Galleria mellonella (Greater Wax Moth) as a Reliable Animal Model to Study the Efficacy of Nanomaterials in Fighting Pathogens
Nanomaterials,
Год журнала:
2025,
Номер
15(1), С. 67 - 67
Опубликована: Янв. 3, 2025
The
spread
of
multidrug-resistant
microbes
has
made
it
necessary
and
urgent
to
develop
new
strategies
deal
with
the
infections
they
cause.
Some
these
are
based
on
nanotechnology,
which
revolutionized
many
fields
in
medicine.
Evaluating
safety
efficacy
antimicrobial
requires
testing
animal
models
before
being
tested
clinical
trials.
In
this
context,
Galleria
mellonella
could
represent
a
valid
alternative
traditional
mammalian
non-mammalian
models,
due
its
low
cost,
ease
handling,
valuable
biological
properties
investigate
host–pathogen
interactions.
purpose
review
is
provide
an
updated
overview
literature
concerning
use
G.
larvae
as
model
evaluate
nanoparticles
nanomaterials,
particularly,
those
that
used
or
under
investigation
combat
microbial
pathogens.
Язык: Английский
Exploring Environmental Behaviors and Health Impacts of Biodegradable Microplastics
Environmental Science & Technology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 21, 2025
Biodegradable
plastics
(BPs)
are
promoted
as
eco-friendly
alternatives
to
conventional
plastics.
However,
compared
microplastics
(MPs),
they
degrade
rapidly
into
biodegradable
(BMPs),
which
may
lead
a
more
significant
accumulation
of
BMPs
in
the
environment.
This
review
systematically
compares
and
MPs,
summarizes
current
knowledge
on
their
environmental
behaviors
impacts
ecosystems
human
health,
offers
recommendations
for
future
research.
detected
water,
sediments,
indoor
dust,
food,
marine
organisms,
samples.
Compared
prone
transformations,
such
photodegradation
biodegradation,
results
shorter
migration
distance
across
different
matrices.
Like
can
adsorb
pollutants
transport
them
enhancing
toxicity
health
risks
through
Trojan
horse
effect.
Studies
indicate
that
negatively
impact
terrestrial
aquatic
than
MPs
by
disrupting
nutrient
cycling
inhibiting
plant
animal
growth.
In
vivo
vitro
research
also
shows
BMP
degradation
products
increase
bioavailability,
exacerbating
neurotoxicity
overall
toxicity.
findings
BMPs'
effects
remain
inconsistent.
Further
evaluation
trade-offs
between
biodegradability
is
needed
address
these
uncertainties.
Язык: Английский
Assessing toxicity of amorphous nanoplastics in airway- and lung epithelial cells using air-liquid interface models
Chemosphere,
Год журнала:
2024,
Номер
368, С. 143702 - 143702
Опубликована: Ноя. 1, 2024
Inhalation
is
one
of
the
main
exposure
routes
to
nanoplastics.
Knowledge
toxicological
impact
nanoplastics
on
airway-
and
lung
epithelium
limited
almost
exclusively
based
submerged
in
vitro
models
using
spherical
polystyrene
(PS)
particles.
Язык: Английский
PM10-bound microplastics and trace metals: A public health insight from the Korean subway and indoor environments
Journal of Hazardous Materials,
Год журнала:
2024,
Номер
477, С. 135156 - 135156
Опубликована: Июль 11, 2024
Язык: Английский
Silicone-modified poly(lactic acid) fibrous membranes for oil-water separation: Hydrolysis and wetting behavior analysis
Materials Chemistry and Physics,
Год журнала:
2024,
Номер
333, С. 130271 - 130271
Опубликована: Дек. 24, 2024
Язык: Английский
THE EFFECT OF NANOPLASTICS AND MICROPLASTICS ON LUNG MORPHOLOGY AND PHYSIOLOGY: A SYSTEMATIC REVIEW
The Medical and Ecological Problems,
Год журнала:
2024,
Номер
28(3), С. 42 - 60
Опубликована: Дек. 30, 2024
Airborne
microplastic
(NP)
and
nanoplastic
(MP)
pollution
has
emerged
as
a
pressing
environmental
concern
with
significant
implications
for
human
health.
While
MPs
are
present
both
indoors
outdoors,
indoor
concentrations
generally
higher
due
to
the
abrasion
of
household
materials,
furniture,
other
domestic
sources.
NPs,
when
inhaled,
accumulate
in
various
lung
regions,
exerting
toxic
effects
potentially
leading
respiratory
diseases.
This
systematic
review,
conducted
according
PRISMA
guidelines,
evaluates
recent
experimental
studies
on
pathogenic
impact
nanomicroplastics
(NMPs)
tissues
using
vivo
vitro
models.
The
review
included
10
analyzing
MP
accumulation
90
examining
pathogenetic
mechanisms
exposure.
Research
data
indicates
predominance
polymeric
fibers
such
polypropylene,
polyethylene
terephthalate,
polytetrafluoroethylene,
accounting
nearly
half
structures.
NMPs
exhibit
size-
composition-dependent
accumulation,
smaller
positively
charged
particles
showing
translocation
potential
systemic
circulation
organs.
highlights
synergistic
heavy
metals
pollutants,
interaction
pulmonary
surfactant,
role
exacerbating
Current
analysis
underscores
growing
interest
NMP-related
health
risks
identifies
knowledge
gaps,
including
need
standardization
NMP
toxicity
testing
further
exploration
biological
systems.
findings
emphasize
importance
mitigating
exposure
safeguard
pave
way
future
research
long-term
impacts
airborne
Язык: Английский