research mainly focuses on intestinal, liver, lung cancer. In future, could be viable option treating such pancreatic, esophageal, gastric malignancies, via sensitizing Besides, application characteristics different types, sources in immune scenarios also need further clarified development future immunotherapy-related studies.

Language: Английский

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