Immunomodulatory, Anti-Inflammatory, and Anti-Cancer Properties of Ginseng: A Pharmacological Update

Molecules, Год журнала: 2023, Номер 28(9), С. 3863 - 3863

Опубликована: Май 3, 2023

Ginseng, a medicinal plant of the genus Panax, boasts rich historical record usage that dates back to Paleolithic period. This botanical is extensively acknowledged and consumed in Eastern countries for its therapeutic properties, and, Western countries, it becoming increasingly popular as remedy fatigue asthenia. review provides an update on current research pertaining ginseng isolated compounds, namely, ginsenosides polysaccharides. The primary focus three crucial pharmacological activities, immunomodulation, anti-inflammatory, anti-cancer effects. encompasses studies both compounds various extracts obtained from root, leaves, berries.

Язык: Английский

---

Advances in the biosynthesis and metabolic engineering of rare ginsenosides

Applied Microbiology and Biotechnology, Год журнала: 2023, Номер 107(11), С. 3391 - 3404

Опубликована: Май 1, 2023

Язык: Английский

---

Ginsenoside Rh2 augmented anti-PD-L1 immunotherapy by reinvigorating CD8+ T cells via increasing intratumoral CXCL10

Pharmacological Research, Год журнала: 2023, Номер 198, С. 106988 - 106988

Опубликована: Ноя. 19, 2023

Profiting from the sustained clinical improvement and prolonged patient survival, immune checkpoint blockade of programmed cell death protein 1 (PD-1)/programmed death-ligand (PD-L1) axis has emerged as a revolutionary cancer therapy approach. However, anti-PD-1/PD-L1 antibodies only achieve response rate approximately 20%. Herein, we identified novel combination strategy that Chinese medicine ginseng-derived ginsenoside Rh2 (Rh2) markedly improved anti-cancer efficacy anti-PD-L1 antibody in mice bearing MC38 tumor. combined with (combo treatment) further triggered infiltration, proliferation activation CD8+ T cells tumor microenvironment (TME). Depletion by mouse CD8 blocking abolished effect combo treatment totally. Mechanistically, increased expression CXCL10 through activating TBK1-IRF3 signaling pathway, explaining infiltration cells. Employing anti- CXC chemokine receptor 3 (CXCR3) prevented treatment. Meanwhile, percentage M1-like macrophages raised ratio M1/M2 TME. By comparing among MC38, CT26 4T1 tumors, resident were considered prerequisite for effectiveness These findings demonstrated potentiated PD-L1 via promoting activation, which shed new light on to enhance immunotherapy using natural product Rh2.

Язык: Английский

---

An outlook on the versatility of plant saponins: A review

Fitoterapia, Год журнала: 2024, Номер 174, С. 105858 - 105858

Опубликована: Фев. 15, 2024

Язык: Английский

---

Mini-encyclopedia of mitochondria-relevant nutraceuticals protecting health in primary and secondary care—clinically relevant 3PM innovation

The EPMA Journal, Год журнала: 2024, Номер 15(2), С. 163 - 205

Опубликована: Апрель 18, 2024

Despite their subordination in humans, to a great extent, mitochondria maintain independent status but tightly cooperate with the "host" on protecting joint life quality and minimizing health risks. Under oxidative stress conditions, healthy promptly increase mitophagy level remove damaged "fellows" rejuvenating mitochondrial population sending fragments of mtDNA as SOS signals all systems human body. As long metabolic pathways are under systemic control well-concerted together, adaptive mechanisms become triggered increasing protection, activating antioxidant defense repair machinery. Contextually, attributes patho-/physiology instrumental for predictive medical approach cost-effective treatments tailored individualized patient profiles primary (to protect vulnerable individuals again health-to-disease transition) secondary affected disease progression) care. Nutraceuticals naturally occurring bioactive compounds demonstrating health-promoting, illness-preventing, other health-related benefits. Keeping mind health-promoting properties nutraceuticals along therapeutic potential safety profile, there is permanently growing demand application mitochondria-relevant nutraceuticals. Application beneficial only if meeting needs at individual level. Therefore, risk assessment creation pivotal importance followed by adapted nutraceutical sets needs. Based scientific evidence available nutraceuticals, this article presents examples frequent which require protective measures targeted holistic following advanced concepts predictive, preventive, personalized medicine (PPPM/3PM)

Язык: Английский

---

Notoginsenoside Fc, a novel renoprotective agent, ameliorates glomerular endothelial cells pyroptosis and mitochondrial dysfunction in diabetic nephropathy through regulating HMGCS2 pathway

Phytomedicine, Год журнала: 2024, Номер 126, С. 155445 - 155445

Опубликована: Фев. 10, 2024

Язык: Английский

---

Modulating butyric acid-producing bacterial community abundance and structure in the intestine of immunocompromised mice with neutral polysaccharides extracted from Codonopsis pilosula

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 278, С. 134959 - 134959

Опубликована: Авг. 22, 2024

Язык: Английский

---

Geometric-aware deep learning enables discovery of bifunctional ligand-based liposomes for tumor targeting therapy

Nano Today, Год журнала: 2025, Номер 61, С. 102668 - 102668

Опубликована: Фев. 13, 2025

Язык: Английский

---

Bidirectional effects and mechanisms of traditional Chinese medicine

Journal of Ethnopharmacology, Год журнала: 2022, Номер 298, С. 115578 - 115578

Опубликована: Июль 31, 2022

Язык: Английский

---

Ginsenoside Rh2: A shining and potential natural product in the treatment of human nonmalignant and malignant diseases in the near future

Phytomedicine, Год журнала: 2023, Номер 118, С. 154938 - 154938

Опубликована: Июнь 20, 2023

Язык: Английский

---