Silibinin as a major component of milk thistle seed provides promising influences against diabetes and its complications: a systematic review

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер 397(10), С. 7531 - 7549

Опубликована: Май 27, 2024

Язык: Английский

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Caffeic acid and its derivative caffeic acid phenethyl ester as potential therapeutic compounds for cardiovascular diseases: A systematic review

Archiv der Pharmazie, Год журнала: 2024, Номер 357(10)

Опубликована: Июль 15, 2024

Abstract Cardiovascular diseases (CVDs) contribute to major public health issues. Some studies have found that caffeic acid (CA) and phenethyl ester (CAPE) may effectively prevent or treat CVDs. However, there is a need sum up our current understanding of the possible beneficial detrimental effects CA CAPE on CVDs related mechanisms. Therefore, this study aimed summarize data topic. A methodical search was carried out key databases, including Pubmed, Google Scholar, Scopus, Web Science, from beginning June 2024. Studies were then assessed for eligibility based inclusion exclusion criteria. Treatment with significantly positively affected cardiovascular in various aspects, atherosclerotic diseases, myocardial infarction, hypertension, cardiac arrhythmias, hypercoagulation state. Several mechanisms proposed mediate these effects, transcription factors signaling pathways associated antioxidant, cytostatic, anti‐inflammatory processes. several via multiple during prevention treatment promising only reported through vitro animal studies, which reinforces further evaluation human clinical investigations.

Язык: Английский

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Daidzin and its de‐glycosylated constituent daidzein as a potential therapeutic for cardiovascular diseases: A review from bench to bed

Phytotherapy Research, Год журнала: 2024, Номер 38(8), С. 3973 - 3985

Опубликована: Июнь 7, 2024

Continuing research is being conducted on novel preventive and therapeutic drugs for cardiovascular diseases (CVDs). Daidzein has shown potential beneficial effects regarding various CVDs risk factors. However, data in this regard are inconsistent, there an urge to accumulate. Therefore, we reviewed the of daidzein daidzin CVDs. We a search through Scopus, PubMed, Google Scholar, Web Science from inception up October 2023 find studies with primary intention assessing impacts disease vitro, animal, clinical settings. In vitro animal showed that effective terms reducing inflammation, oxidative stress, hyperlipidemia, myocardial infarction, thromboembolism, hypertension, aneurysms. only confirmed relatively small portion previous findings investigations, including anti-hyperlipidemic effects. conclusion, have reported most were unable exhibit same results. Hence, further required determine outcomes administering its derivatives extended period doses.

Язык: Английский

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How hesperidin and Hesperetin, as promising food Supplements, combat cardiovascular Diseases: A systematic review from bench to bed

Journal of Functional Foods, Год журнала: 2024, Номер 120, С. 106358 - 106358

Опубликована: Июль 20, 2024

Язык: Английский

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Overview of Ethnobotanical–Pharmacological Studies Carried Out on Medicinal Plants from the Serra da Estrela Natural Park: Focus on Their Antidiabetic Potential

Pharmaceutics, Год журнала: 2024, Номер 16(4), С. 454 - 454

Опубликована: Март 25, 2024

The Serra da Estrela Natural Park (NPSE) in Portugal stands out as a well-preserved region abundant medicinal plants, particularly known for their pharmaceutical applications diabetes prevention and treatment. This comprehensive review explores these plants’ botanical diversity, traditional uses, pharmacological applications, chemical composition. NPSE boast rich diversity with 138 plants across 55 families identified traditionally pharmacologically used against globally. Notably, the Asteraceae Lamiaceae are prevalent antidiabetic applications. In vitro studies have revealed significant inhibition of carbohydrate-metabolizing enzymes, certain plant co-products regulate genes involved carbohydrate metabolism insulin secretion. vivo trials demonstrated effects, including glycaemia regulation, secretion, antioxidant activity, lipid profile modulation. Medicinal exhibit various activities beyond antidiabetic, such antioxidant, anti-inflammatory, antibacterial, anti-cancer, more. Chemical analyses over fifty compounds like phenolic acids, flavonoids, terpenoids, polysaccharides responsible efficacy diabetes. These findings underscore potential candidates, urging further research to develop effective plant-based drugs, beverages, supplements.

Язык: Английский

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Investigation of Antioxidant, Antidiabetic, and Antiglycation Properties of Sonchus oleraceus and Lobularia maritima (L.) Desv. Extracts from Taza, Morocco

Food Chemistry Advances, Год журнала: 2025, Номер unknown, С. 100912 - 100912

Опубликована: Фев. 1, 2025

Язык: Английский

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Efficacy of Traditional Chinese Medicine combined with Conventional Western Medicine on Metabolic Syndrome: A Bayesian Network Meta-Analysis

Journal of Herbal Medicine, Год журнала: 2025, Номер unknown, С. 100998 - 100998

Опубликована: Фев. 1, 2025

Язык: Английский

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In Silico and In Vivo Investigation of the Anti-Hyperglycemic Effects of Caffeic Acid

ACS Omega, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Hyperglycemia, characterized by elevated blood glucose levels, is a major risk factor for diabetes mellitus and its complications. While conventional therapies are effective, they often associated with side effects high costs, necessitating alternative strategies. This study evaluates the potential of caffeic acid (CA), phenolic compound reported antihyperglycemic properties, using both in silico vivo approaches. Molecular docking simulations revealed that CA demonstrates strong binding affinity to protein tyrosine phosphatase 1B (PTP1B), critical enzyme metabolism, superior interaction profiles compared reference drug, ertiprotafib. In studies, Drosophila melanogaster model was used investigate under hyperglycemic conditions induced high-sugar diet. Treatment CA, particularly at concentration 500 μM, significantly reduced hemolymph levels improved several physiological behavioral parameters, including survival rates, body size, weight, larval movement. Furthermore, gene expression analysis demonstrated modulates key metabolic stress-related pathways, enhancing homeostasis reducing stress. These findings highlight dual utility methodologies elucidating CA. The results support development as cost-effective ethically viable therapeutic candidate implications management resource-limited settings.

Язык: Английский

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Optimization of ultrasound-assisted extraction of Ehretia asperula leaves with antioxidant and anti-diabetic activities and assessment of the process environmental impacts

Sustainable Chemistry and Pharmacy, Год журнала: 2025, Номер 45, С. 102039 - 102039

Опубликована: Май 8, 2025

Язык: Английский

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Dose‐Dependent Improvement of Caffeic Acid Against Acrylamide‐Induced Male Reproductive Dysfunction

Drug Development Research, Год журнала: 2025, Номер 86(4)

Опубликована: Май 22, 2025

ABSTRACT Dietary exposure to acrylamide is almost unavoidable and may result into long‐term consequences. It has been reported cause sexual dysfunction even infertility. This study aimed investigate the protective effects of caffeic acid against acrylamide‐induced reproductive in male rats. Group 1 served as control; group 2 received at a dose 40 mg/kg for 10 days. In groups, 3–6, was given 2, followed by therapy (10, 20, 30, mg/kg) 3 consecutive found that causes significant alteration serum concentrations FSH, testosterone, LH; decreased sperm motility viability. Acrylamide administration biochemical parameters including lipid peroxidation, reduced glutathione, antioxidant enzymes (SOD CAT) along with triglyceride, cholesterol, seminal fructose. Moreover, histological alterations promotes DNA damage evident COMET assay. After treatment, serological, biochemical, returned normal ranges. Based on our findings, it reasonable conclude acid, natural antioxidant, potential medication lessen any harmful gonads brought consumption.

Язык: Английский

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