Bletilla ochracea Schltr. protects against ethanol-induced acute gastric ulcers by alleviating oxidative stress and inflammation and modulating gut microbiota

Fitoterapia, Journal Year: 2025, Volume and Issue: 181, P. 106397 - 106397

Published: Jan. 21, 2025

Language: Английский

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The application of traditional Chinese medicine polysaccharides in wound healing: A review

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 304, P. 140993 - 140993

Published: Feb. 12, 2025

Language: Английский

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Isomeric 2-isobutylmalate derivatives with anti-pulmonary fibrosis effects from the leaves of Bletilla striata via LC-MS/MS-based molecular networking

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 159, P. 108351 - 108351

Published: March 8, 2025

Language: Английский

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Bletilla striata polysaccharide induces autophagy through PI3K/AKT signaling pathway to promote the survival of cross-boundary flap in rats

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 10, 2025

Introduction Distal flap necrosis is a common problem in transplantation. Bletilla striata polysaccharide (BSP) the main medicinal component of traditional Chinese medicine striata. The purpose this study was to investigate mechanism BSP promoting survival. Methods control group, low, medium and high dose groups, + autophagy inhibitor 3-methyladenine (3-MA) group were designed establish model cross-boundary rat back. After 7 days postoperative administration, samples taken. Results optimal determined be 250 mg/kg/d according survival rate flap, microvessel density, intra-arterial diameter, expression vascular-related protein pharmacological toxicity. By detecting level autophagy-related proteins, it found that could activate autophagy. blocked, therapeutic effect reversed. In addition, activated PI3K/AKT signaling pathway. Discussion Studies have shown induces by activating pathway, thereby angiogenesis improving flap.

Language: Английский

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Polysaccharides from Medicinal Plants: Bridging Ancestral Knowledge with Contemporary Science

Plants, Journal Year: 2024, Volume and Issue: 13(13), P. 1721 - 1721

Published: June 21, 2024

Plants are a core part of cultural identity, as diet, decorations, ceremonies, or medicinal agents. Empirical knowledge regarding plants and their healing potential has existed worldwide for centuries. With the advance science technology, not only is refinement such sources isolation specific compounds possible, but these can also be characterized based on natural occurrence. Besides importance plant metabolism structure, polysaccharides have been demonstrated to substantial positive human health impacts inflammation, metabolism, oxidative stress, others. As an inherent cell walls, many from herbs, fructans, glucans, pectins, extracted analyzed structure function. However, review summarizing significant portion studies was still unavailable. This helps fill gap between polysaccharide bioactivity, matrix sources, focusing historical usage.

Language: Английский

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Anti-pulmonary fibrosis activity analysis of methyl rosmarinate obtained from Salvia castanea Diels f. tomentosa Stib. using a scalable process

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: June 4, 2024

Pulmonary fibrosis is a progressive, irreversible, chronic interstitial lung disease associated with high morbidity and mortality rates. Current clinical drugs, while effective, do not reverse or cure pulmonary have major side effects, there are urgent needs to develop new anti-pulmonary medicine, corresponding industrially scalable process as well. Salvia castanea Diels f. tomentosa Stib., unique herb in Nyingchi, Xizang, China, variant of S. . its main active ingredient rosmarinic acid (RA), which can be used prepare methyl rosmarinate (MR) greater drug potential. This study presented an for the preparation MR, includes steps such polyamide resin chromatography, crystallization esterification, using Stib. starting material structure product was verified by NMR technology. The effects MR were further investigated vivo vitro Results showed that this easily obtain high-purity RA attenuated bleomycin-induced mice. In , could effectively inhibit TGF-β1-induced proliferation migration mouse fibroblasts L929 cells, promote cell apoptosis, decrease extracellular matrix accumulation thereby suppressing progressive fibrosis. anti-fibrosis effect stronger than prodrug RA. Further confirmed retard down-regulating phosphorylation TGF-β1/Smad MAPK signaling pathways. These results suggest has potential therapeutic implications fibrosis, establishment technology ensures development medicine.

Language: Английский

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Self-assembled ROS-triggered Bletilla striata polysaccharide-releasing hydrogel dressing for inflammation-regulation and enhanced tissue-healing

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 278, P. 135194 - 135194

Published: Sept. 10, 2024

Language: Английский

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