Frontiers in Microbiology,
Год журнала:
2024,
Номер
15
Опубликована: Май 9, 2024
Background
Anorexia
nervosa
(AN)
and
bulimia
(BN)
poses
a
significant
challenge
to
global
public
health.
Despite
extensive
research,
conclusive
evidence
regarding
the
association
between
gut
microbes
risk
of
AN
BN
remains
elusive.
Mendelian
randomization
(MR)
methods
offer
promising
avenue
for
elucidating
potential
causal
relationships.
Materials
Genome-wide
studies
(GWAS)
datasets
were
retrieved
from
OpenGWAS
database
analysis.
Independent
single
nucleotide
polymorphisms
closely
associated
with
196
bacterial
taxa
MiBioGen
consortium
identified
as
instrumental
variables.
MR
analysis
was
conducted
utilizing
R
software,
outlier
exclusion
performed
using
MR-PRESSO
method.
Causal
effect
estimation
undertaken
employing
four
methods,
including
Inverse
variance
weighted.
Sensitivity
analysis,
heterogeneity
horizontal
multivariate
assessment
directionality
carried
out
assess
robustness
findings.
Results
A
total
spanning
six
taxonomic
levels
subjected
Nine
demonstrating
relationships
identified.
Among
these,
five
taxa,
Peptostreptococcaceae
,
implicated
exerting
on
risk,
while
Gammaproteobacteria
reduced
AN.
Similarly,
nine
exhibiting
Of
Clostridiales
factors
increased
three
Oxalobacteraceae
deemed
protective
factors.
Lachnospiraceae
emerged
common
influence
both
BN,
albeit
opposing
effects.
No
or
pleiotropy
detected
estimates.
Conclusion
Through
we
revealed
role
18
intestinal
in
.
It
provides
new
insights
into
mechanistic
basis
intervention
targets
microbiota-mediated
BN.
Nutrients,
Год журнала:
2024,
Номер
16(14), С. 2343 - 2343
Опубликована: Июль 19, 2024
Hesperetin
(HT)
is
a
type
of
citrus
flavonoid
with
various
pharmacological
activities,
including
anti-tumor,
anti-inflammation,
antioxidant,
and
neuroprotective
properties.
However,
the
role
mechanism
HT
in
ulcerative
colitis
(UC)
have
been
rarely
studied.
Our
study
aimed
to
uncover
beneficial
effects
its
detailed
UC.
Experimental
was
induced
by
2.5%
dextran
sodium
sulfate
(DSS)
for
seven
days.
ameliorated
DSS-induced
mice,
showing
marked
improvement
weight
loss,
colon
length,
colonic
pathological
severity,
levels
TNFα
IL6
serum.
A
combination
informatics,
network
pharmacology,
molecular
docking
identified
eight
key
targets
multi-pathways
influenced
As
highlight,
experimental
validation
demonstrated
that
PTGS2,
marker
ferroptosis,
along
other
indicators
ferroptosis
(such
as
ACSL4,
Gpx4,
lipid
peroxidation),
were
regulated
vivo
vitro.
Additionally,
supplement
increased
diversity
gut
microbiota,
decreased
relative
abundance
Proteobacteria
Gammaproteobacteria,
restored
bacteria
(Lachnospiraceae_NK4A136_group
Prevotellaceae_UCG-001).
In
conclusion,
an
effective
nutritional
against
suppressing
modulating
microbiota.
Foods,
Год журнала:
2025,
Номер
14(5), С. 794 - 794
Опубликована: Фев. 26, 2025
This
study
was
conducted
to
investigate
the
effects
and
mechanisms
of
all-trans
lycopene
on
intestinal
health
by
establishing
lipopolysaccharide-induced
(LPS-induced)
jejunal
inflammation
model.
Dietary
supplementation
enhanced
serum
jejunum
antioxidant
capacity.
Lycopene
significantly
reduced
LPS-induced
upregulation
toll-like
receptor-4
(TLR-4)
nuclear
factor
kappa-B
(NF-κB),
suggesting
that
activation
TLR-4/NF-κB
signaling
pathway
induced
LPS
challenge,
further
protected
mice
from
inflammation.
Furthermore,
increased
zonula
occludens-1
(ZO-1)
protein
expression
abundance
Rikenella,
Lachnospiraceae_NK4A136_group
Mucispirillum
potentially
associated
with
reducing
gut
Overall,
these
results
showed
pretreatment
can
improve
ensure
in
improving
capacity,
barrier
function,
microorganisms
anti-inflammatory
LPS.
We
provided
a
new
insight
into
prevented
corresponding
alterations
metabolites
microbiota,
capacity
regulating
mice.
