Differential Cell Metabolic Pathways in Gills and Liver of Fish (White Seabream Diplodus sargus) Coping with Dietary Methylmercury Exposure DOI Creative Commons
Giuseppe De Marco,

Barbara Billè,

Fátima Brandão

и другие.

Toxics, Год журнала: 2023, Номер 11(2), С. 181 - 181

Опубликована: Фев. 16, 2023

Mercury (Hg) is a dangerous and persistent trace element. Its organic highly toxic form, methylmercury (MeHg), easily crosses biological membranes accumulates in biota. Nevertheless, understanding the mechanisms of dietary MeHg toxicity fish remains challenge. A time-course experiment was conducted with juvenile white seabreams, Diplodus sargus (Linnaeus, 1758), exposed to realistic levels feed (8.7 μg g-1, dry weight), comprising exposure (E; 7 14 days) post-exposure (PE; 28 periods. Total Hg increased time gills liver during E decreased significantly PE (though control were reached only for gills), exhibiting higher (2.7 times) than gills. Nuclear magnetic resonance (NMR)-based metabolomics revealed multiple often differential metabolic changes between organs. Gills exhibited protein catabolism, disturbances cholinergic neurotransmission, osmoregulation lipid energy metabolism. However, provoked altered metabolism amino acids, likely activation defensive strategies. allowed partial recovery both organs, even if occurrence oxidative stress Overall, these findings support organ-specific responses according their sensitivity exposure, pointing out that indications obtained biomonitoring studies may depend also on selected organ.

Язык: Английский

Food chain microplastics contamination and impact on human health: a review DOI

Chukwuebuka Gabriel Eze,

Chidiebele Nwankwo, Satarupa Dey

и другие.

Environmental Chemistry Letters, Год журнала: 2024, Номер 22(4), С. 1889 - 1927

Опубликована: Апрель 9, 2024

Язык: Английский

Процитировано

48

Nanoplastic Exposure at Environmental Concentrations Disrupts Hepatic Lipid Metabolism through Oxidative Stress Induction and Endoplasmic Reticulum Homeostasis Perturbation DOI
Weiyu Wang,

Xuan Mao,

Rui Zhang

и другие.

Environmental Science & Technology, Год журнала: 2023, Номер 57(38), С. 14127 - 14137

Опубликована: Сен. 8, 2023

In this study, we investigated the mechanism underlying perturbation of hepatic lipid metabolism in response to micro/nanoplastic (MP/NP) exposure at environmentally relevant concentrations. Polystyrene (PS) MPs/NPs with different sizes (0.1, 0.5, and 5.0 μm) were studied for their effects on homeostasis function Nile tilapia (Oreochromis niloticus) liver. Results showed that PS readily internalized accumulated various internal organs/tissues, especially fish liver muscle. Smaller-sized NPs caused more severe toxicity than larger MPs, including steatosis, inflammatory response, disturbed function. Mechanistically, a particle size 100 nm perturbed protein endoplasmic reticulum (ER) by inhibiting expression chaperone proteins genes involved ER-associated degradation. This led activation PERK-eIF2α pathway, which dysfunction metabolism. Induction oxidative stress Nrf2/Keap1 pathway also NP-induced accumulation. These findings highlight potential adverse environmental aquatic organisms, raising concerns about ecotoxicity food safety.

Язык: Английский

Процитировано

47

Hazards of microplastics exposure to liver function in fishes: A systematic review and meta-analysis DOI
Yu Sun, Qingfang Deng, Qiurong Zhang

и другие.

Marine Environmental Research, Год журнала: 2024, Номер 196, С. 106423 - 106423

Опубликована: Фев. 27, 2024

Язык: Английский

Процитировано

20

Adverse effects of polystyrene microplastics in the freshwater commercial fish, grass carp (Ctenopharyngodon idella): Emphasis on physiological response and intestinal microbiome DOI
Yaotong Hao,

Yanfeng Sun,

Mo Li

и другие.

The Science of The Total Environment, Год журнала: 2022, Номер 856, С. 159270 - 159270

Опубликована: Окт. 6, 2022

Язык: Английский

Процитировано

51

Environmental microplastics (EMPs) exposure alter the differentiation potential of mesenchymal stromal cells DOI

Hana Najahi,

Nicola Alessio, Tiziana Squillaro

и другие.

