MAPK/NF-κB signaling mediates atrazine-induced cardiorenal syndrome and antagonism of lycopene DOI
Fuwei Jiang, Jianying Guo,

Jia Lin

и другие.

The Science of The Total Environment, Год журнала: 2024, Номер 922, С. 171015 - 171015

Опубликована: Фев. 16, 2024

Язык: Английский

Transcriptome and proteome analyses reveal the mechanisms involved in polystyrene nanoplastics disrupt spermatogenesis in mice DOI

Sheng Ma,

Lirui Wang, Sisi Li

и другие.

Environmental Pollution, Год журнала: 2023, Номер 342, С. 123086 - 123086

Опубликована: Дек. 5, 2023

Язык: Английский

Процитировано

17
METTL3-m6A-SIRT1 axis affects autophagic flux contributing to PM2.5-induced inhibition of testosterone production in Leydig cells DOI

Lianlian Jiang,

Xiaojun Lin,

Jinchen Jiang

и другие.

The Science of The Total Environment, Год журнала: 2024, Номер 918, С. 170701 - 170701

Опубликована: Фев. 5, 2024

Язык: Английский

Процитировано

8
Long-term exposure to the mixture of phthalates induced male reproductive toxicity in rats and the alleviative effects of quercetin DOI
Lilan Liu,

Jun‐Zhe Yue,

Zhenyu Lu

и другие.

Toxicology and Applied Pharmacology, Год журнала: 2024, Номер 483, С. 116816 - 116816

Опубликована: Янв. 11, 2024

Язык: Английский

Процитировано

7
Melatonin Mitigates Atrazine-Induced Renal Tubular Epithelial Cell Senescence by Promoting Parkin-Mediated Mitophagy DOI Creative Commons
Yu-Sheng Shi,

Tian‐Ning Yang,

Yuxiang Wang

и другие.

Research, Год журнала: 2024, Номер 7

Опубликована: Янв. 1, 2024

The accumulation of senescent cells in kidneys is considered to contribute age-related diseases and organismal aging. Mitochondria are a regulator cell senescence process. Atrazine as triazine herbicide poses threat renal health by disrupting mitochondrial homeostasis. Melatonin plays critical role maintaining present study aims explore the mechanism which melatonin alleviates atrazine-induced injury whether parkin-mediated mitophagy contributes mitigating senescence. found that level parkin was decreased after atrazine exposure negatively correlated with markers. treatment increased serum levels mitigates tubular epithelial Mechanistically, maintains integrity crista structure increasing contact site cristae organizing system, transcription factor A (TFAM), adenosine triphosphatase family AAA domain-containing protein 3A (ATAD3A), sorting assembly machinery 50 (Sam50) prevent DNA release subsequent activation cyclic guanosine 5′-monophosphate–adenosine 5′-monophosphate synthase pathway. Furthermore, activates Sirtuin 3–superoxide dismutase 2 axis eliminate reactive oxygen species kidney. More importantly, antisenescence largely determined parkin-dependent mitophagy. These results offer novel insights into measures against Parkin-mediated promising drug target for alleviating

Язык: Английский

Процитировано

7
MAPK/NF-κB signaling mediates atrazine-induced cardiorenal syndrome and antagonism of lycopene DOI
Fuwei Jiang, Jianying Guo,

Jia Lin

и другие.

The Science of The Total Environment, Год журнала: 2024, Номер 922, С. 171015 - 171015

Опубликована: Фев. 16, 2024

Язык: Английский

Процитировано

6