Lycopene Protects against Atrazine-Induced Kidney STING-Dependent PANoptosis through Stabilizing mtDNA via Interaction with Sam50/PHB1
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(26), С. 14956 - 14966
Опубликована: Май 31, 2024
Atrazine
(ATR)
is
a
widely
used
herbicide
worldwide
that
can
cause
kidney
damage
in
humans
and
animals
by
accumulation
water
soil.
Lycopene
(LYC),
carotenoid
with
numerous
biological
activities,
plays
an
important
role
protection
due
to
its
potent
antioxidant
anti-inflammatory
effects.
The
current
study
sought
investigate
the
of
interactions
between
mtDNA
cGAS-STING
signaling
pathway
LYC
mitigating
PANoptosis
inflammation
kidneys
induced
ATR
exposure.
In
our
research,
350
mice
were
orally
administered
(5
mg/kg
BW/day)
(50
or
200
for
21
days.
Our
results
reveal
exposure
induces
decrease
stability,
resulting
release
into
cytoplasm
through
mPTP
pore
BAX
mobilization
pathway,
thereby
inducing
renal
inflammation.
inhibit
above
changes
caused
ATR.
conclusion,
inhibited
exposure-induced
histopathological
changes,
PANoptosis,
inhibiting
pathway.
demonstrate
positive
ATR-induced
injury
provide
new
therapeutic
target
treating
diseases
clinic.
Язык: Английский
Effect of microcystin-LR on intestinal microbiota, metabolism, and health of zebrafish (Danio rerio)
The Science of The Total Environment,
Год журнала:
2025,
Номер
967, С. 178838 - 178838
Опубликована: Фев. 12, 2025
Язык: Английский
Mechanistic target of rapamycin/blood-testes barrier mechanism mediates acceleration of sperm epigenetic aging by environmental factors
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Abstract
Our
previous
research
suggested
that
mechanistic
target
of
rapamycin
(mTOR)/blood-testis
barrier
(BTB)
mechanism
is
involved
in
the
regulation
rates
epigenetic
aging
sperm,
where
increased
activity
mTORC1
opens
BTB
and
accelerates
mTORC2
produces
opposite
results
–
increases
integrity
rejuvenates
sperm
epigenome.
In
present
study,
we
use
our
newly
developed
clock
model
to
investigate
whether
mTOR/BTB
reprogramming
mice
exposed
heat
stress
(HS)
cadmium
(Cd).
findings
show
both
mTOR-dependent
disruption
caused
by
HS
mTOR-independent
due
Cd
exposure
accelerate
aging,
resulting
similar
changes
DNA
methylation
patterns.
These
suggest
a
novel
molecular
pathway
through
which
environmental
stressors
influence
this
may
be
relevant
broad
range
factors,
including
environmental,
lifestyle,
dietary,
health
influences.
Язык: Английский
Cadmium causes cerebral mitochondrial dysfunction through regulating mitochondrial HSF1
Environmental Pollution,
Год журнала:
2024,
Номер
360, С. 124677 - 124677
Опубликована: Авг. 8, 2024
Язык: Английский
Environmental toxins and reproductive health: Unraveling the effects on Sertoli cells and the blood-testis barrier in animals
Biology of Reproduction,
Год журнала:
2024,
Номер
111(5), С. 977 - 986
Опубликована: Авг. 23, 2024
Abstract
Environmental
pollution
is
an
inevitable
ecological
issue
accompanying
the
process
of
socialization,
with
increasing
attention
to
its
impacts
on
individual
organisms
and
chains.
The
reproductive
system,
responsible
for
transmitting
genetic
material
in
animals,
one
most
sensitive
systems
environmental
toxins.
Research
reveals
that
Sertoli
cells
are
primary
target
action
Different
toxins
mostly
affect
blood–testis
barrier
lead
male
disorders
by
disrupting
cells.
Therefore,
this
article
provides
in-depth
exploration
toxic
mechanisms
various
types
testes.
It
dynamic
processes
tight
junctions
affected
their
specific
roles
reconstruction
process.
