Factors affecting the composition of the gut microbiota, and its modulation

PeerJ, Год журнала: 2019, Номер 7, С. e7502 - e7502

Опубликована: Авг. 16, 2019

Gut microbiota have important functions in the body, and imbalances composition diversity of those can cause several diseases. The host fosters favorable by releasing specific factors, such as microRNAs, nonspecific antimicrobial peptides, mucus immunoglobulin A that encourage growth types bacteria inhibit others. Diet, antibiotics, age change gut microbiota, many studies shown relationship between disorders diseases reported some ways to modulate balance. In this review, we highlight how shapes its via environmental nutritional factors affect it, it using prebiotics, probiotics, fecal transplantation.

Язык: Английский

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A next-generation beneficial microbe: <i>Akkermansia muciniphila</i>

Journal of Clinical Biochemistry and Nutrition, Год журнала: 2018, Номер 63(1), С. 33 - 35

Опубликована: Янв. 1, 2018

There have been many reports on the roles of intestinal flora and environment in health promotion disease prevention. Beneficial bacteria such as Bifidobacterium lactic acid-producing shown to improve environment, yield a good effect metabolism, immunity nerve response. In this review, addition these beneficial bacteria, we introduced Akkermansia muciniphila next-generation microbe. Several indicate that affects glucose lipid immunity, certain food ingredients polyphenols may increase abundance gut.

Язык: Английский

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Grifola frondosapolysaccharides ameliorate lipid metabolic disorders and gut microbiota dysbiosis in high-fat diet fed rats

Food & Function, Год журнала: 2019, Номер 10(5), С. 2560 - 2572

Опубликована: Янв. 1, 2019

G. frondosapolysaccharides have the potential to ameliorate lipid metabolic disorders in part through modulating gut microbiota and mRNA expression of genes involved hepatic cholesterol metabolism.

Язык: Английский

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Lipoteichoic acid from the cell wall of a heat killed Lactobacillus paracasei D3-5 ameliorates aging-related leaky gut, inflammation and improves physical and cognitive functions: from C. elegans to mice

GeroScience, Год журнала: 2019, Номер 42(1), С. 333 - 352

Опубликована: Дек. 8, 2019

Язык: Английский

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Nutritional Status and the Influence of the Vegan Diet on the Gut Microbiota and Human Health

Medicina, Год журнала: 2020, Номер 56(2), С. 88 - 88

Опубликована: Фев. 22, 2020

The human gut microbiota is considered a well-known complex ecosystem composed of distinct microbial populations, playing significant role in most aspects health and wellness. Several factors such as infant transitions, dietary habits, age, consumption probiotics prebiotics, use antibiotics, intestinal comorbidities, even metabolic diseases may continously alter diversity function. study vegan diet–microbiota interactions rapidly evolving field, since plenty research has been focused on the potential effects plant-based patterns microbiota. It reported that well-planned diets their associated components affect both bacterial composition pathways Certain benefits with medical disorders but also limitations (including nutritional deficiencies) have documented. Although diet be inadequate calorific value, it rich fiber, polyphenols, antioxidant vitamins. aim present was to provide an update existing knowledge status influence food health.

Язык: Английский

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Recognizing the Benefits of Pre-/Probiotics in Metabolic Syndrome and Type 2 Diabetes Mellitus Considering the Influence of Akkermansia muciniphila as a Key Gut Bacterium

Microorganisms, Год журнала: 2021, Номер 9(3), С. 618 - 618

Опубликована: Март 17, 2021

Metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM) are diseases that can be influenced by the structure of gut microbiota, whose improvement is often neglected in metabolic pathology. This review highlights following main aspects: relationship between probiotics/gut microbes with pathogenesis MetS, particular positive roles Akkermansia muciniphila supplementation onset interaction dietary polyphenols (prebiotics) microbiota. Therefore, an extensive in-depth analysis often-neglected correlation microbiota chronic was conducted, considering this topic continues to fascinate stimulate researchers through discovery novel strains their beneficial properties.

