Defining paediatric metabolic (dysfunction)-associated fatty liver disease: an international expert consensus statement

˜The œLancet. Gastroenterology & hepatology, Год журнала: 2021, Номер 6(10), С. 864 - 873

Опубликована: Авг. 6, 2021

Язык: Английский

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The EASL–Lancet Liver Commission: protecting the next generation of Europeans against liver disease complications and premature mortality

The Lancet, Год журнала: 2021, Номер 399(10319), С. 61 - 116

Опубликована: Дек. 2, 2021

Язык: Английский

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Intestinal Barrier and Permeability in Health, Obesity and NAFLD

Biomedicines, Год журнала: 2021, Номер 10(1), С. 83 - 83

Опубликована: Дек. 31, 2021

The largest surface of the human body exposed to external environment is gut. At this level, intestinal barrier includes luminal microbes, mucin layer, gastrointestinal motility and secretion, enterocytes, immune cells, gut vascular barrier, liver barrier. A healthy characterized by selective permeability nutrients, metabolites, water, bacterial products, processes are governed cellular, neural, immune, hormonal factors. Disrupted (leaky syndrome) can represent a predisposing or aggravating condition in obesity metabolically associated steatosis (nonalcoholic fatty disease, NAFLD). In what follows, we describe morphological-functional features role major modifiers discuss recent evidence pointing key obesity/NAFLD.

Язык: Английский

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An international Delphi consensus statement on metabolic dysfunction-associated fatty liver disease and risk of chronic kidney disease

HepatoBiliary Surgery and Nutrition, Год журнала: 2023, Номер 12(3), С. 386 - 403

Опубликована: Фев. 24, 2023

With the rising global prevalence of fatty liver disease related to metabolic dysfunction, association this common condition with chronic kidney (CKD) has become increasingly evident. In 2020, more inclusive term dysfunction-associated (MAFLD) was proposed replace non-alcoholic (NAFLD). The observed between MAFLD and CKD our understanding that can be a consequence underlying dysfunction support notion individuals are at higher risk having developing compared those without MAFLD. However, date, there is no appropriate guidance on in Furthermore, been little attention paid link Nephrology community.Using Delphi-based approach, multidisciplinary panel 50 international experts from 26 countries reached consensus some open research questions regarding CKD.This statement provided epidemiology, mechanisms, management treatment CKD, as well relationship severity which establish framework for early prevention these two interconnected diseases.

Язык: Английский

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Natural History of Metabolic Dysfunction-Associated Steatotic Liver Disease: From Metabolic Syndrome to Hepatocellular Carcinoma

Medicina, Год журнала: 2025, Номер 61(1), С. 88 - 88

Опубликована: Янв. 7, 2025

Introduction: Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) stems from disrupted lipid metabolism in the liver, often linked to obesity, type 2 diabetes, and dyslipidemia. In Mexico, where obesity affects 36.9% of adults, MASLD prevalence has risen, especially with metabolic syndrome affecting 56.31% by 2018. can progress Steatohepatitis (MASH), 5.27% globally, leading severe complications like cirrhosis hepatocellular carcinoma. Background: Visceral fat distribution varies gender, impacting development due hormonal influences. Insulin resistance plays a central role pathogenesis, exacerbated high-fat diets specific fatty acids, hepatic steatosis. Lipotoxicity saturated acids further damages hepatocytes, triggering inflammation fibrosis progression MASH. Diagnosing traditionally involves invasive liver biopsy, but non-invasive methods ultrasound transient elastography are preferred their safety availability. These detect steatosis reasonable accuracy, offering alternatives biopsy despite varying sensitivity specificity. Conclusions: as disorder underscores its impact on public health, necessitating improved awareness early management strategies mitigate diseases.

Язык: Английский

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MAFLD: Renovation of clinical practice and disease awareness of fatty liver

Hepatology Research, Год журнала: 2021, Номер 52(5), С. 422 - 432

Опубликована: Сен. 2, 2021

Recently, international expert panels have proposed a new definition of fatty liver: metabolic dysfunction-associated liver disease (MAFLD). MAFLD is not just simple renaming non-alcoholic (NAFLD). The unique feature the inclusion dysfunctions, which are high-risk factors for events. In addition, independent alcohol intake and co-existing causes disease. This concept may widespread impact on patients, medical doctors, staff, various stakeholders regarding liver. Thus, renovate clinical practice awareness this review, we introduce rationale MAFLD. We further describe representative cases showing how diagnostic processes differ between NAFLD. also summarize recent studies comparing with NAFLD discuss trials, Japanese populations, awareness.

