Bletilla ochracea Schltr. protects against ethanol-induced acute gastric ulcers by alleviating oxidative stress and inflammation and modulating gut microbiota
Fitoterapia,
Год журнала:
2025,
Номер
181, С. 106397 - 106397
Опубликована: Янв. 21, 2025
Язык: Английский
The application of traditional Chinese medicine polysaccharides in wound healing: A review
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
304, С. 140993 - 140993
Опубликована: Фев. 12, 2025
Язык: Английский
Isomeric 2-isobutylmalate derivatives with anti-pulmonary fibrosis effects from the leaves of Bletilla striata via LC-MS/MS-based molecular networking
Bioorganic Chemistry,
Год журнала:
2025,
Номер
159, С. 108351 - 108351
Опубликована: Март 8, 2025
Язык: Английский
Bletilla striata polysaccharide induces autophagy through PI3K/AKT signaling pathway to promote the survival of cross-boundary flap in rats
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Март 10, 2025
Introduction
Distal
flap
necrosis
is
a
common
problem
in
transplantation.
Bletilla
striata
polysaccharide
(BSP)
the
main
medicinal
component
of
traditional
Chinese
medicine
striata.
The
purpose
this
study
was
to
investigate
mechanism
BSP
promoting
survival.
Methods
control
group,
low,
medium
and
high
dose
groups,
+
autophagy
inhibitor
3-methyladenine
(3-MA)
group
were
designed
establish
model
cross-boundary
rat
back.
After
7
days
postoperative
administration,
samples
taken.
Results
optimal
determined
be
250
mg/kg/d
according
survival
rate
flap,
microvessel
density,
intra-arterial
diameter,
expression
vascular-related
protein
pharmacological
toxicity.
By
detecting
level
autophagy-related
proteins,
it
found
that
could
activate
autophagy.
blocked,
therapeutic
effect
reversed.
In
addition,
activated
PI3K/AKT
signaling
pathway.
Discussion
Studies
have
shown
induces
by
activating
pathway,
thereby
angiogenesis
improving
flap.
Язык: Английский
Polysaccharides from Medicinal Plants: Bridging Ancestral Knowledge with Contemporary Science
Plants,
Год журнала:
2024,
Номер
13(13), С. 1721 - 1721
Опубликована: Июнь 21, 2024
Plants
are
a
core
part
of
cultural
identity,
as
diet,
decorations,
ceremonies,
or
medicinal
agents.
Empirical
knowledge
regarding
plants
and
their
healing
potential
has
existed
worldwide
for
centuries.
With
the
advance
science
technology,
not
only
is
refinement
such
sources
isolation
specific
compounds
possible,
but
these
can
also
be
characterized
based
on
natural
occurrence.
Besides
importance
plant
metabolism
structure,
polysaccharides
have
been
demonstrated
to
substantial
positive
human
health
impacts
inflammation,
metabolism,
oxidative
stress,
others.
As
an
inherent
cell
walls,
many
from
herbs,
fructans,
glucans,
pectins,
extracted
analyzed
structure
function.
However,
review
summarizing
significant
portion
studies
was
still
unavailable.
This
helps
fill
gap
between
polysaccharide
bioactivity,
matrix
sources,
focusing
historical
usage.
Язык: Английский
Self-assembled ROS-triggered Bletilla striata polysaccharide-releasing hydrogel dressing for inflammation-regulation and enhanced tissue-healing
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
278, С. 135194 - 135194
Опубликована: Сен. 10, 2024
Язык: Английский
Anti-pulmonary fibrosis activity analysis of methyl rosmarinate obtained from Salvia castanea Diels f. tomentosa Stib. using a scalable process
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Июнь 4, 2024
Pulmonary
fibrosis
is
a
progressive,
irreversible,
chronic
interstitial
lung
disease
associated
with
high
morbidity
and
mortality
rates.
Current
clinical
drugs,
while
effective,
do
not
reverse
or
cure
pulmonary
have
major
side
effects,
there
are
urgent
needs
to
develop
new
anti-pulmonary
medicine,
corresponding
industrially
scalable
process
as
well.
Salvia
castanea
Diels
f.
tomentosa
Stib.,
unique
herb
in
Nyingchi,
Xizang,
China,
variant
of
S.
.
its
main
active
ingredient
rosmarinic
acid
(RA),
which
can
be
used
prepare
methyl
rosmarinate
(MR)
greater
drug
potential.
This
study
presented
an
for
the
preparation
MR,
includes
steps
such
polyamide
resin
chromatography,
crystallization
esterification,
using
Stib.
starting
material
structure
product
was
verified
by
NMR
technology.
The
effects
MR
were
further
investigated
vivo
vitro
Results
showed
that
this
easily
obtain
high-purity
RA
attenuated
bleomycin-induced
mice.
In
,
could
effectively
inhibit
TGF-β1-induced
proliferation
migration
mouse
fibroblasts
L929
cells,
promote
cell
apoptosis,
decrease
extracellular
matrix
accumulation
thereby
suppressing
progressive
fibrosis.
anti-fibrosis
effect
stronger
than
prodrug
RA.
Further
confirmed
retard
down-regulating
phosphorylation
TGF-β1/Smad
MAPK
signaling
pathways.
These
results
suggest
has
potential
therapeutic
implications
fibrosis,
establishment
technology
ensures
development
medicine.
Язык: Английский