Insight of action mechanism of Astragaloside IV for relieving of cerebral ischemic injury in a rat model of middle cerebral artery occlusion reperfusion via proteomics and network pharmacology DOI
Xinhua Zhu, Xin Yu,

Xiangwen Kong

et al.

Journal of Natural Medicines, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Language: Английский

Glycolytic reprogramming in microglia: A potential therapeutic target for ischemic stroke DOI
Guangming Zhang,

Anliu Zhao,

Xiaolu Zhang

et al.

Cellular Signalling, Journal Year: 2024, Volume and Issue: unknown, P. 111466 - 111466

Published: Oct. 1, 2024

Language: Английский

Citations

4
The impact of glycolysis on ischemic stroke: from molecular mechanisms to clinical applications DOI Creative Commons
Yingquan Liu,

Peijia Hu,

Hongliang Cheng

et al.

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 24, 2025

Ischemic stroke (IS), a leading cause of disability and mortality worldwide, remains significant challenge due to its complex pathogenesis. Glycolysis, central metabolic pathway, plays critical role in bridging the gap between dysfunction neurological impairment. During ischemic conditions, glycolysis replaces oxidative phosphorylation as primary energy source for brain tissue. However, ischemia–reperfusion state, neuronal cells show particular reliance on aerobic glycolysis. Immune cells, such monocytes, also contribute atheromatous plaque formation thrombi through increased Given glycolysis’s involvement various pathological stages IS, it offers potential improved diagnosis, treatment, prevention. This review comprehensively explores different phases addresses existing controversies, discusses diagnostic therapeutic applications. By elucidating intricate relationship this aims provide novel insights future research clinical advancements.

Language: Английский

Citations

0
Shenqi granules enhance recovery from cerebral ischemia-reperfusion injury by modulating tryptophan and tyrosine metabolism and activating NFE2L2/NRF2 DOI

Hai‐Xin Liu,

Mihi Yang, Yuchang Li

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 140, P. 156623 - 156623

Published: March 10, 2025

Language: Английский

Citations

0
Chronic Inflammation Linking Atherosclerosis to Cognitive Impairment: Multi-Target Mechanisms and Therapeutic Advances in Chinese Herbal Medicine DOI Creative Commons

Rumin Huang,

Xiangrui Zhang, Min Ni

et al.

Brain Behavior and Immunity Integrative, Journal Year: 2025, Volume and Issue: unknown, P. 100122 - 100122

Published: April 1, 2025

Language: Английский

Citations

0
Insight of action mechanism of Astragaloside IV for relieving of cerebral ischemic injury in a rat model of middle cerebral artery occlusion reperfusion via proteomics and network pharmacology DOI
Xinhua Zhu, Xin Yu,

Xiangwen Kong

et al.

Journal of Natural Medicines, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Language: Английский

Citations

0