Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Авг. 14, 2024
Mitochondria
are
crucial
organelles
responsible
for
energy
generation
in
eukaryotic
cells.
Oxidative
stress,
calcium
disorders,
and
mitochondrial
DNA
abnormalities
can
all
cause
dysfunction.
It
is
now
well
documented
that
dysfunction
significantly
contributes
to
the
pathogenesis
of
numerous
illnesses.
Hence,
it
vital
investigate
innovative
treatment
methods
targeting
Extracellular
vesicles
(EVs)
cell-derived
nanovesicles
serve
as
intercellular
messengers
classified
into
small
EVs
(sEVs,
<
200
nm)
large
(lEVs,
>
based
on
their
sizes.
worth
noting
certain
subtypes
rich
components
(even
structurally
intact
mitochondria)
possess
ability
transfer
them
or
other
contents
including
proteins
nucleic
acids
recipient
cells
modulate
function.
Specifically,
target
cell
homeostasis
mitochondria-controlled
apoptosis
ROS
by
delivering
relevant
substances.
In
addition,
artificial
modification
delivery
carriers
therapeutic
goods
mitochondria
also
a
current
research
hotspot.
this
article,
we
will
focus
function
cells,
aiming
offer
novel
perspectives
approaches
diverse
conditions
linked
Signal Transduction and Targeted Therapy,
Год журнала:
2022,
Номер
7(1)
Опубликована: Дек. 29, 2022
Sirtuins
(SIRTs)
are
nicotine
adenine
dinucleotide(+)-dependent
histone
deacetylases
regulating
critical
signaling
pathways
in
prokaryotes
and
eukaryotes,
involved
numerous
biological
processes.
Currently,
seven
mammalian
homologs
of
yeast
Sir2
named
SIRT1
to
SIRT7
have
been
identified.
Increasing
evidence
has
suggested
the
vital
roles
members
SIRT
family
health
disease
conditions.
Notably,
this
protein
plays
a
variety
important
cellular
biology
such
as
inflammation,
metabolism,
oxidative
stress,
apoptosis,
etc.,
thus,
it
is
considered
potential
therapeutic
target
for
different
kinds
pathologies
including
cancer,
cardiovascular
disease,
respiratory
other
Moreover,
identification
modulators
exploring
functions
these
prompted
increased
efforts
discover
new
small
molecules,
which
can
modify
activity.
Furthermore,
several
randomized
controlled
trials
indicated
that
interventions
might
affect
expression
human
samples,
supplementation
diverse
impact
on
physiological
function
participants.
In
review,
we
introduce
history
structure
family,
discuss
molecular
mechanisms
elaborate
regulatory
SIRTs
summarize
inhibitors
activators,
review
related
clinical
studies.
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
178, С. 117084 - 117084
Опубликована: Авг. 1, 2024
The
accumulation
of
excess
reactive
oxygen
species
(ROS)
can
lead
to
oxidative
stress
(OS),
which
induce
gene
mutations,
protein
denaturation,
and
lipid
peroxidation
directly
or
indirectly.
expression
is
reduced
ATP
level
in
cells,
increased
cytoplasmic
Ca
Aging and Disease,
Год журнала:
2023,
Номер
14(6), С. 2193 - 2193
Опубликована: Янв. 1, 2023
Increasing
evidence
has
shown
that
gut
dysbacteriosis
may
play
a
crucial
role
in
neuroinflammation
Parkinson's
disease
(PD).
However,
the
specific
mechanisms
link
microbiota
to
PD
remain
unexplored.
Given
critical
roles
of
blood-brain
barrier
(BBB)
dysfunction
and
mitochondrial
development
PD,
we
aimed
evaluate
interactions
among
microbiota,
BBB,
resistance
oxidation
inflammation
PD.
We
investigated
effects
fecal
transplantation
(FMT)
on
physiopathology
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
(MPTP)-treated
mice.
The
aim
was
explore
from
patients
healthy
human
controls
neuroinflammation,
BBB
components,
antioxidative
capacity
via
AMPK/SOD2
pathway.
Compared
control
mice,
MPTP-treated
mice
exhibited
elevated
levels
Desulfovibrio,
whereas
given
FMT
enriched
Akkermansia
humans
showed
no
significant
alterations
microbiota.
Strikingly,
significantly
aggravated
motor
impairments,
dopaminergic
neurodegeneration,
nigrostriatal
glial
activation
colonic
inflammation,
inhibited
signaling
greatly
improved
aforementioned
MPTP-caused
effects.
Surprisingly,
displayed
loss
pericytes,
which
restored
by
controls.
Our
findings
demonstrate
can
correct
ameliorate
neurodegeneration
MPTP-induced
mouse
model
suppressing
microgliosis
astrogliosis,
ameliorating
impairments
pathway,
restoring
pericytes
integrity.
These
raise
possibility
alteration
be
risk
factor
for
provide
potential
application
preclinical
treatment.
Hepatology Communications,
Год журнала:
2024,
Номер
8(7)
Опубликована: Июль 1, 2024
With
an
increasing
prevalence,
metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)
has
become
a
major
global
health
problem.
MASLD
is
well-known
as
multifactorial
disease.
Mitochondrial
dysfunction
and
alterations
in
the
gut
bacteria
are
2
vital
events
MASLD.
Recent
studies
have
highlighted
cross-talk
between
microbiota
mitochondria,
mitochondria
recognized
pivotal
targets
of
to
modulate
host's
physiological
state.
plays
role
associated
with
multiple
pathological
changes,
including
hepatocyte
steatosis,
oxidative
stress,
inflammation,
fibrosis.
Metabolites
crucial
mediators
that
influence
extraintestinal
organs.
Additionally,
regulation
composition
may
serve
promising
therapeutic
strategy
for
This
study
reviewed
potential
roles
several
common
metabolites
MASLD,
emphasizing
their
impact
on
mitochondrial
function.
Finally,
we
discuss
current
treatments
probiotics,
prebiotics,
antibiotics,
fecal
transplantation.
These
methods
concentrate
restoring
promote
host
health.
