Buyang Huanwu decoction promotes gray and white matter remyelination by inhibiting Notch signaling activation in the astrocyte and microglia after ischemic stroke

Journal of Ethnopharmacology, Год журнала: 2025, Номер unknown, С. 119440 - 119440

Опубликована: Фев. 1, 2025

Язык: Английский

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The role of astrocyte metabolic reprogramming in ischemic stroke (Review)

International Journal of Molecular Medicine, Год журнала: 2025, Номер 55(3)

Опубликована: Янв. 21, 2025

Ischemic stroke, a leading cause of disability and mortality worldwide, is characterized by the sudden loss blood flow in specific area brain. Intravenous thrombolysis with recombinant tissue plasminogen activator only approved pharmacological treatment for acute ischemic stroke; however, aforementioned has significant clinical limitations, thus there an urgent need development novel mechanisms therapeutic strategies stroke. Astrocytes, abundant versatile cells central nervous system, offer crucial support to neurons nutritionally, structurally physically. They also contribute blood‑brain barrier formation regulate neuronal extracellular ion concentrations. Accumulated evidence revealed involvement astrocytes regulation host neurotransmitter metabolism, immune response repair, different metabolic characteristics can process suggesting that targeted astrocyte reprogramming may prognosis In present review, current understanding multifaceted along its regulatory factors pathways, as well promote polarization balance, which hold promise immunometabolism‑targeted therapies were summarized.

Язык: Английский

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Glial polarization in neurological diseases: Molecular mechanisms and therapeutic opportunities

Ageing Research Reviews, Год журнала: 2024, Номер 104, С. 102638 - 102638

Опубликована: Дек. 12, 2024

Язык: Английский

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Targeting astrocytes polarization after spinal cord injury: a promising direction

Frontiers in Cellular Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Окт. 16, 2024

Spinal cord injury (SCI) is a serious neurological that causes severe trauma to motor and sensory functions. Although long considered incurable, recent research has brought new hope for functional recovery from SCI. After SCI, astrocytes are activated into many polarization states. Here we discuss the two most important classical phenotypes: ‘A1’ neurotoxic phenotype ‘A2’ neuroprotective phenotype, with A1 being impeding neurorecovery, A2 neuroprotective. This paper discusses changes in astrocyte responsiveness after SCI pros cons of their It also elucidates feasibility as therapeutic target neuroprotection. In future, multiple intervention strategies targeting expected gain wider clinical application, ultimately improving motor-sensory function quality life patients.

Язык: Английский

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Astrocyte heterogeneity in ischemic stroke: Molecular mechanisms and therapeutic targets

Neurobiology of Disease, Год журнала: 2025, Номер unknown, С. 106885 - 106885

Опубликована: Март 1, 2025

Язык: Английский

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Buyang Huanwu decoction improves motor function by enhancing internal capsule reorganization through inhibiting Notch signaling after ischemic stroke

Journal of Ethnopharmacology, Год журнала: 2025, Номер unknown, С. 119812 - 119812

Опубликована: Апрель 1, 2025

Язык: Английский

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Icaritin Promotes Brain Functional Rehabilitation in Ischemic Stroke Rats by Regulating Astrocyte Activation and Polarization Via GPER

Free Radical Biology and Medicine, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Язык: Английский

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Buyang huanwu decoction alleviates stroke-induced immunosuppression in MCAO mice by reducing splenic T cell apoptosis triggered by AIM2 inflammasome

Journal of Ethnopharmacology, Год журнала: 2024, Номер 333, С. 118474 - 118474

Опубликована: Июнь 19, 2024

Язык: Английский

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Buyang Huanwu Decoction Alleviates Stroke-Induced Immunosuppression in Mcao Mice by Reducing Splenic T Cell Apoptosis Triggered by Aim2 Inflammasome

Опубликована: Янв. 1, 2024

Язык: Английский

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Global research hotspots and trends of Buyang huanwu decoction: A visual analysis of the literature based on CiteSpace

Medicine, Год журнала: 2024, Номер 103(45), С. e40457 - e40457

Опубликована: Ноя. 8, 2024

Buyang huanwu decoction (BYHWD) has shown significant clinical efficacy in the treatment of several diseases, particularly stroke. However, bibliometric research not been comprehensive.

Язык: Английский

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