β-Cyclodextrin metal-organic framework as a green carrier to improve the dissolution, bioavailability, and liver protective effect of luteolin DOI Creative Commons
Dan Yang, Min Zhao,

Yihe Huang

et al.

International Journal of Pharmaceutics X, Journal Year: 2024, Volume and Issue: 7, P. 100250 - 100250

Published: April 26, 2024

The incidence of acetaminophen-induced liver injury has increased, but effective prevention methods are limited. Although luteolin hepatoprotective activity, its low solubility and bioavailability limit applications. Cyclodextrin metal-organic frameworks (CD-MOFs) possess 3D-network structures large inner cavities, which make them excellent carriers poorly soluble drugs. In this study, we used CD-MOFs as to improve the dissolution assessed their antioxidant bioavailability, effects. Luteolin was loaded into β-CD-MOF, γ-CD-MOF, β-CD, γ-CD, characterized by powder X-ray diffractometry (PXRD) thermogravimetric analysis (TGA). Our results showed that luteolin-β-CD-MOF most stable. main driving forces were hydrogen bonds van der Waals forces, determined molecular simulation. loading capacity 14.67 wt%. Compared raw luteolin, exhibited a 4.50-fold increase in increased activity

Language: Английский

Current advances in the synthesis of beta-cyclodextrin-based metal organic frameworks and their potential applications in the adsorption/removal of pollutants: A comprehensive review DOI
Parisa Ahmadi, Azam Ahmadi, Mahnaz Tabibiazar

et al.

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 353, P. 123241 - 123241

Published: Jan. 9, 2025

Language: Английский

Citations

1
Dietary bile acids reduced ferroptosis, improved the flesh quality and intestinal health of Pacific white shrimp (Litopenaeus vannamei) fed the high plant protein-based diets DOI

Kangyuan Qu,

Junwei Zeng, Junming Deng

et al.

Aquaculture, Journal Year: 2025, Volume and Issue: unknown, P. 742562 - 742562

Published: April 1, 2025

Language: Английский

Citations

0
β-Cyclodextrin metal-organic framework as a green carrier to improve the dissolution, bioavailability, and liver protective effect of luteolin DOI Creative Commons
Dan Yang, Min Zhao,

Yihe Huang

et al.

International Journal of Pharmaceutics X, Journal Year: 2024, Volume and Issue: 7, P. 100250 - 100250

Published: April 26, 2024

The incidence of acetaminophen-induced liver injury has increased, but effective prevention methods are limited. Although luteolin hepatoprotective activity, its low solubility and bioavailability limit applications. Cyclodextrin metal-organic frameworks (CD-MOFs) possess 3D-network structures large inner cavities, which make them excellent carriers poorly soluble drugs. In this study, we used CD-MOFs as to improve the dissolution assessed their antioxidant bioavailability, effects. Luteolin was loaded into β-CD-MOF, γ-CD-MOF, β-CD, γ-CD, characterized by powder X-ray diffractometry (PXRD) thermogravimetric analysis (TGA). Our results showed that luteolin-β-CD-MOF most stable. main driving forces were hydrogen bonds van der Waals forces, determined molecular simulation. loading capacity 14.67 wt%. Compared raw luteolin, exhibited a 4.50-fold increase in increased activity

Language: Английский

Citations

1