Sustained-Release H₂S Nanospheres Regulate the Inflammatory Microenvironment of Wounds, Promote Angiogenesis and Collagen Deposition, and Accelerate Diabetic Wound Healing

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Diabetic wounds are blocked in the inflammatory stage, growth factors degraded, and blood vessels difficult to regenerate, leading continuous necrosis nonhealing of wound. Hydrogen sulfide (H2S) plays an important role pathophysiological process wound healing has a long history treating skin diseases. Although salt solution is preferred donor exogenous H2S, its rapid release rate, excess production, difficulty accurately controlling dose limit use. Herein, we developed H2S sustained-release nanospheres NaHS@MS@LP for treatment diabetic wounds. nanosphere was composed NaHS-loaded mesoporous silicon core DSPE-PEG liposome outer membrane. When were used treat rats, delivered into cells loaded NaHS slowly released through hydrolysis, participating all stages healing. In conclusion, regulated microenvironment by inducing transformation macrophages M2 type promoted angiogenesis collagen deposition accelerate rats. Our findings provide strategies chronic wounds, including but not limited

Language: Английский

Syringin inhibits the crosstalk between macrophages and fibroblast-like synoviocytes to treat rheumatoid arthritis via PDE4

Phytomedicine, Journal Year: 2025, Volume and Issue: 138, P. 156401 - 156401

Published: Jan. 18, 2025

Language: Английский

Pharmacodynamic components and molecular mechanism of Gastrodia elata Blume in treating hypertension: absorbed components, network pharmacology analysis, molecular docking and in vivo experimental verification

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119583 - 119583

Published: March 1, 2025

Language: Английский