Mechanisms of NAFLD development and therapeutic strategies

Nature Medicine, Год журнала: 2018, Номер 24(7), С. 908 - 922

Опубликована: Июнь 29, 2018

Язык: Английский

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Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues

Molecular Aspects of Medicine, Год журнала: 2018, Номер 65, С. 37 - 55

Опубликована: Сен. 13, 2018

Язык: Английский

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Non-alcoholic fatty liver disease: causes, diagnosis, cardiometabolic consequences, and treatment strategies

The Lancet Diabetes & Endocrinology, Год журнала: 2018, Номер 7(4), С. 313 - 324

Опубликована: Авг. 30, 2018

Язык: Английский

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Role of Oxidative Stress in Pathophysiology of Nonalcoholic Fatty Liver Disease

Oxidative Medicine and Cellular Longevity, Год журнала: 2018, Номер 2018, С. 1 - 14

Опубликована: Янв. 1, 2018

Liver steatosis without alcohol consumption, namely, nonalcoholic fatty liver disease (NAFLD), is a common hepatic condition that encompasses wide spectrum of presentations, ranging from simple accumulation triglycerides in the hepatocytes any damage to inflammation, necrosis, ballooning, and fibrosis (namely, steatohepatitis) up severe eventually cirrhosis and/or hepatocellular carcinoma. The pathophysiology its progression influenced by multiple factors (environmental genetics), “multiple parallel-hit model,” which oxidative stress plays very likely primary role as starting point extrahepatic damage. aim this review give comprehensive insight on present researches findings mechanisms pathogenesis NAFLD. With aim, we evaluated available data basic science clinical studies field, reviewing most recent works published topic.

Язык: Английский

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The Intricate Relationship between Type 2 Diabetes Mellitus (T2DM), Insulin Resistance (IR), and Nonalcoholic Fatty Liver Disease (NAFLD)

Journal of Diabetes Research, Год журнала: 2020, Номер 2020, С. 1 - 16

Опубликована: Авг. 4, 2020

Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) remain as one of the most global problematic metabolic diseases with rapidly increasing prevalence incidence. Epidemiological studies noted that T2DM patients have by two-fold increase to develop NAFLD, vice versa. This complex intricate association is supported mediated insulin resistance (IR). In this review, we discuss NAFLD immunopathogenesis, connection IR T2DM, role screening noninvasive tools, mostly impact current antidiabetic drugs on steatosis new potential therapeutic targets.

Язык: Английский

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Determinants of fibrosis progression and regression in NASH

Journal of Hepatology, Год журнала: 2017, Номер 68(2), С. 238 - 250

Опубликована: Ноя. 14, 2017

Язык: Английский

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Global pandemics interconnected — obesity, impaired metabolic health and COVID-19

Nature Reviews Endocrinology, Год журнала: 2021, Номер 17(3), С. 135 - 149

Опубликована: Янв. 21, 2021

Obesity and impaired metabolic health are established risk factors for the non-communicable diseases (NCDs) type 2 diabetes mellitus, cardiovascular disease, neurodegenerative diseases, cancer nonalcoholic fatty liver otherwise known as associated disease (MAFLD). With worldwide spread of severe acute respiratory syndrome coronavirus (SARS-CoV-2), obesity also emerged important determinants 2019 (COVID-19). Furthermore, novel findings indicate that specifically visceral characteristics such hyperglycaemia, hypertension subclinical inflammation with a high COVID-19. In this Review, we highlight how increase complications mortality in We summarize consequences SARS-CoV-2 infection organ function NCDs. addition, discuss data indicating COVID-19 pandemic could have serious epidemic. As both accelerators COVID-19, might adversely influence efficacy vaccines, propose strategies prevention treatment on clinical population level, particularly while is present. This Review highlights (COVID-19) summarizes function. there discussion implications pandemic.

Язык: Английский

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A global view of the interplay between non-alcoholic fatty liver disease and diabetes

The Lancet Diabetes & Endocrinology, Год журнала: 2022, Номер 10(4), С. 284 - 296

Опубликована: Фев. 17, 2022

Язык: Английский

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Nonalcoholic Fatty Liver Disease: Basic Pathogenetic Mechanisms in the Progression From NAFLD to NASH

Transplantation, Год журнала: 2018, Номер 103(1), С. e1 - e13

Опубликована: Окт. 9, 2018

Nonalcoholic fatty liver disease (NAFLD) represents a growing cause of chronic injury, especially in western countries, where it is becoming the most frequent indication for transplantation. encompasses spectrum diseases that from simple steatosis (pure NAFLD) can progress to nonalcoholic steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma. The pathogenesis NAFLD mechanisms behind its progression NASH have been extensively studied. However, although processes determine fat accumulation are mostly clear, associated with not fully characterized. In predisposed patients, lipid promote lipotoxicity mitochondrial dysfunction, thus triggering hepatocyte death, inflammation fibrosis. specific role different lipids has identified free acids as well cholesterol toxic species. To make picture more complex, involves pathological connections between several organs, including adipose tissue gut, liver. "inflamed" plays key release lipids, whereas alterations gut-liver axis mediated by dysbiosis, alteration intestinal barrier, finally bacterial translocation, which trigger proinflammatory profibrogenetic pathways, leading development.

Язык: Английский

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Emerging therapeutic approaches for the treatment of NAFLD and type 2 diabetes mellitus

Nature Reviews Endocrinology, Год журнала: 2021, Номер 17(8), С. 484 - 495

Опубликована: Июнь 15, 2021

Язык: Английский

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