Язык: Английский

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Lower Serologic Response to COVID-19 mRNA Vaccine in Patients With Inflammatory Bowel Diseases Treated With Anti-TNFα

Gastroenterology, Год журнала: 2021, Номер 162(2), С. 454 - 467

Опубликована: Окт. 28, 2021

Patients with inflammatory bowel diseases (IBD), specifically those treated anti-tumor necrosis factor (TNF)α biologics, are at high risk for vaccine-preventable infections. Their ability to mount adequate vaccine responses is unclear. The aim of the study was assess serologic messenger RNA-Coronavirus Disease 2019 vaccine, and safety profile, in patients IBD stratified according therapy, compared healthy controls (HCs).Prospective, controlled, multicenter Israeli study. Subjects enrolled received 2 BNT162b2 (Pfizer/BioNTech) doses. Anti-spike antibody levels functional activity, anti-TNFα adverse events (AEs) were detected longitudinally.Overall, 258 subjects: 185 (67 anti-TNFα, 118 non-anti-TNFα), 73 HCs. After first dose, all HCs seropositive, whereas ∼7% IBD, regardless treatment, remained seronegative. second subjects however anti-spike significantly lower non-anti-TNFα patients, (both P < .001). Neutralizing inhibitory functions both (P .03; .0001, respectively). Anti-TNFα drug did not affect levels. Infection rate (∼2%) AEs comparable groups. activity unaffected by BNT162b2.In this prospective mounted response doses BNT162b2; however, its magnitude administration timing Vaccine safe. As longevity group may be limited, booster dose should considered.

Язык: Английский

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MAFLD enhances clinical practice for liver disease in the Asia-Pacific region

Clinical and Molecular Hepatology, Год журнала: 2021, Номер 28(2), С. 150 - 163

Опубликована: Ноя. 10, 2021

Fatty liver is now a major cause of disease in the Asia-Pacific region. Liver diseases this region have distinctive characteristics. First, fatty frequently observed lean/normal-weight individuals. However, there no standard definition unique phenotype. Second, often patients with concomitant viral hepatitis. The exclusion hepatitis from non-alcoholic limits its value and detracts investigation holistic management coexisting Third, liver-associated hepatocellular carcinoma (HCC) generally categorized as non-B non-C HCC. Fourth, population aging rapidly, it imperative to develop practicable, low-intensity exercise program for elderly patients. Fifth, most nonspecialized healthcare professionals still lack an awareness significance both terms intrahepatic extrahepatic cancer. Recently, international expert panel proposed new liver: metabolic dysfunction-associated (MAFLD). One feature MAFLD that dysfunction prerequisite diagnosis. Pertinent regional issues, also provides diagnostic criteria Furthermore, independent any disease, including Therefore, may be more suitable In review, we introduce characteristics discuss advantages improving clinical practice

Язык: Английский

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Metabolic dysfunction-associated fatty liver disease: a year in review

Current Opinion in Gastroenterology, Год журнала: 2022, Номер 38(3), С. 251 - 260

Опубликована: Фев. 9, 2022

Purpose of review In 2020, a novel comprehensive redefinition fatty liver disease was proposed by an international panel experts. This aims to explore current evidence regarding the impact this new definition on understanding epidemiology, pathogenesis, diagnosis, and clinical trials for disease. Recent findings The effectiveness metabolic dysfunction-associated (MAFLD) compared existing criteria nonalcoholic (NAFLD). data robustly suggest superior utility MAFLD in identifying patients at high risk dysfunction, hepatic extra-hepatic complications, as well those who would benefit from genetic testing, including with concomitant diseases. change name also appears have improved awareness among physicians. Summary transformation NAFLD represents important milestone, which indicates significant tangible progress towards more inclusive, equitable, patient-centred approach addressing profound challenges Growing has illustrated broader specific contexts that tremendous potential positively influencing diagnosis treatment. addition, momentum accompanying included widespread public attention unique burden previously underappreciated

Язык: Английский

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NAFLD, MAFLD, and beyond: one or several acronyms for better comprehension and patient care

Internal and Emergency Medicine, Год журнала: 2023, Номер 18(4), С. 993 - 1006

Опубликована: Фев. 17, 2023

Abstract The term non-alcoholic fatty liver disease (NAFLD) has rapidly become the most common type of chronic disease. NAFLD points to excessive hepatic fat storage and no evidence secondary accumulation in patients with “no or little alcohol consumption”. Both etiology pathogenesis are largely unknown, a definitive therapy is lacking. Since very often closely associated metabolic dysfunctions, consensus process ongoing shift acronym MAFLD, i.e., metabolic-associated change terminology likely improve classification affected individuals, awareness, comprehension pathophysiological aspects involved, choice more personalized therapeutic approaches while avoiding intrinsic stigmatization due “non-alcoholic”. Even recently, other sub-classifications have been proposed concentrate heterogeneous causes under one umbrella. While awaiting additional validation studies this field, we discuss main reasons underlying important paradigm.

Язык: Английский

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