Environmental Research, Год журнала: 2022, Номер 214, С. 114088 - 114088

Опубликована: Авг. 13, 2022

Язык: Английский

Процитировано

45

Is Wild Marine Biota Affected by Microplastics? DOI Creative Commons
Nunziatina Porcino, Teresa Bottari, Monique Mancuso

и другие.

Animals, Год журнала: 2022, Номер 13(1), С. 147 - 147

Опубликована: Дек. 30, 2022

The present review provides detailed information on the adverse effects of MPs wild marine organisms, including tissue damage, fish condition, oxidative stress, immune toxicity, and genotoxicity. A bibliometric analysis was carried out CiteSpace (version 6.1.R3) (Drexel University, Philadelphia, PA, USA) to verify how many papers studied species. results showed a total 395 articles, but only 22 really presented data or impacts biota, these, 12 articles highlighted negative effects. This shows that observed in organisms were less severe milder than those found experimental conditions. knowledge caused by direct ingestion microplastics animals is still limited; more efforts are necessary fully understand role ecosystem, human health.

Язык: Английский

Процитировано

43

Polystyrene microplastics-induced macrophage extracellular traps contributes to liver fibrotic injury by activating ROS/TGF-β/Smad2/3 signaling axis DOI
Shengchen Wang,

Lu Chen,

Xu Shi

и другие.

Environmental Pollution, Год журнала: 2023, Номер 324, С. 121388 - 121388

Опубликована: Март 3, 2023

Язык: Английский

Процитировано

37

Are microplastics contributing to pollution-induced neurotoxicity? A pilot study with wild fish in a real scenario DOI Creative Commons
Luís Gabriel A. Barboza, Xosé Luís Otero,

Ezequiel V. Fernández

и другие.

Heliyon, Год журнала: 2023, Номер 9(1), С. e13070 - e13070

Опубликована: Янв. 1, 2023

Pollution-induced neurotoxicity is of high concern. This pilot study investigated the potential relationship between presence microplastics (MPs) in brain 180 wild fish (Dicentrarchus labrax, Platichthys flesus, Mugil cephalus) from a contaminated estuary and activity acetylcholinesterase (AChE) enzyme. MPs were found 9 samples (5% total), all them D. labrax collected summer, which represents 45% this species that season (20). Seventeen recovered samples, with sizes ranging 8 to 96 μm. Polyacrylamide, polyacrylic acid one biopolymer (zein) identified by Micro-Raman spectroscopy. Fish showed lower (p ≤ 0.05) AChE than those where not found. These findings point contribution induced long-term exposure pollution, stressing need further studies on topic increase 'One Health' protection.

Язык: Английский

Процитировано

31

Microplastic pollution destabilized the osmoregulatory metabolism but did not affect intestinal microbial biodiversity of earthworms in soil DOI Creative Commons
Ronggui Tang,

Minshen Ying,

Yongming Luo

и другие.

Environmental Pollution, Год журнала: 2023, Номер 320, С. 121020 - 121020

Опубликована: Янв. 9, 2023

Язык: Английский

Процитировано

26

Polystyrene Micro- and Nanoplastics (PS MNPs): A Review of Recent Advances in the Use of -Omics in PS MNP Toxicity Studies on Aquatic Organisms DOI Creative Commons
Maria Concetta Eliso,

Barbara Billè,

Tiziana Cappello

и другие.

Fishes, Год журнала: 2024, Номер 9(3), С. 98 - 98

Опубликована: Март 5, 2024

In recent years, micro- and nanoplastics (MNPs) have represented an emerging threat for the aquatic environment due to their persistence widespread distribution. Indeed, small size increased surface area lead a high biological reactivity, which can be crucial health status of biota. To date, several studies investigated lethal sublethal endpoints MNPs, while one main challenges is understand mechanisms toxicity in comprehensive manner. With this aim, field ecotoxicology now benefit from -omics approaches. This review focuses on advances related use transcriptomics, proteomics, metabolomics deeply investigate molecular biochemical responses organisms, both fishes invertebrates, pristine polystyrene (PS) MNPs. The literature reviewed revealed that transcriptomics are most frequently used -omic Overall, taken into consideration shed light events triggered by PS MNPs at cellular levels, identifying as pathways involved oxidative stress, energy metabolism, immune response, nervous system. Future should therefore focus integration multi-omics approaches more understanding toxicity.

Язык: Английский

Процитировано

13