Sustained-Release H2S Nanospheres Regulate the Inflammatory Microenvironment of Wounds, Promote Angiogenesis and Collagen Deposition, and Accelerate Diabetic Wound Healing
ACS Applied Bio Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 18, 2025
Diabetic
wounds
are
blocked
in
the
inflammatory
stage,
growth
factors
degraded,
and
blood
vessels
difficult
to
regenerate,
leading
continuous
necrosis
nonhealing
of
wound.
Hydrogen
sulfide
(H2S)
plays
an
important
role
pathophysiological
process
wound
healing
has
a
long
history
treating
skin
diseases.
Although
salt
solution
is
preferred
donor
exogenous
H2S,
its
rapid
release
rate,
excess
production,
difficulty
accurately
controlling
dose
limit
use.
Herein,
we
developed
H2S
sustained-release
nanospheres
NaHS@MS@LP
for
treatment
diabetic
wounds.
nanosphere
was
composed
NaHS-loaded
mesoporous
silicon
core
DSPE-PEG
liposome
outer
membrane.
When
were
used
treat
rats,
delivered
into
cells
loaded
NaHS
slowly
released
through
hydrolysis,
participating
all
stages
healing.
In
conclusion,
regulated
microenvironment
by
inducing
transformation
macrophages
M2
type
promoted
angiogenesis
collagen
deposition
accelerate
rats.
Our
findings
provide
strategies
chronic
wounds,
including
but
not
limited
Язык: Английский
Syringin inhibits the crosstalk between macrophages and fibroblast-like synoviocytes to treat rheumatoid arthritis via PDE4
Phytomedicine,
Год журнала:
2025,
Номер
138, С. 156401 - 156401
Опубликована: Янв. 18, 2025
Язык: Английский
Pharmacodynamic components and molecular mechanism of Gastrodia elata Blume in treating hypertension: absorbed components, network pharmacology analysis, molecular docking and in vivo experimental verification
Journal of Ethnopharmacology,
Год журнала:
2025,
Номер
unknown, С. 119583 - 119583
Опубликована: Март 1, 2025
Язык: Английский