Autophagy and PPARs/NF-κB-associated inflammation are involved in hepatotoxicity induced by the synthetic phenolic antioxidant 2,4-di-tert-butylphenol in common carp (Cyprinus carpio) DOI Creative Commons
Jiaqi Xie,

Yuxiang Yin,

Bixiao Lin

и другие.

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 284, С. 116937 - 116937

Опубликована: Сен. 2, 2024

The synthetic phenolic antioxidant 2,4-di-tert-butylphenol (2,4-DTBP) is an emergent contaminant and can disrupt the delicate balance of aquatic ecosystems. This study aimed to investigate 2,4-DTBP-induced hepatotoxicity in common carp underlying mechanisms involved. Sixty were divided into four groups exposed 0 mg/L, 0.01 0.1 mg/L or 1 2,4-DTBP for 30 days. Here, we first demonstrated that exposure caused liver damage, manifested as hepatocyte nuclear pyknosis, inflammatory cell infiltration apoptosis. Moreover, induced hepatic reactive oxygen species (ROS) overload disrupted capacity, indicated by reduced activity enzymes superoxide dismutase (SOD), catalase (CAT) glutathione peroxidase (GSH-Px). In addition, transmission electron microscopy revealed autophagosome accumulation carp. Western blot analysis further significantly decreased protein levels mTOR increased LC3II/LC3I ratio. Furthermore, inhibited lysozyme (LZM) alkaline phosphatase (AKP) activity; immunoglobulin M (IgM), complement 3 (C3), 4 (C4) serum; mRNA proinflammatory cytokines (NF-κB, TNF-α, IL-1β IL-6); three types proliferator-activated receptors (PPARs) (α, β/δ γ). Molecular docking directly binds internal active pocket PPARs. Overall, concluded systems could induce regulating autophagy controlling responses. present provides new insights mechanism organisms furthers our understanding effects on public health ecotoxicology.

Язык: Английский

Lycopene as a Therapeutic Agent against Aflatoxin B1-Related Toxicity: Mechanistic Insights and Future Directions DOI Creative Commons
Meng Li, Shusheng Tang,

Xinyan Peng

и другие.

Antioxidants, Год журнала: 2024, Номер 13(4), С. 452 - 452

Опубликована: Апрель 11, 2024

Aflatoxin (AFT) contamination poses a significant global public health and safety concern, prompting widespread apprehension. Of the various AFTs, aflatoxin B1 (AFB1) stands out for its pronounced toxicity association with spectrum of chronic ailments, including cardiovascular disease, neurodegenerative disorders, cancer. Lycopene, lipid-soluble natural carotenoid, has emerged as potential mitigator deleterious effects induced by AFB1 exposure, spanning cardiac injury, hepatotoxicity, nephrotoxicity, intestinal damage, reproductive impairment. This protective mechanism operates reducing oxidative stress, inflammation, lipid peroxidation, activating mitochondrial apoptotic pathway, facilitating activation biogenesis, endogenous antioxidant system, nuclear factor erythroid 2-related 2 (Nrf2)/kelch-like ECH-associated protein 1 (KEAP1) peroxisome proliferator-activated receptor-γ coactivator-1 (PGC-1) pathways, well regulating activities cytochrome P450 (CYP450) enzymes. review provides an overview lycopene against exposure-induced underlying molecular mechanisms. Furthermore, it explores profile clinical applications lycopene. The present underscores lycopene’s promising detoxification agent intent to stimulate further research practical utilization in this domain.

Язык: Английский

Процитировано

9
Exposure to glyphosate causes hypoxia in crustaceans by targeting hemocyanin DOI

Rui-Geng Niu,

Cheng-Ming Yin,

Jia-Yu Si

и другие.

Aquaculture, Год журнала: 2025, Номер unknown, С. 742314 - 742314

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Cadmium disrupted homeostasis of proximal renal tubular cells via targeting ATF4-CHOP complex into the nucleus DOI Creative Commons

Muhammad Asmat Ullah Saleem,

Yingxin Zhao,

Farhat Bano

и другие.

Poultry Science, Год журнала: 2025, Номер unknown, С. 105059 - 105059

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Lycopene mitigates atrazine-induced hypothalamic neural stem cell senescence by modulating the integrated stress response pathway DOI
Jian Chen, Xueyan Dai, Xiao‐Wei Li

и другие.

Phytomedicine, Год журнала: 2024, Номер 135, С. 156114 - 156114

Опубликована: Сен. 30, 2024

Язык: Английский

Процитировано

3
Accumulated inflammation and fibrosis participate in atrazine induced ovary toxicity in mice DOI

Yi-Fan Yang,

Si-Yao Cheng,

Yalong Wang

и другие.

Environmental Pollution, Год журнала: 2024, Номер 360, С. 124672 - 124672

Опубликована: Авг. 3, 2024

Язык: Английский

Процитировано

1
Autophagy and PPARs/NF-κB-associated inflammation are involved in hepatotoxicity induced by the synthetic phenolic antioxidant 2,4-di-tert-butylphenol in common carp (Cyprinus carpio) DOI Creative Commons
Jiaqi Xie,

Yuxiang Yin,

Bixiao Lin

и другие.

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 284, С. 116937 - 116937

Опубликована: Сен. 2, 2024

The synthetic phenolic antioxidant 2,4-di-tert-butylphenol (2,4-DTBP) is an emergent contaminant and can disrupt the delicate balance of aquatic ecosystems. This study aimed to investigate 2,4-DTBP-induced hepatotoxicity in common carp underlying mechanisms involved. Sixty were divided into four groups exposed 0 mg/L, 0.01 0.1 mg/L or 1 2,4-DTBP for 30 days. Here, we first demonstrated that exposure caused liver damage, manifested as hepatocyte nuclear pyknosis, inflammatory cell infiltration apoptosis. Moreover, induced hepatic reactive oxygen species (ROS) overload disrupted capacity, indicated by reduced activity enzymes superoxide dismutase (SOD), catalase (CAT) glutathione peroxidase (GSH-Px). In addition, transmission electron microscopy revealed autophagosome accumulation carp. Western blot analysis further significantly decreased protein levels mTOR increased LC3II/LC3I ratio. Furthermore, inhibited lysozyme (LZM) alkaline phosphatase (AKP) activity; immunoglobulin M (IgM), complement 3 (C3), 4 (C4) serum; mRNA proinflammatory cytokines (NF-κB, TNF-α, IL-1β IL-6); three types proliferator-activated receptors (PPARs) (α, β/δ γ). Molecular docking directly binds internal active pocket PPARs. Overall, concluded systems could induce regulating autophagy controlling responses. present provides new insights mechanism organisms furthers our understanding effects on public health ecotoxicology.

Язык: Английский

Процитировано

0