The Medical and Ecological Problems,
Год журнала:
2024,
Номер
28(3), С. 42 - 60
Опубликована: Дек. 30, 2024
Airborne
microplastic
(NP)
and
nanoplastic
(MP)
pollution
has
emerged
as
a
pressing
environmental
concern
with
significant
implications
for
human
health.
While
MPs
are
present
both
indoors
outdoors,
indoor
concentrations
generally
higher
due
to
the
abrasion
of
household
materials,
furniture,
other
domestic
sources.
NPs,
when
inhaled,
accumulate
in
various
lung
regions,
exerting
toxic
effects
potentially
leading
respiratory
diseases.
This
systematic
review,
conducted
according
PRISMA
guidelines,
evaluates
recent
experimental
studies
on
pathogenic
impact
nanomicroplastics
(NMPs)
tissues
using
vivo
vitro
models.
The
review
included
10
analyzing
MP
accumulation
90
examining
pathogenetic
mechanisms
exposure.
Research
data
indicates
predominance
polymeric
fibers
such
polypropylene,
polyethylene
terephthalate,
polytetrafluoroethylene,
accounting
nearly
half
structures.
NMPs
exhibit
size-
composition-dependent
accumulation,
smaller
positively
charged
particles
showing
translocation
potential
systemic
circulation
organs.
highlights
synergistic
heavy
metals
pollutants,
interaction
pulmonary
surfactant,
role
exacerbating
Current
analysis
underscores
growing
interest
NMP-related
health
risks
identifies
knowledge
gaps,
including
need
standardization
NMP
toxicity
testing
further
exploration
biological
systems.
findings
emphasize
importance
mitigating
exposure
safeguard
pave
way
future
research
long-term
impacts
airborne
Research Square (Research Square),
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Abstract
The
rise
of
food
delivery
culture
has
resulted
in
millions
tons
food-contact
plastic
containers
being
used
each
year,
yet
the
risks
micro(nano)plastics
(MNPs)
released
during
storage
oil-rich
foods
are
still
not
well
understood.
Here,
we
investigated
MNP
release
from
polypropylene
(PP)
and
polyethylene
(PE)-coated
under
simulated
takeout
scenarios.
When
exposed
to
cooking
oil
microwave
heating,
up
125-fold
more
MNPs
471-fold
heavy
metals
compared
water
exposure,
with
significantly
altered
physicochemical
properties.
Oil-derived
PP
NPs,
uniquely
encapsulated
films
positive
surface
charge
(+7.37
mV).
oil-derived
NPs
may
enhance
their
interaction
negatively
charged
cell
membranes,
leading
rapid
death
within
5
minutes
at
a
concentration
100
μg/mL
through
membrane
disruption.
Transcriptomic
analysis
revealed
that
oil-PP
triggered
substantially
extensive
gene
expression
changes
than
water-derived
particularly
pathways
related
acute
cellular
stress
mitochondrial
energy
metabolism.
Global
exposure
assessments
highlight
annual
human
intake
3.35
g
food.
Based
on
integrated
molecular
endpoints,
established
benchmark
dose
lower
limit
(BMDL)
1.18
for
NPs.
abundance
biological
samples
exceeds
BMDL
thresholds,
suggesting
significant
health
risks.
Our
findings
reveal
previously
unknown
mechanisms
toxicity
underscore
urgent
need
stricter
regulation
packaging
foods.
Journal of Pharmaceutical Analysis,
Год журнала:
2024,
Номер
15(2), С. 101148 - 101148
Опубликована: Ноя. 14, 2024
Microplastics
and
nanoplastics
(MPs/NPs)
are
ubiquitous
environmental
pollutants
that
act
as
endocrine-disrupting
chemicals
(EDCs),
raising
significant
concerns
about
their
impact
on
human
health.
Research
highlights
the
hazardous
effects
of
MPs/NPs
both
male
female
reproductive
systems,
influencing
germ
cells,
embryo
development,
progeny.
Additionally,
studies
show
affect
gene
expression
anabolic
steroid
hormones
in
vitro
vivo,
inducing
toxicity
through
mechanisms
such
oxidative
stress
inflammation.
Considering
these
adverse
effects,
identifying
natural
compounds
can
mitigate
is
increasingly
important.
Plants
offer
a
wealth
antioxidants
anti-inflammatory
counteract
harmful
effects.
Among
these,
anthocyanins,
colorants
responsible
for
vibrant
hues
fruits
flowers,
exhibit
wide
range
biological
activities,
including
antioxidant,
anti-inflammatory,
anti-neoplastic
properties.
Moreover,
anthocyanins
modulate
sex
hormone
levels
alleviate
toxicity.
Cyanidin-3-glucoside
(C3G),
one
most
extensively
studied
shows
promise
reducing
toxicity,
particularly
females,
protecting
organs,
testis
epididymis.
This
protective
effect
believed
to
result
from
its
interaction
with
receptors,
specifically
androgen
estrogen
receptors
(ERs).
These
findings
highlight
need
explore
by
which
caused
MPs/NPs.
review
provides
novel
insights
into
how
be
leveraged
lessen
contaminants
health,
especially
concerning
