International Journal of Environmental Research and Public Health,
Год журнала:
2023,
Номер
20(4), С. 3617 - 3617
Опубликована: Фев. 17, 2023
Microplastics
in
freshwater
environments
pose
a
serious
threat
to
living
beings.
Polyethylene
microplastics
(PE-MP)
are
the
type
most
used
around
world
as
microbeads
personal
care
products,
and
they
have
been
found
aquatic
organisms.
The
behavior
toxicity
of
fluorescent
PE-MP
spheres
with
an
average
diameter
58.9
μm
were
studied
adult,
juvenile
embryo
zebrafish
(Danio
rerio).
adults
for
genotoxicity,
cytotoxicity,
histology
biochemical
markers.
Juveniles
underwent
follow-up
gastrointestinal
(GI)
tract
histologic
observations,
embryos
embryotoxicity
FET-test.
In
adults,
micronucleus
test
comet
assays
neither
genotoxicity
after
acute
exposure
96
h
at
concentrations
0.0,
12.5,
50
100
mg.L−1,
nor
cytotoxicity
through
nuclear
abnormalities
test.
Acetylcholinesterase
(AChE),
Glutathione-S-Transferase
(GST)
Lactate
Dehydrogenase
(LDH)
activities
measured
exposed
h.
AChE
GST
significantly
changed,
while
no
changes
occurred
LDH.
conclusion,
these
did
not
cause
toxic
effects
because
there
was
internalization.
observed
may
be
associated
GI
microbiological
dysbiosis,
previously
reported.
intestine
juveniles
remained
present
12–15
days
on
post-exposure
clearance
study,
showing
slow
depuration.
histological
analysis,
internalization
microbeads,
complete
cross
chorion
barrier,
embryotoxic
exposures
6.25,
50.0
or
100.0
mg.L−1
Environmental Science & Technology,
Год журнала:
2023,
Номер
57(38), С. 14127 - 14137
Опубликована: Сен. 8, 2023
In
this
study,
we
investigated
the
mechanism
underlying
perturbation
of
hepatic
lipid
metabolism
in
response
to
micro/nanoplastic
(MP/NP)
exposure
at
environmentally
relevant
concentrations.
Polystyrene
(PS)
MPs/NPs
with
different
sizes
(0.1,
0.5,
and
5.0
μm)
were
studied
for
their
effects
on
homeostasis
function
Nile
tilapia
(Oreochromis
niloticus)
liver.
Results
showed
that
PS
readily
internalized
accumulated
various
internal
organs/tissues,
especially
fish
liver
muscle.
Smaller-sized
NPs
caused
more
severe
toxicity
than
larger
MPs,
including
steatosis,
inflammatory
response,
disturbed
function.
Mechanistically,
a
particle
size
100
nm
perturbed
protein
endoplasmic
reticulum
(ER)
by
inhibiting
expression
chaperone
proteins
genes
involved
ER-associated
degradation.
This
led
activation
PERK-eIF2α
pathway,
which
dysfunction
metabolism.
Induction
oxidative
stress
Nrf2/Keap1
pathway
also
NP-induced
accumulation.
These
findings
highlight
potential
adverse
environmental
aquatic
organisms,
raising
concerns
about
ecotoxicity
food
safety.