Phytotherapy Research,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 1, 2025
ABSTRACT
Obesity,
along
with
its
associated
health
risks
such
as
hypertension,
hyperlipidemia,
Type
2
diabetes,
stroke,
metabolic
syndrome,
asthma,
and
cancer,
constitutes
a
significant
global
burden,
contributing
substantially
to
morbidity
mortality.
Cytokines,
group
of
secreted
signaling
proteins,
are
crucial
in
initiating,
maintaining,
resolving
immune
responses.
Although
cytokines
have
unique
advantages
regulating
functions,
their
therapeutic
application
for
obesity
remains
limited
clinical
practice.
Natural
compounds,
known
structural
diversity
low
toxicity,
become
valuable
resource
drug
development.
Many
natural
compounds
shown
anti‐obesity
effects.
This
review
comprehensively
examines
the
mechanisms
underlying
obesity,
specific
focus
on
roles
cytokines,
inflammatory
adipokines,
growth
factors.
Additionally,
it
highlights
regulatory
interactions
between
gut
microbiota
obesity.
The
critically
analyzes
current
pharmacological
interventions
summarizes
advanced
methodologies
identifying
potential
compounds.
Finally,
identifies
promising
that
modulate
cytokine
activity
prevent
or
treat
assesses
complementary
alternative
therapies.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(9), P. 3863 - 3863
Published: May 3, 2023
Ginseng,
a
medicinal
plant
of
the
genus
Panax,
boasts
rich
historical
record
usage
that
dates
back
to
Paleolithic
period.
This
botanical
is
extensively
acknowledged
and
consumed
in
Eastern
countries
for
its
therapeutic
properties,
and,
Western
countries,
it
becoming
increasingly
popular
as
remedy
fatigue
asthenia.
review
provides
an
update
on
current
research
pertaining
ginseng
isolated
compounds,
namely,
ginsenosides
polysaccharides.
The
primary
focus
three
crucial
pharmacological
activities,
immunomodulation,
anti-inflammatory,
anti-cancer
effects.
encompasses
studies
both
compounds
various
extracts
obtained
from
root,
leaves,
berries.
Pharmacological Research,
Journal Year:
2023,
Volume and Issue:
198, P. 106988 - 106988
Published: Nov. 19, 2023
Profiting
from
the
sustained
clinical
improvement
and
prolonged
patient
survival,
immune
checkpoint
blockade
of
programmed
cell
death
protein
1
(PD-1)/programmed
death-ligand
(PD-L1)
axis
has
emerged
as
a
revolutionary
cancer
therapy
approach.
However,
anti-PD-1/PD-L1
antibodies
only
achieve
response
rate
approximately
20%.
Herein,
we
identified
novel
combination
strategy
that
Chinese
medicine
ginseng-derived
ginsenoside
Rh2
(Rh2)
markedly
improved
anti-cancer
efficacy
anti-PD-L1
antibody
in
mice
bearing
MC38
tumor.
combined
with
(combo
treatment)
further
triggered
infiltration,
proliferation
activation
CD8+
T
cells
tumor
microenvironment
(TME).
Depletion
by
mouse
CD8
blocking
abolished
effect
combo
treatment
totally.
Mechanistically,
increased
expression
CXCL10
through
activating
TBK1-IRF3
signaling
pathway,
explaining
infiltration
cells.
Employing
anti-
CXC
chemokine
receptor
3
(CXCR3)
prevented
treatment.
Meanwhile,
percentage
M1-like
macrophages
raised
ratio
M1/M2
TME.
By
comparing
among
MC38,
CT26
4T1
tumors,
resident
were
considered
prerequisite
for
effectiveness
These
findings
demonstrated
potentiated
PD-L1
via
promoting
activation,
which
shed
new
light
on
to
enhance
immunotherapy
using
natural
product
Rh2.
The EPMA Journal,
Journal Year:
2024,
Volume and Issue:
15(2), P. 163 - 205
Published: April 18, 2024
Despite
their
subordination
in
humans,
to
a
great
extent,
mitochondria
maintain
independent
status
but
tightly
cooperate
with
the
"host"
on
protecting
joint
life
quality
and
minimizing
health
risks.
Under
oxidative
stress
conditions,
healthy
promptly
increase
mitophagy
level
remove
damaged
"fellows"
rejuvenating
mitochondrial
population
sending
fragments
of
mtDNA
as
SOS
signals
all
systems
human
body.
As
long
metabolic
pathways
are
under
systemic
control
well-concerted
together,
adaptive
mechanisms
become
triggered
increasing
protection,
activating
antioxidant
defense
repair
machinery.
Contextually,
attributes
patho-/physiology
instrumental
for
predictive
medical
approach
cost-effective
treatments
tailored
individualized
patient
profiles
primary
(to
protect
vulnerable
individuals
again
health-to-disease
transition)
secondary
affected
disease
progression)
care.
Nutraceuticals
naturally
occurring
bioactive
compounds
demonstrating
health-promoting,
illness-preventing,
other
health-related
benefits.
Keeping
mind
health-promoting
properties
nutraceuticals
along
therapeutic
potential
safety
profile,
there
is
permanently
growing
demand
application
mitochondria-relevant
nutraceuticals.
Application
beneficial
only
if
meeting
needs
at
individual
level.
Therefore,
risk
assessment
creation
pivotal
importance
followed
by
adapted
nutraceutical
sets
needs.
Based
scientific
evidence
available
nutraceuticals,
this
article
presents
examples
frequent
which
require
protective
measures
targeted
holistic
following
advanced
concepts
predictive,
preventive,
personalized
medicine
(PPPM/3PM)
Research Journal of Pharmacy and Technology,
Journal Year:
2022,
Volume and Issue:
unknown, P. 4594 - 4600
Published: Oct. 21, 2022
Background;
panax
ginseng
is
one
of
the
best
ayurvedic
plant
used
for
treatment
several
types
disease
such
as
diabetes,
improve
libido
and
hair-lose
antioxidant
also
decrease
side
effect
toxicity
chemotherapy
toxic
substances
studies
show
that
it
may
have
an
anticancer
effect.
Aim:
to
find
out
cardiotoxicity
occur
a
result
chemotherapeutic
medication
doxorubicin
on
cellular
biomarker
cancer
suppressor
substance
evaluation
possible
ginseng.
Methods:
forty
rate
module
has
been
enrolled
in
this
study,
divided
into
four
groups
ten
rats
each
groups,
first
group
receive
purified
water,
second
Panax
orally
100mg/kg
dose,
third
with
whereas
last
high
dose
only,
blood
sample
collected
organs
heart
extracted,
serum
level
modulators
evaluated.
Results:
significantly
reduce
by
its
mechanism,
reduced
cardiac
troponin
(cTnI)
However,
reduction
BNP
levels
insignificantly
compared
P=0.06.
LPO
MDA
raised
potential
GSH
P<0.05.
inflammatory
(TNF-α)
apoptotic
(caspase-3)
biomarkers
when
group.
ginsing
increase
caspase
addition,
MDA,
LPO,
TNF-α,
caspase-3
were
increased
control
Conclusions:
our
research,
cardioprotective
supresses
oxidative
stress
other
cardiotoxic
parameters
,
However
itself
through
medullated
apoptosis
casepace
3
significantly.
