The Science of The Total Environment, Год журнала: 2023, Номер 912, С. 169555 - 169555
Опубликована: Дек. 28, 2023
Язык: Английский
The Science of The Total Environment, Год журнала: 2023, Номер 912, С. 169555 - 169555
Опубликована: Дек. 28, 2023
Язык: Английский
Journal of Hazardous Materials, Год журнала: 2023, Номер 465, С. 133175 - 133175
Опубликована: Дек. 7, 2023
Язык: Английский
Процитировано
24The Science of The Total Environment, Год журнала: 2022, Номер 853, С. 158600 - 158600
Опубликована: Сен. 8, 2022
Язык: Английский
Процитировано
31Environment International, Год журнала: 2023, Номер 181, С. 108248 - 108248
Опубликована: Окт. 12, 2023
More than 7 million early deaths/year are attributable to air pollution. Current health concerns especially focused on pollution-derived particulate matter (PM). Although oxidative stress-induced airway inflammation is one of the main adverse outcome pathways triggered by PM, persistence both these underlying mechanisms, even after exposure cessation, remained poorly studied. In this study, A/JOlaHsd mice were also exposed acutely (24 h) or sub-chronically (4 weeks), with without a recovery period (12 two urban PM2.5 samples collected during contrasting seasons (i.e., autumn/winter, AW spring/summer, SS). The distinct intrinsic potentials (OPs) and SS PM2.5, as evaluated in acellular conditions, closely related their respective physicochemical characteristics ability really generate ROS over-production mouse lungs. Despite activation nuclear factor erythroid 2-related 2 (Nrf2) cell signaling pathway and, lesser degree, murine lungs acute sub-chronic exposures, critical redox homeostasis was not restored, cessation. Accordingly, an inflammatory response reported through factor-kappa B (NF-κB) activation, secretion cytokines, recruitment cells, exposures extent, which persisted period. Taken together, original results provided, for first time, new relevant insights that relatively high OPs, induced stress inflammation, admittedly at lower level thereby contributing occurrence molecular cellular events leading development and/or exacerbation future chronic lung diseases cancers.
Язык: Английский
Процитировано
19Journal of Hazardous Materials, Год журнала: 2023, Номер 454, С. 131466 - 131466
Опубликована: Апрель 23, 2023
Язык: Английский
Процитировано
18Heliyon, Год журнала: 2024, Номер 10(4), С. e25884 - e25884
Опубликована: Фев. 1, 2024
BackgroundHuman health is seriously threatened by particulate matter (PM) pollution, which a major environmental problem. A better indicator of biological responses to PM exposure than its mass alone the "oxidative potential (OP)," or ability oxidize target molecules. When reactive oxygen species (ROS) are generated in OP excess antioxidant capacity body due components such metals and organic species, it causes inflammation, deoxyribonucleic acid (DNA), proteins, lipids damage.MethodThe samples fine (PM2.5) collected from brick kiln site roadside Lahore, Pakistan. The carbon (OC) elemental (EC) were estimated analyzer (DRI 2001A) using thermal/optical transmittance (TOT) protocol. water-soluble (WSOC) concentration was determined total (Shimadzu TOC-L CPN). Ion chromatography (Dionex ICS–900) with conductivity detector used analyze anions (Cl−, NO3−, SO42−) cations (NH4+, Na+, K+, Mg2+, Ca2+). Inductively coupled plasma-mass spectrometry (iCAP TQ ICP-MS, Thermo Scientific) determine concentrations solution. dithiothreitol (DTT) consumption rate calculated spectrophotometer at wavelength 412 nm.ResultsThe mean PM2.5 reported 509.3 ± 32.3 μg/m3 467.5 24.9 μg/m3, average OC/EC ratio 1.9 0.4 2.1 0.1. primary (POC) contributed more OC secondary (SOC), indicated dominance combustion sources. anion equivalent (AE) cation (CE) that acidic both sites NO3− SO42−. DTT normalized (DTTm) air volume (DTTv) higher contribution ionic PM2.5. Carbonaceous sampling significantly correlated DTTv PM2.5, while metallic behaved differently. incremental lifetime cancer risk (ILCR) values (lung cancer) As Cr sites, ILCR value Cd exceeding permissible limits for adults children. daily dose (LADD) children, indicating children less vulnerable metals.ConclusionThe Pakistan' National Environmental Quality Standard (NEQS) posing local population. POC SOC Lahore 84.6%, 15.4% 84.4%, 15.6%. dominant residence poses lung Cr, As, sites. results this study provide important data evidence further evaluation risks road side Pakistan formulation efficient air-pollution control measures.
