Effect of glucose selenol on hepatic lipid metabolism disorder induced by heavy metal cadmium in male rats DOI

Xinyi Yang,

Jinzhou Huang, Juan Wang

et al.

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Journal Year: 2024, Volume and Issue: unknown, P. 159589 - 159589

Published: Dec. 1, 2024

Language: Английский

Single nucleus RNA sequencing reveals cellular and molecular responses to vanadium exposure in duck kidneys DOI

Qiao Na,

Xueyan Dai, Jing Chen

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 480, P. 136492 - 136492

Published: Nov. 13, 2024

Language: Английский

Citations

11
Ginkgo biloba extract alleviates deltamethrin-induced testicular injury by upregulating SKP2 and inhibiting Beclin1-independent autophagy DOI
Huating Wang, Fan Yang,

J.D. Ye

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 135, P. 156245 - 156245

Published: Nov. 9, 2024

Language: Английский

Citations

7
Palliative potential of genistein to counteract endosulfan instigated colon toxicity via regulating TLR4/MyD88, JAK1/STAT3 and NF-κB pathway: A biochemical and histological approach DOI
Khalid J. Alzahrani,

Mahmoud El Safadi,

Khalaf F. Alsharif

et al.

Tissue and Cell, Journal Year: 2025, Volume and Issue: 93, P. 102730 - 102730

Published: Jan. 10, 2025

Language: Английский

Citations

0
Based on the Sam50-MICOS-ATAD3-mtDNA axis: Exploring oligomeric proanthocyanidins to alleviate molybdenum and cadmium co-induced liver inflammation in sheep DOI

Maokang Liu,

Junhua Ye, Fan Yang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141035 - 141035

Published: Feb. 1, 2025

Language: Английский

Citations

0
New insights into ovarian regression-related mitochondrial dysfunction in the late-laying period DOI Creative Commons
Tiantian Gu, Jinyu Liu, Tao Zeng

et al.

Poultry Science, Journal Year: 2025, Volume and Issue: 104(4), P. 104938 - 104938

Published: Feb. 22, 2025

Language: Английский

Citations

0
Pollutants in Microenvironmental Cellular Interactions During Liver Inflammation Cancer Transition and the Application of Multi-Omics Analysis DOI Creative Commons
Yulun Jian, Yuhan Li, Yanfeng Zhou

et al.

Toxics, Journal Year: 2025, Volume and Issue: 13(3), P. 163 - 163

Published: Feb. 25, 2025

This study categorizes pollutant-induced inflammation–cancer transition into three stages: non-alcoholic fatty liver disease (NAFLD), fibrosis, and hepatocellular carcinoma (HCC). It systematically reveals the temporal heterogeneity of damage. The findings indicate that pollutants not only directly damage hepatocytes but also modulate key cells in immune microenvironment, such as hepatic stellate (HSCs) Kupffer cells, thereby amplifying inflammatory fibrotic responses, ultimately accelerating progression HCC. Mechanistically, early stage primarily cause hepatocyte injury through oxidative stress lipid metabolism dysregulation. During fibrosis stage, promote by inducing extracellular matrix accumulation, while HCC they drive tumorigenesis via activation Wnt/β-catenin pathway p53 inactivation. Through multi-omics analyses, this identifies critical pathogenic molecules signaling pathways regulated pollutants, providing new insights their mechanisms, potential biomarkers, therapeutic targets. These offer valuable guidance for development diagnostic strategies diseases formulation environmental health risk prevention measures.

Language: Английский

Citations

0
UBA52 Mediates ribosomal DNA stability under hexavalent chromium exposure in occupational workers and cellular models DOI Creative Commons
Huadong Xu, Fan Wu,

Chuyan Zhang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 293, P. 118047 - 118047

Published: March 1, 2025

Language: Английский

Citations

0
Ochratoxin A-induced mitochondrial pathway apoptosis and ferroptosis by promoting glycolysis DOI
Yao Zhou, Wen‐Ying Chen, Shiyu Feng

et al.

APOPTOSIS, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Quercetin protects cadmium-induced kidney injury by regulating PI3K/AKT/mTOR and Nrf2/NQO1 pathways in rats DOI

Ruxue Huang,

Lulu Ding,

Wenjing Yu

et al.

Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 128, P. 106808 - 106808

Published: April 8, 2025

Language: Английский

Citations

0
Visual indicator for the detection of methylmercury in blood: A critical biomarker for dietary exposure assessment DOI Creative Commons
Yan Guo, Bing-chan Ma, Wen‐Qi Zhang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 295, P. 118157 - 118157

Published: April 1, 2025

Methylmercury (MeHg), a significant dietary exposure biomarker, poses substantial threat to public health, primarily due the consumption of aquatic foods. Current detection methods are complex and unsuitable for on-site testing, necessitating development simple sensitive biosensor rapid screening. This study addresses this challenge by developing highly whole-cell detecting organic mercury in blood samples, offering both visual qualitative colorimetric quantitative assessments. We engineered based on mer operon deoxyviolacein (DV) pigment, optimizing its performance adjusting MerB expression level, screening host cells, incorporating biosurfactant rhamnolipid. The optimized achieved limit 0.195 nM exhibited linear response range 0.195-1.563 MeHg. is significantly below Provisional Tolerable Weekly Intake (PTWI) 1.6 μg/kg body weight per week established Joint FAO/WHO Expert Committee Food Additives (JECFA), ensuring reliable MeHg at concentrations well within safety threshold. Notably, demonstrated broad-spectrum capabilities, including natural synthetic organomercurials, which crucial assessing risks from various sources. advances novel detection, highlighting potential as critical tool contributing understanding food health.

Language: Английский

Citations

0