Toxics,
Год журнала:
2023,
Номер
11(2), С. 181 - 181
Опубликована: Фев. 16, 2023
Mercury
(Hg)
is
a
dangerous
and
persistent
trace
element.
Its
organic
highly
toxic
form,
methylmercury
(MeHg),
easily
crosses
biological
membranes
accumulates
in
biota.
Nevertheless,
understanding
the
mechanisms
of
dietary
MeHg
toxicity
fish
remains
challenge.
A
time-course
experiment
was
conducted
with
juvenile
white
seabreams,
Diplodus
sargus
(Linnaeus,
1758),
exposed
to
realistic
levels
feed
(8.7
μg
g-1,
dry
weight),
comprising
exposure
(E;
7
14
days)
post-exposure
(PE;
28
periods.
Total
Hg
increased
time
gills
liver
during
E
decreased
significantly
PE
(though
control
were
reached
only
for
gills),
exhibiting
higher
(2.7
times)
than
gills.
Nuclear
magnetic
resonance
(NMR)-based
metabolomics
revealed
multiple
often
differential
metabolic
changes
between
organs.
Gills
exhibited
protein
catabolism,
disturbances
cholinergic
neurotransmission,
osmoregulation
lipid
energy
metabolism.
However,
provoked
altered
metabolism
amino
acids,
likely
activation
defensive
strategies.
allowed
partial
recovery
both
organs,
even
if
occurrence
oxidative
stress
Overall,
these
findings
support
organ-specific
responses
according
their
sensitivity
exposure,
pointing
out
that
indications
obtained
biomonitoring
studies
may
depend
also
on
selected
organ.
Environmental Science & Technology,
Год журнала:
2023,
Номер
57(38), С. 14127 - 14137
Опубликована: Сен. 8, 2023
In
this
study,
we
investigated
the
mechanism
underlying
perturbation
of
hepatic
lipid
metabolism
in
response
to
micro/nanoplastic
(MP/NP)
exposure
at
environmentally
relevant
concentrations.
Polystyrene
(PS)
MPs/NPs
with
different
sizes
(0.1,
0.5,
and
5.0
μm)
were
studied
for
their
effects
on
homeostasis
function
Nile
tilapia
(Oreochromis
niloticus)
liver.
Results
showed
that
PS
readily
internalized
accumulated
various
internal
organs/tissues,
especially
fish
liver
muscle.
Smaller-sized
NPs
caused
more
severe
toxicity
than
larger
MPs,
including
steatosis,
inflammatory
response,
disturbed
function.
Mechanistically,
a
particle
size
100
nm
perturbed
protein
endoplasmic
reticulum
(ER)
by
inhibiting
expression
chaperone
proteins
genes
involved
ER-associated
degradation.
This
led
activation
PERK-eIF2α
pathway,
which
dysfunction
metabolism.
Induction
oxidative
stress
Nrf2/Keap1
pathway
also
NP-induced
accumulation.
These
findings
highlight
potential
adverse
environmental
aquatic
organisms,
raising
concerns
about
ecotoxicity
food
safety.
Animals,
Год журнала:
2022,
Номер
13(1), С. 147 - 147
Опубликована: Дек. 30, 2022
The
present
review
provides
detailed
information
on
the
adverse
effects
of
MPs
wild
marine
organisms,
including
tissue
damage,
fish
condition,
oxidative
stress,
immune
toxicity,
and
genotoxicity.
A
bibliometric
analysis
was
carried
out
CiteSpace
(version
6.1.R3)
(Drexel
University,
Philadelphia,
PA,
USA)
to
verify
how
many
papers
studied
species.
results
showed
a
total
395
articles,
but
only
22
really
presented
data
or
impacts
biota,
these,
12
articles
highlighted
negative
effects.
This
shows
that
observed
in
organisms
were
less
severe
milder
than
those
found
experimental
conditions.
knowledge
caused
by
direct
ingestion
microplastics
animals
is
still
limited;
more
efforts
are
necessary
fully
understand
role
ecosystem,
human
health.
Heliyon,
Год журнала:
2023,
Номер
9(1), С. e13070 - e13070
Опубликована: Янв. 1, 2023
Pollution-induced
neurotoxicity
is
of
high
concern.
This
pilot
study
investigated
the
potential
relationship
between
presence
microplastics
(MPs)
in
brain
180
wild
fish
(Dicentrarchus
labrax,
Platichthys
flesus,
Mugil
cephalus)
from
a
contaminated
estuary
and
activity
acetylcholinesterase
(AChE)
enzyme.
MPs
were
found
9
samples
(5%
total),
all
them
D.
labrax
collected
summer,
which
represents
45%
this
species
that
season
(20).
Seventeen
recovered
samples,
with
sizes
ranging
8
to
96
μm.
Polyacrylamide,
polyacrylic
acid
one
biopolymer
(zein)
identified
by
Micro-Raman
spectroscopy.
Fish
showed
lower
(p
≤
0.05)
AChE
than
those
where
not
found.
These
findings
point
contribution
induced
long-term
exposure
pollution,
stressing
need
further
studies
on
topic
increase
'One
Health'
protection.
In
recent
years,
micro-
and
nanoplastics
(MNPs)
have
represented
an
emerging
threat
for
the
aquatic
environment
due
to
their
persistence
widespread
distribution.
Indeed,
small
size
increased
surface
area
lead
a
high
biological
reactivity,
which
can
be
crucial
health
status
of
biota.
To
date,
several
studies
investigated
lethal
sublethal
endpoints
MNPs,
while
one
main
challenges
is
understand
mechanisms
toxicity
in
comprehensive
manner.
With
this
aim,
field
ecotoxicology
now
benefit
from
-omics
approaches.
This
review
focuses
on
advances
related
use
transcriptomics,
proteomics,
metabolomics
deeply
investigate
molecular
biochemical
responses
organisms,
both
fishes
invertebrates,
pristine
polystyrene
(PS)
MNPs.
The
literature
reviewed
revealed
that
transcriptomics
are
most
frequently
used
-omic
Overall,
taken
into
consideration
shed
light
events
triggered
by
PS
MNPs
at
cellular
levels,
identifying
as
pathways
involved
oxidative
stress,
energy
metabolism,
immune
response,
nervous
system.
Future
should
therefore
focus
integration
multi-omics
approaches
more
understanding
toxicity.
