β-Cyclodextrin metal-organic framework as a green carrier to improve the dissolution, bioavailability, and liver protective effect of luteolin DOI Creative Commons
Dan Yang, Min Zhao,

Yihe Huang

и другие.

International Journal of Pharmaceutics X, Год журнала: 2024, Номер 7, С. 100250 - 100250

Опубликована: Апрель 26, 2024

The incidence of acetaminophen-induced liver injury has increased, but effective prevention methods are limited. Although luteolin hepatoprotective activity, its low solubility and bioavailability limit applications. Cyclodextrin metal-organic frameworks (CD-MOFs) possess 3D-network structures large inner cavities, which make them excellent carriers poorly soluble drugs. In this study, we used CD-MOFs as to improve the dissolution assessed their antioxidant bioavailability, effects. Luteolin was loaded into β-CD-MOF, γ-CD-MOF, β-CD, γ-CD, characterized by powder X-ray diffractometry (PXRD) thermogravimetric analysis (TGA). Our results showed that luteolin-β-CD-MOF most stable. main driving forces were hydrogen bonds van der Waals forces, determined molecular simulation. loading capacity 14.67 wt%. Compared raw luteolin, exhibited a 4.50-fold increase in increased activity

Язык: Английский

Current advances in the synthesis of beta-cyclodextrin-based metal organic frameworks and their potential applications in the adsorption/removal of pollutants: A comprehensive review DOI
Parisa Ahmadi, Azam Ahmadi, Mahnaz Tabibiazar

и другие.

Carbohydrate Polymers, Год журнала: 2025, Номер 353, С. 123241 - 123241

Опубликована: Янв. 9, 2025

Язык: Английский

Процитировано

1
Dietary bile acids reduced ferroptosis, improved the flesh quality and intestinal health of Pacific white shrimp (Litopenaeus vannamei) fed the high plant protein-based diets DOI

Kangyuan Qu,

Junwei Zeng, Junming Deng

и другие.

Aquaculture, Год журнала: 2025, Номер unknown, С. 742562 - 742562

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
β-Cyclodextrin metal-organic framework as a green carrier to improve the dissolution, bioavailability, and liver protective effect of luteolin DOI Creative Commons
Dan Yang, Min Zhao,

Yihe Huang

и другие.

International Journal of Pharmaceutics X, Год журнала: 2024, Номер 7, С. 100250 - 100250

Опубликована: Апрель 26, 2024

The incidence of acetaminophen-induced liver injury has increased, but effective prevention methods are limited. Although luteolin hepatoprotective activity, its low solubility and bioavailability limit applications. Cyclodextrin metal-organic frameworks (CD-MOFs) possess 3D-network structures large inner cavities, which make them excellent carriers poorly soluble drugs. In this study, we used CD-MOFs as to improve the dissolution assessed their antioxidant bioavailability, effects. Luteolin was loaded into β-CD-MOF, γ-CD-MOF, β-CD, γ-CD, characterized by powder X-ray diffractometry (PXRD) thermogravimetric analysis (TGA). Our results showed that luteolin-β-CD-MOF most stable. main driving forces were hydrogen bonds van der Waals forces, determined molecular simulation. loading capacity 14.67 wt%. Compared raw luteolin, exhibited a 4.50-fold increase in increased activity

Язык: Английский

Процитировано

1