Glycolytic reprogramming in microglia: A potential therapeutic target for ischemic stroke
Cellular Signalling,
Год журнала:
2024,
Номер
unknown, С. 111466 - 111466
Опубликована: Окт. 1, 2024
Язык: Английский
The impact of glycolysis on ischemic stroke: from molecular mechanisms to clinical applications
Frontiers in Neurology,
Год журнала:
2025,
Номер
16
Опубликована: Янв. 24, 2025
Ischemic
stroke
(IS),
a
leading
cause
of
disability
and
mortality
worldwide,
remains
significant
challenge
due
to
its
complex
pathogenesis.
Glycolysis,
central
metabolic
pathway,
plays
critical
role
in
bridging
the
gap
between
dysfunction
neurological
impairment.
During
ischemic
conditions,
glycolysis
replaces
oxidative
phosphorylation
as
primary
energy
source
for
brain
tissue.
However,
ischemia–reperfusion
state,
neuronal
cells
show
particular
reliance
on
aerobic
glycolysis.
Immune
cells,
such
monocytes,
also
contribute
atheromatous
plaque
formation
thrombi
through
increased
Given
glycolysis’s
involvement
various
pathological
stages
IS,
it
offers
potential
improved
diagnosis,
treatment,
prevention.
This
review
comprehensively
explores
different
phases
addresses
existing
controversies,
discusses
diagnostic
therapeutic
applications.
By
elucidating
intricate
relationship
this
aims
provide
novel
insights
future
research
clinical
advancements.
Язык: Английский
Insight of action mechanism of Astragaloside IV for relieving of cerebral ischemic injury in a rat model of middle cerebral artery occlusion reperfusion via proteomics and network pharmacology
Journal of Natural Medicines,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 10, 2025
Язык: Английский
Shenqi granules enhance recovery from cerebral ischemia-reperfusion injury by modulating tryptophan and tyrosine metabolism and activating NFE2L2/NRF2
Phytomedicine,
Год журнала:
2025,
Номер
140, С. 156623 - 156623
Опубликована: Март 10, 2025
Язык: Английский
Chronic Inflammation Linking Atherosclerosis to Cognitive Impairment: Multi-Target Mechanisms and Therapeutic Advances in Chinese Herbal Medicine
Brain Behavior and Immunity Integrative,
Год журнала:
2025,
Номер
unknown, С. 100122 - 100122
Опубликована: Апрель 1, 2025
Язык: Английский