Mechanisms of NAFLD development and therapeutic strategies

Nature Medicine, Journal Year: 2018, Volume and Issue: 24(7), P. 908 - 922

Published: June 29, 2018

Language: Английский

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Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues

Molecular Aspects of Medicine, Journal Year: 2018, Volume and Issue: 65, P. 37 - 55

Published: Sept. 13, 2018

Language: Английский

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Non-alcoholic fatty liver disease: causes, diagnosis, cardiometabolic consequences, and treatment strategies

The Lancet Diabetes & Endocrinology, Journal Year: 2018, Volume and Issue: 7(4), P. 313 - 324

Published: Aug. 30, 2018

Language: Английский

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Role of Oxidative Stress in Pathophysiology of Nonalcoholic Fatty Liver Disease

Oxidative Medicine and Cellular Longevity, Journal Year: 2018, Volume and Issue: 2018, P. 1 - 14

Published: Jan. 1, 2018

Liver steatosis without alcohol consumption, namely, nonalcoholic fatty liver disease (NAFLD), is a common hepatic condition that encompasses wide spectrum of presentations, ranging from simple accumulation triglycerides in the hepatocytes any damage to inflammation, necrosis, ballooning, and fibrosis (namely, steatohepatitis) up severe eventually cirrhosis and/or hepatocellular carcinoma. The pathophysiology its progression influenced by multiple factors (environmental genetics), “multiple parallel-hit model,” which oxidative stress plays very likely primary role as starting point extrahepatic damage. aim this review give comprehensive insight on present researches findings mechanisms pathogenesis NAFLD. With aim, we evaluated available data basic science clinical studies field, reviewing most recent works published topic.

Language: Английский

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The Intricate Relationship between Type 2 Diabetes Mellitus (T2DM), Insulin Resistance (IR), and Nonalcoholic Fatty Liver Disease (NAFLD)

Journal of Diabetes Research, Journal Year: 2020, Volume and Issue: 2020, P. 1 - 16

Published: Aug. 4, 2020

Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) remain as one of the most global problematic metabolic diseases with rapidly increasing prevalence incidence. Epidemiological studies noted that T2DM patients have by two-fold increase to develop NAFLD, vice versa. This complex intricate association is supported mediated insulin resistance (IR). In this review, we discuss NAFLD immunopathogenesis, connection IR T2DM, role screening noninvasive tools, mostly impact current antidiabetic drugs on steatosis new potential therapeutic targets.

Language: Английский

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Determinants of fibrosis progression and regression in NASH

Journal of Hepatology, Journal Year: 2017, Volume and Issue: 68(2), P. 238 - 250

Published: Nov. 14, 2017

Language: Английский

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Global pandemics interconnected — obesity, impaired metabolic health and COVID-19

Nature Reviews Endocrinology, Journal Year: 2021, Volume and Issue: 17(3), P. 135 - 149

Published: Jan. 21, 2021

Obesity and impaired metabolic health are established risk factors for the non-communicable diseases (NCDs) type 2 diabetes mellitus, cardiovascular disease, neurodegenerative diseases, cancer nonalcoholic fatty liver otherwise known as associated disease (MAFLD). With worldwide spread of severe acute respiratory syndrome coronavirus (SARS-CoV-2), obesity also emerged important determinants 2019 (COVID-19). Furthermore, novel findings indicate that specifically visceral characteristics such hyperglycaemia, hypertension subclinical inflammation with a high COVID-19. In this Review, we highlight how increase complications mortality in We summarize consequences SARS-CoV-2 infection organ function NCDs. addition, discuss data indicating COVID-19 pandemic could have serious epidemic. As both accelerators COVID-19, might adversely influence efficacy vaccines, propose strategies prevention treatment on clinical population level, particularly while is present. This Review highlights (COVID-19) summarizes function. there discussion implications pandemic.

Language: Английский

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A global view of the interplay between non-alcoholic fatty liver disease and diabetes

The Lancet Diabetes & Endocrinology, Journal Year: 2022, Volume and Issue: 10(4), P. 284 - 296

Published: Feb. 17, 2022

Language: Английский

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Nonalcoholic Fatty Liver Disease: Basic Pathogenetic Mechanisms in the Progression From NAFLD to NASH

Transplantation, Journal Year: 2018, Volume and Issue: 103(1), P. e1 - e13

Published: Oct. 9, 2018

Nonalcoholic fatty liver disease (NAFLD) represents a growing cause of chronic injury, especially in western countries, where it is becoming the most frequent indication for transplantation. encompasses spectrum diseases that from simple steatosis (pure NAFLD) can progress to nonalcoholic steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma. The pathogenesis NAFLD mechanisms behind its progression NASH have been extensively studied. However, although processes determine fat accumulation are mostly clear, associated with not fully characterized. In predisposed patients, lipid promote lipotoxicity mitochondrial dysfunction, thus triggering hepatocyte death, inflammation fibrosis. specific role different lipids has identified free acids as well cholesterol toxic species. To make picture more complex, involves pathological connections between several organs, including adipose tissue gut, liver. "inflamed" plays key release lipids, whereas alterations gut-liver axis mediated by dysbiosis, alteration intestinal barrier, finally bacterial translocation, which trigger proinflammatory profibrogenetic pathways, leading development.

Language: Английский

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Emerging therapeutic approaches for the treatment of NAFLD and type 2 diabetes mellitus

Nature Reviews Endocrinology, Journal Year: 2021, Volume and Issue: 17(8), P. 484 - 495

Published: June 15, 2021

Language: Английский

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