NRF2-mediated regulation of lipid pathways in viral infection
Molecular Aspects of Medicine,
Год журнала:
2024,
Номер
97, С. 101279 - 101279
Опубликована: Май 20, 2024
Язык: Английский
Korean Black Ginseng Extract Alleviates Alzheimer’s Disease-Related Cognitive Impairment by Activating the Nrf2/HO-1 Pathway and Suppressing the p38 MAPK/NF-κB/STAT3 Pathways and NLRP3 Inflammasome via TLR2 and TLR4 Modulation
Journal of Ginseng Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Anti-Colorectal Cancer Activity of Panax and Its Active Components, Ginsenosides: A Review
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(6), С. 2593 - 2593
Опубликована: Март 13, 2025
Colorectal
cancer
(CRC)
poses
a
significant
health
burden
worldwide
and
necessitates
novel
treatment
approaches
with
fewer
side
effects
than
conventional
chemotherapy.
Many
natural
compounds
have
been
tested
as
possible
treatments.
Plants
in
the
genus
Panax
widely
studied
due
to
their
therapeutic
potential
for
various
diseases
such
inflammatory
disorders
cancers.
Extracts
from
plants
of
activate
upstream
signals,
including
those
related
autophagy
generation
reactive
oxygen
species,
induce
intrinsic
apoptosis
CRC
cells.
The
root
extract
notoginseng
(P.
notoginseng)
regulated
gut
microbiota
enhance
T-cell-induced
immune
response
against
CRC.
Protopanaxadiol
(PPD)-type
ginsenosides,
especially
Rh2,
Rg3,
Rb1,
Rb2,
significantly
reduced
proliferation
cells
tumor
size
xenograft
mouse
model,
well
targeting
programmed
death
(PD)-1
block
checkpoint
Moreover,
modified
nanocarriers
ginsenosides
upregulated
drug
efficacy,
showing
that
can
also
be
utilized
carriers.
An
increasing
body
studies
has
demonstrated
curing
Ginsenosides
are
promising
active
Panax,
which
support
activity
therapies.
Язык: Английский
Protective effect of ginseng berry saponin conversion products on skin photodamage caused by UVB in vitro and in vivo
Hongyan Tan,
Honghong Ren,
Jiayi Chai
и другие.
Food Research International,
Год журнала:
2024,
Номер
198, С. 115379 - 115379
Опубликована: Ноя. 20, 2024
Язык: Английский
Antiviral potential of ginseng: Targeting human pathogenic viruses with compounds derived from ginseng
Journal of Ginseng Research,
Год журнала:
2024,
Номер
49(2), С. 105 - 117
Опубликована: Дек. 10, 2024
The
COVID-19
pandemic
has
highlighted
the
critical
need
for
effective
antiviral
therapies,
as
viral
infections
remain
a
leading
cause
of
mortality
worldwide.
Natural
compounds,
especially
those
derived
from
plants,
have
been
recognized
their
therapeutic
properties.
Ginseng,
in
particular,
attracted
considerable
attention
its
potential
effects.
This
review
examines
compounds
ginseng
that
act
against
various
human
pathogenic
viruses.
We
systematically
summarize
activities
targeting
range
viruses,
including
rhinovirus
(HRV),
influenza
virus,
immunodeficiency
virus
(HIV),
hepatitis
viruses
A,
B,
and
C
(HAV,
HBV,
HCV),
herpes
simplex
(HSV),
enterovirus
71
(EV71),
coxsackievirus,
norovirus,
SARS-CoV-2,
responsible
COVID-19.
covers
Panax
ginseng,
P.
notoginseng,
quinquefolius,
discussing
mechanisms
action
potential.
analysis
incorporates
literature
February
2002
through
August
2024,
providing
comprehensive
overview
existing
evidence
on
properties
ginseng.
aims
to
underscore
scientific
basis
developing
an
agent
or
nutraceutical.
Язык: Английский
JAG1 mediates apoptosis in herpes simplex keratitis by suppressing autophagy via ROS/JAG1/NOTCH1/pULK1 signaling pathway
Cell Biology and Toxicology,
Год журнала:
2024,
Номер
41(1)
Опубликована: Дек. 20, 2024
Herpes
simplex
keratitis
(HSK),
an
ocular
disease
resulted
from
herpes
virus
type
1
(HSV-1)
infection,
leads
to
the
majority
of
infectious
corneal
blindness
worldwide.
The
apoptosis
epithelial
cells
(CECs)
HSV-1
disrupts
barrier
and
exacerbates
infection;
however,
there
is
no
definitive
cure
for
HSK.
Jagged1
(JAG1),
one
primary
functional
ligands
NOTCH
receptors,
plays
a
crucial
role
in
regulating
autophagy;
its
HSK
unclear.
Our
transcriptome
analysis
showed
JAG1
was
significantly
upregulated
HSV-1-infected
human
CECs.
We
aimed
explore
JAG1's
CECs
mice.
infection
induced
reactive
oxygen
species
(ROS)
generation
also
activated
JAG1/NOTCH1
signaling
pathway.
ROS
scavenger
N-acetylcysteine
mitigated
these
effects.
Additionally,
inhibiting
pathway
with
short
hairpin
RNA
against
or
NOTCH1
inhibitor
(N-[N-{3,5-difuorophenacetyl}-1-alanyl]-S-phenylglycine
t-butyl
ester
[DAPT])
alleviated
HSV-1-induced
CEC
apoptosis.
Transmission
electron
microscopy
western
blotting
revealed
that
suppressed
ULK1-mediated
autophagy
CECs,
while
DAPT
treatment
enhanced
by
suppressing
ULK1
phosphorylation.
activation
rapamycin
markedly
reduced
levels
revealing
synergistic
effect
between
increased
levels,
ultimately
leading
Thus,
induces
through
ROS/JAG1/NOTCH1/pULK1
vitro
vivo,
providing
potential
therapeutic
targets
Язык: Английский