Single nucleus RNA sequencing reveals cellular and molecular responses to vanadium exposure in duck kidneys

Journal of Hazardous Materials, Год журнала: 2024, Номер 480, С. 136492 - 136492

Опубликована: Ноя. 13, 2024

Язык: Английский

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Ginkgo biloba extract alleviates deltamethrin-induced testicular injury by upregulating SKP2 and inhibiting Beclin1-independent autophagy

Phytomedicine, Год журнала: 2024, Номер 135, С. 156245 - 156245

Опубликована: Ноя. 9, 2024

Язык: Английский

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Palliative potential of genistein to counteract endosulfan instigated colon toxicity via regulating TLR4/MyD88, JAK1/STAT3 and NF-κB pathway: A biochemical and histological approach

Tissue and Cell, Год журнала: 2025, Номер 93, С. 102730 - 102730

Опубликована: Янв. 10, 2025

Язык: Английский

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Based on the Sam50-MICOS-ATAD3-mtDNA axis: Exploring oligomeric proanthocyanidins to alleviate molybdenum and cadmium co-induced liver inflammation in sheep

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 141035 - 141035

Опубликована: Фев. 1, 2025

Язык: Английский

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New insights into ovarian regression-related mitochondrial dysfunction in the late-laying period

Poultry Science, Год журнала: 2025, Номер 104(4), С. 104938 - 104938

Опубликована: Фев. 22, 2025

Язык: Английский

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Pollutants in Microenvironmental Cellular Interactions During Liver Inflammation Cancer Transition and the Application of Multi-Omics Analysis

Toxics, Год журнала: 2025, Номер 13(3), С. 163 - 163

Опубликована: Фев. 25, 2025

This study categorizes pollutant-induced inflammation–cancer transition into three stages: non-alcoholic fatty liver disease (NAFLD), fibrosis, and hepatocellular carcinoma (HCC). It systematically reveals the temporal heterogeneity of damage. The findings indicate that pollutants not only directly damage hepatocytes but also modulate key cells in immune microenvironment, such as hepatic stellate (HSCs) Kupffer cells, thereby amplifying inflammatory fibrotic responses, ultimately accelerating progression HCC. Mechanistically, early stage primarily cause hepatocyte injury through oxidative stress lipid metabolism dysregulation. During fibrosis stage, promote by inducing extracellular matrix accumulation, while HCC they drive tumorigenesis via activation Wnt/β-catenin pathway p53 inactivation. Through multi-omics analyses, this identifies critical pathogenic molecules signaling pathways regulated pollutants, providing new insights their mechanisms, potential biomarkers, therapeutic targets. These offer valuable guidance for development diagnostic strategies diseases formulation environmental health risk prevention measures.

Язык: Английский

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UBA52 Mediates ribosomal DNA stability under hexavalent chromium exposure in occupational workers and cellular models

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 293, С. 118047 - 118047

Опубликована: Март 1, 2025

Язык: Английский

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Ochratoxin A-induced mitochondrial pathway apoptosis and ferroptosis by promoting glycolysis

APOPTOSIS, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

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Quercetin protects cadmium-induced kidney injury by regulating PI3K/AKT/mTOR and Nrf2/NQO1 pathways in rats

Journal of Functional Foods, Год журнала: 2025, Номер 128, С. 106808 - 106808

Опубликована: Апрель 8, 2025

Язык: Английский

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Visual indicator for the detection of methylmercury in blood: A critical biomarker for dietary exposure assessment

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 295, С. 118157 - 118157

Опубликована: Апрель 1, 2025

Methylmercury (MeHg), a significant dietary exposure biomarker, poses substantial threat to public health, primarily due the consumption of aquatic foods. Current detection methods are complex and unsuitable for on-site testing, necessitating development simple sensitive biosensor rapid screening. This study addresses this challenge by developing highly whole-cell detecting organic mercury in blood samples, offering both visual qualitative colorimetric quantitative assessments. We engineered based on mer operon deoxyviolacein (DV) pigment, optimizing its performance adjusting MerB expression level, screening host cells, incorporating biosurfactant rhamnolipid. The optimized achieved limit 0.195 nM exhibited linear response range 0.195-1.563 MeHg. is significantly below Provisional Tolerable Weekly Intake (PTWI) 1.6 μg/kg body weight per week established Joint FAO/WHO Expert Committee Food Additives (JECFA), ensuring reliable MeHg at concentrations well within safety threshold. Notably, demonstrated broad-spectrum capabilities, including natural synthetic organomercurials, which crucial assessing risks from various sources. advances novel detection, highlighting potential as critical tool contributing understanding food health.

Язык: Английский

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