Язык: Английский
Процитировано
9Atmosphere, Год журнала: 2023, Номер 14(3), С. 425 - 425
Опубликована: Фев. 21, 2023
Fine particulate matter (PM2.5) is a major contributor to the degree of air pollution, and it associated with range adverse health impacts. Moreover, oxidative potential (OP, as tracer stress) PM2.5 has been thought be possible determinant its impact. In this study, OP 136 fine aerosol filter samples collected in Changzhou two seasons (spring summer) were determined using dithiothreitol (DTT) assay. Source apportionments DTT activity further performed. Our results showed that daily average ± standard deviation DTTv (volume-normalized activity) was 1.16 0.58 nmol/min/m3 0.85 0.16 spring summer, respectively, DTTm (mass-normalized 13.56 5.45 pmol/min/μg 19.97 6.54 respectively. The higher compared summer while opposite true for DTTm. Most detected components (including organic component, element NH4+, Mn, Cu, Zn, etc.) exhibited moderately positive correlation DTTv, but found An aerodyne high-resolution mass spectrometer (HP-AMS) deployed probe chemical properties water-soluble (WSOA). Positive matrix factorization (PMF) coupled multiple linear regression used obtain relative source contributions WSOA PM2.5. sensitivity sequences sources oxygenated (OOA) > biomass burning OA (BBOA) hydrocarbon-like (HOA) HOA nitrogen-enriched (NOA) OOA summer. PMF suggested highest contribution from traffic emissions both seasons. findings point importance secondary formation transition metals effects region. This study can provide an important reference adopting appropriate public policies regarding detrimental outcomes exposure
Язык: Английский
Процитировано
10Atmospheric Environment, Год журнала: 2023, Номер 314, С. 120122 - 120122
Опубликована: Окт. 1, 2023
Язык: Английский
Процитировано
10The Science of The Total Environment, Год журнала: 2024, Номер 928, С. 172345 - 172345
Опубликована: Апрель 16, 2024
Fine particulate matter (PM
Процитировано
4Environment International, Год журнала: 2024, Номер 193, С. 109102 - 109102
Опубликована: Окт. 28, 2024
Язык: Английский
Процитировано
4Thermal Science, Год журнала: 2023, Номер 27(3 Part B), С. 2347 - 2357
Опубликована: Янв. 1, 2023
In numerous epidemiological studies, exposure to particulate matter (PM) has been associated with negative health outcomes. It established so far that the detrimental effects of particles cannot be explained by a single parameter, such as particle mass, complexity chemical composition and reactivity are not always represented mass loadings. The oxidative potential (OP) aerosol represents promising indicator their toxicity. To develop strategies regulations at improving air quality, an increasing number studies focused on application source apportionment (SA) PM., while limited SA investigations have applied OP. this review previous research atmospheric PM OP proposed guidelines for future summarized. Most were carried out in urban area PM2.5, few examined other fractions. was noted three dominant contributors biomass burning (9-97%), secondary aerosols (6-67%), traffic/vehicles (16-88%). presence factors contributed in-crease lesser extent depended location season. Further, considerable discrepancy contribution various vs. sources discovered using models. Because this, use is equivalent when considering its
Язык: Английский
Процитировано
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