Язык: Английский

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Desulfovibrio Bacteria Are Associated With Parkinson’s Disease

Frontiers in Cellular and Infection Microbiology, Год журнала: 2021, Номер 11

Опубликована: Май 3, 2021

Parkinson’s disease (PD) is the most prevalent movement disorder known and predominantly affects elderly. It a progressive neurodegenerative wherein α-synuclein, neuronal protein, aggregates to form toxic structures in nerve cells. The cause of remains unknown. Intestinal dysfunction changes gut microbiota, common symptoms PD, are evidently linked pathogenesis PD. Although multitude studies have investigated microbial etiologies role progression unclear. Here, we show that Gram-negative sulfate-reducing bacteria genus Desulfovibrio may play potential development Conventional quantitative real-time PCR analysis feces from twenty PD patients healthy controls revealed all harbored their microbiota these were present at higher levels than controls. Additionally, concentration species correlated with severity produce hydrogen sulfide lipopolysaccharide, several strains synthesize magnetite, which likely induce oligomerization aggregation α-synuclein protein. substances originating take part These findings open new avenues for treatment identification people risk developing

Язык: Английский

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Genomic diversity and ecology of human-associated Akkermansia species in the gut microbiome revealed by extensive metagenomic assembly

Genome biology, Год журнала: 2021, Номер 22(1)

Опубликована: Июль 14, 2021

Abstract Background Akkermansia muciniphila is a human gut microbe with key role in the physiology of intestinal mucus layer and reported associations decreased body mass increased barrier function health. Despite its biomedical relevance, genomic diversity A. remains understudied that closely related species, except for glycaniphila , unexplored. Results We present large-scale population genomics analysis genus using 188 isolate genomes 2226 assembled from 18,600 metagenomes humans other animals. While we do not detect strains can be grouped into five distinct candidate including show remarkable whole-genome divergence despite surprisingly similar 16S rRNA gene sequences. These species are likely human-specific, as they detected mice non-human primates almost exclusively when kept captivity. In humans, display ecological co-exclusion, diversified functional capabilities, patterns host mass. Analysis CRISPR-Cas loci reveals new variants spacers targeting newly discovered putative bacteriophages. Remarkably, observe an relative abundance cognate predicted bacteriophages present, suggesting interactions. further exhibits subspecies-level genetic stratification associated differences such exo/lipopolysaccharide operon. Conclusions uncover large phylogenetic humans. This variability should considered ongoing experimental metagenomic efforts to characterize health-associated properties bacteria.

Язык: Английский

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Gut bacterial profiles in Parkinson's disease: A systematic review

CNS Neuroscience & Therapeutics, Год журнала: 2022, Номер 29(1), С. 140 - 157

Опубликована: Окт. 25, 2022

Abstract Introduction Recent advances have highlighted the relationships between gut dysbiosis and Parkinson's disease (PD). Microbiota transplantation from PD patients to mice can induce increased alpha‐synuclein‐mediated motor deficits. Human studies identified differences in microbiota of compared healthy controls. We undertook a systematic review evaluate available evidence for involvement bacteria etiology PD. Methods The PubMed databank, China National Knowledge Infrastructure Wanfang Data were searched inception until June 2021 identify human case–control that investigated quantified feces. evaluated resulting focusing on bacterial taxa different Results Twenty‐six found which 53 microbial families 98 genera exhibited with by more than two as Bifidobacterium , Alistipes Christensenella Enterococcus Oscillospira Bilophila Desulfovibrio Escherichia/Shigella Akkermansia while Prevotella Blautia Faecalibacterium Fusicatenibacter Haemophilus had three or reports being lower patients. More one report demonstrated Bacteroides Odoribacter Parabacteroides Butyricicoccus Butyrivibrio Clostridium Coprococcus Lachnospira Lactobacillus Megasphaera Phascolarctobacterium Roseburia Ruminococcus Streptococcus Klebsiella altered both directions. Conclusion Our shows microbiome may involve alterations short‐chain fatty acids (SCFAs)‐producing an increase putative pathobionts. SCFAs‐producing vary above below “optimal range,” causing imbalances. Considering are beneficial health, be associated medications, especially COMT inhibitors, high level aging.

Язык: Английский

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The role of Akkermansia muciniphila in inflammatory bowel disease: Current knowledge and perspectives

Frontiers in Immunology, Год журнала: 2023, Номер 13

Опубликована: Янв. 6, 2023

Inflammatory bowel diseases, including Crohn's disease and ulcerative colitis, is a chronic relapsing gastrointestinal inflammatory mediated by dysregulated immune responses to resident intestinal microbiota. Current conventional approaches aminosalicylates, corticosteroids, immunosuppressive agents, biological therapies are focused on reducing inflammation besides inducing maintaining remission, managing complications. However, these not curative associated with various limitations, such as drug resistance, low responsiveness adverse events. Recent accumulated evidence has revealed the involvement of mucin-degrading bacterium

Язык: Английский

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