Nature Metabolism, Год журнала: 2021, Номер 3(12), С. 1596 - 1607
Опубликована: Дек. 20, 2021
Язык: Английский
The Lancet, Год журнала: 2021, Номер 397(10290), С. 2212 - 2224
Опубликована: Апрель 21, 2021
Язык: Английский
Процитировано
1878
Journal of Hepatology, Год журнала: 2023, Номер 79(6), С. 1542 - 1556
Опубликована: Июнь 24, 2023
The principal limitations of the terms NAFLD and NASH are reliance on exclusionary confounder use potentially stigmatising language. This study set out to determine if content experts patient advocates were in favour a change nomenclature and/or definition. A modified Delphi process was led by three large pan-national liver associations. consensus defined priori as supermajority (67%) vote. An independent committee external made final recommendation acronym its diagnostic criteria. total 236 panellists from 56 countries participated 4 online surveys 2 hybrid meetings. Response rates across survey rounds 87%, 83%, 78%, respectively. Seventy-four percent respondents felt that current sufficiently flawed consider name change. "nonalcoholic" "fatty" be 61% 66% respondents, Steatotic disease chosen an overarching term encompass various aetiologies steatosis. steatohepatitis important pathophysiological concept should retained. replace metabolic dysfunction-associated steatotic (MASLD). There definition include presence at least 1 5 cardiometabolic risk factors. Those with no parameters known cause deemed have cryptogenic disease. new category, outside pure disease, termed alcohol related/associated (MetALD), selected describe those who consume greater amounts per week (140-350 g/wk 210-420 for females males, respectively). criteria widely supported non-stigmatising, can improve awareness identification.
Язык: Английский
Процитировано
1428
Hepatology, Год журнала: 2023, Номер 78(6), С. 1966 - 1986
Опубликована: Июнь 22, 2023
The principal limitations of the terms NAFLD and NASH are reliance on exclusionary confounder use potentially stigmatising language. This study set out to determine if content experts patient advocates were in favor a change nomenclature and/or definition. A modified Delphi process was led by three large pan-national liver associations. consensus defined priori as supermajority (67%) vote. An independent committee external made final recommendation acronym its diagnostic criteria. total 236 panelists from 56 countries participated 4 online surveys 2 hybrid meetings. Response rates across survey rounds 87%, 83%, 78%, respectively. Seventy-four percent respondents felt that current sufficiently flawed consider name change. “nonalcoholic” “fatty” be 61% 66% respondents, Steatotic disease chosen an overarching term encompass various aetiologies steatosis. steatohepatitis important pathophysiological concept should retained. replace metabolic dysfunction–associated steatotic disease. There definition include presence at least 1 5 cardiometabolic risk factors. Those with no parameters known cause deemed have cryptogenic new category, outside pure disease, termed alcohol related/associated (MetALD), selected describe those who consume greater amounts per week (140–350 g/wk 210–420 for females males, respectively). criteria widely supported nonstigmatising, can improve awareness identification.
Язык: Английский
Процитировано
1268
Hepatology International, Год журнала: 2020, Номер 14(6), С. 889 - 919
Опубликована: Окт. 1, 2020
Язык: Английский
Процитировано
652
The Lancet, Год журнала: 2022, Номер 400(10365), С. 1803 - 1820
Опубликована: Ноя. 1, 2022
Язык: Английский
Процитировано
587
Nature Reviews Gastroenterology & Hepatology, Год журнала: 2021, Номер 18(9), С. 599 - 612
Опубликована: Май 10, 2021
Язык: Английский
Процитировано
586
Annals of Hepatology, Год журнала: 2023, Номер 29(1), С. 101133 - 101133
Опубликована: Июнь 24, 2023
The principal limitations of the terms NAFLD and NASH are reliance on exclusionary confounder use potentially stigmatising language. This study set out to determine if content experts patient advocates were in favor a change nomenclature and/or definition. A modified Delphi process was led by three large pan-national liver associations. consensus defined priori as supermajority (67%) vote. An independent committee external made final recommendation acronym its diagnostic criteria. total 236 panelists from 56 countries participated 4 online surveys 2 hybrid meetings. Response rates across survey rounds 87%, 83%, 78%, respectively. Seventy-four percent respondents felt that current sufficiently flawed consider name change. "nonalcoholic" "fatty" be 61% 66% respondents, Steatotic disease chosen an overarching term encompass various aetiologies steatosis. steatohepatitis important pathophysiological concept should retained. replace metabolic dysfunction-associated steatotic disease. There definition include presence at least 1 5 cardiometabolic risk factors. Those with no parameters known cause deemed have cryptogenic new category, outside pure disease, termed alcohol related/associated (MetALD), selected describe those who consume greater amounts per week (140-350 g/wk 210-420 for females males, respectively). criteria widely supported nonstigmatising, can improve awareness identification.
Язык: Английский
Процитировано
559
Nature Reviews Gastroenterology & Hepatology, Год журнала: 2021, Номер 19(1), С. 60 - 78
Опубликована: Окт. 27, 2021
Язык: Английский
Процитировано
535
Diabetology & Metabolic Syndrome, Год журнала: 2020, Номер 12(1)
Опубликована: Июль 14, 2020
Abstract Background The prevalence of non-alcoholic fatty liver disease (NAFLD) has been increasing rapidly. It is nowadays recognized as the most frequent disease, affecting a quarter global population and regularly coexisting with metabolic disorders such type 2 diabetes, hypertension, obesity, cardiovascular disease. In more simplistic view, NAFLD could be defined an increase in fat content, absence secondary cause steatosis. fact, clinical onset much complex process, closely related to insulin resistance, limited expandability dysfunctionality adipose tissue. A main driver for new liver-pancreatic α-cell axis increased glucagon, contributing diabetes pathophysiology. Main text This review will focus on pathophysiological connections between NAFLD, resistance diabetes. We reviewed non-invasive methods several scoring systems estimative steatosis fibrosis, proposing multistep process evaluation. also discuss treatment options comprehensive focusing current available therapies obesity and/or that impact each stage NAFLD. Conclusion proper understanding spectrum—as continuum from syndrome diabetes—may contribute early identification establishment targeted treatment.
Язык: Английский
Процитировано
483
Liver International, Год журнала: 2020, Номер 40(9), С. 2082 - 2089
Опубликована: Июнь 1, 2020
Abstract Background and aims Metabolic associated fatty liver disease (MAFLD) is a novel concept proposed in 2020, the utility of which has not been tested validated real world. We aimed to compare characteristics MAFLD non‐alcoholic (NAFLD). Methods The data was retrieved from third National Health Nutrition Examination Surveys United States, an unbiased survey dataset frequently used for study disease. Results A total 13 083 cases with completed ultrasonography laboratory were identified NHANES III database. diagnosed 4087/13 (31.24%) participants, while NAFLD 4347/13 (33.23%) amongst overall population 4347/12 045 (36.09%) patients without alcohol intake other diseases. Compared NAFLD, significantly older, had higher BMI level, proportions metabolic comorbidities (diabetes, hypertension) HOMA‐IR, lipid enzymes. consumption younger than those without, more likely be male. They less disorder but There advance fibrosis consumption. Conclusion definition practical identifying high risk progression.
Язык: Английский
Процитировано
480