Язык: Английский
Cadmium Exposure Induces Inflammation Through Oxidative Stress-Mediated Activation of the NF-κB Signaling Pathway and Causes Heat Shock Response in a Piglet Testis
Biological Trace Element Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 4, 2024
Язык: Английский
Oxidative Stress and Autophagy: Unraveling the Hidden Threat to Boars’ Fertility
Antioxidants,
Год журнала:
2024,
Номер
14(1), С. 2 - 2
Опубликована: Дек. 24, 2024
This
review
systematically
examines
the
influence
of
oxidative
stress
on
reproductive
function
male
livestock,
with
a
particular
focus
modulation
autophagy.
Spermatogenesis,
highly
precise
biological
process,
is
vulnerable
to
range
internal
and
external
factors,
among
which
notably
disrupts
autophagic
processes
within
testes.
disruption
results
in
diminished
sperm
quality,
impaired
testosterone
synthesis,
compromised
integrity
blood–testis
barrier.
Furthermore,
this
elucidates
molecular
mechanisms
by
stress-induced
autophagy
dysfunction
impairs
spermatogenesis
mitochondrial
function,
consequently
reducing
motility.
These
findings
aim
provide
theoretical
foundation
serve
as
reference
for
improving
performance
quality
livestock.
Язык: Английский
Cadmium causes spleen toxicity in chickens by regulating mitochondrial unfolded protein response and nuclear receptors response
Poultry Science,
Год журнала:
2024,
Номер
103(11), С. 104167 - 104167
Опубликована: Авг. 3, 2024
Cadmium
(Cd)
is
a
heavy
metal
that
pollutes
the
environment
and
threatens
human
animal
health
via
food
chain.
The
spleen
one
of
target
organs
affected
by
Cd
toxicity.
However,
mechanism
toxicity
not
fully
understood.
In
this
study,
80
chicks
were
allocated
into
4
groups
(n
=
20)
exposed
to
different
doses
CdCl
Язык: Английский
Chronic dietary exposure to glyphosate-induced connexin 43 autophagic degradation contributes to blood-testis barrier disruption in roosters
The Science of The Total Environment,
Год журнала:
2024,
Номер
951, С. 175606 - 175606
Опубликована: Авг. 17, 2024
Язык: Английский
Metasilicate-based alkaline mineral water improves the growth performance of weaned piglets by maintaining gut-liver axis homeostasis through microbiota-mediated secondary bile acid pathway
Animal nutrition,
Год журнала:
2024,
Номер
20, С. 95 - 109
Опубликована: Ноя. 2, 2024
Weaning
stress
causes
substantial
economic
loss
in
the
swine
industry.
Moreover,
weaning-induced
intestinal
barrier
damage
and
dysfunction
of
gut-liver
axis
are
associated
with
reduced
growth
performance
piglets.
Metasilicate-based
alkaline
mineral
water
(AMW)
has
shown
potential
therapeutic
effects
on
gastrointestinal
disorders;
however,
mechanisms
involved
their
overall
have
not
been
explored.
Here,
sodium
metasilicate
(SMS)
was
used
to
prepare
metasilicate-based
AMW
(basal
+
500
mg/L
SMS).
A
total
240
newly
weaned
piglets
were
allocated
Control
SMS
groups
(6
replicate
pens
per
group
20
pen)
for
a
15-day
trial
period.
Histopathological
evaluations
conducted
using
hematoxylin
eosin
staining.
To
analyze
composition
gut
microbiota,
16S
rRNA
PacBio
SMRT
Gene
Full-Length
Sequencing
performed.
Western
blotting
immunofluorescence
employed
assess
protein
expression
levels.
Our
results
indicated
that
effectively
alleviated
colonic
or
liver
morphological
injury
inflammatory
response,
as
well
cholesterol
metabolism
disorders.
Further
analysis
showed
promoted
deoxycholic
acid
(DCA)
biosynthesis
by
increasing
abundance
Lactobacillus_delbrueckii
colon
(P
<
0.001).
This
consequently
improved
through
DCA-secondary
bile
(SBA)
receptors
(SBAR)-nuclear
factor-kappaB
(NF-κB)/NOD-like
receptor
family
pyrin
domain-containing
3
(NLRP3)
pathways.
Growth
parameters,
including
final
body
weight
=
0.034)
average
daily
gain
0.001),
significantly
higher
than
those
group.
Therefore,
maintains
homeostasis
regulating
microbiota-mediated
SBA-SBAR
pathway
under
weaning
stress.
research
provides
new
strategy
mitigating
stress-induced
Язык: Английский