Frontiers in Nutrition, Год журнала: 2023, Номер 10
Опубликована: Фев. 22, 2023
Non-alcoholic fatty liver disease (NAFLD) is one of the most common causes chronic disease. Several epidemiological studies attempted to assess association between dairy product and likelihood NAFLD, but contribution consumption NAFLD remains controversial. We conducted a meta-analysis investigate NAFLD.
Язык: Английский
Clinical Gastroenterology and Hepatology, Год журнала: 2024, Номер 22(9), С. 1774 - 1789.e8
Опубликована: Апрель 10, 2024
Язык: Английский
Процитировано
10
Nature Communications, Год журнала: 2024, Номер 15(1)
Опубликована: Май 2, 2024
Abstract Nuclear magnetic resonance (NMR)-based plasma fatty acids are objective biomarkers of many diseases. Herein, we aim to explore the associations NMR-based with risk hepatocellular carcinoma (HCC) and chronic liver disease (CLD) mortality in 252,398 UK Biobank participants. Here show levels n-3 poly-unsaturated (PUFA) n-6 PUFA negatively associated incident HCC [HR Q4vsQ1 : 0.48 (95% CI: 0.33–0.69) 0.28–0.81), respectively] CLD 0.21 0.13–0.33) 0.15 0.08–0.30), respectively], whereas saturated positively these outcomes 3.55 2.25–5.61) for 6.34 3.68–10.92) mortality]. Furthermore, fibrosis stage significantly modifies between mortality. This study contributes limited prospective evidence on plasma-specific end-stage outcomes.
Язык: Английский
Процитировано
10
Cancer Communications, Год журнала: 2024, Номер 44(7), С. 718 - 738
Опубликована: Июнь 5, 2024
Abstract Background Benzo[a]pyrene (B[a]P), a carcinogen pollutant produced by combustion processes, is present in the western diet with grilled meats. Chronic exposure of B[a]P hepatocellular carcinoma (HCC) cells promotes metastasis rather than primary proliferation, implying an unknown mechanism B[a]P‐induced malignancy. Given that exosomes carry bioactive molecules to distant sites, we investigated whether and how mediate cancer‐stroma communications for toxicologically associated microenvironment. Method Exosomes were isolated from stimulated BEL7404 HCC (7404‐100Bap Exo) at environmental relevant dose (100 nmol/L). Lung pre‐education animal model was prepared via injection cytokines. The inflammatory genes educated lungs evaluated using quantitative reverse transcription PCR array. LM3 transfected firefly luciferase next injected monitor tumor burdens organotropic metastasis. Profile B[a]P‐exposed determined ceRNA microarray. Interactions between circular RNA (circRNA) microRNAs (miRNAs) detected pull‐down target lung fibroblasts. Fluorescence situ hybridization immunoprecipitation assay used evaluate “on‐off” interaction circRNA‐miRNA pairs. We further developed adeno‐associated virus inhalation examine mRNA expression specific lung, thereby exploring targets induced cascade. Results fibroblasts exert activation phenotypes, including focal adhesion motility altered 7404‐100Bap Exo. In exosome‐educated vivo model, fibrosis factors pro‐inflammatory are up‐regulated when exosomes. Compared non‐exposed 7404 cells, circ_0011496 following treatment mainly packaged into Exosomal delivered competitively bound miR‐486‐5p recipient down‐regulation converted fibroblast cancer‐associated regulating downstream Twinfilin‐1 (TWF1) matrix metalloproteinase‐9 (MMP9) Additionally, increased TWF1, specifically exosomal lungs, could promote crosstalk activating vascular endothelial growth factor (VEGF). These modulated promoted angiogenesis recruited invasion, as consequence pre‐metastatic niche formation. Conclusion demonstrated can deliver activate miR‐486‐5p/TWF1/MMP9 cascade fibroblasts, generating feedback loop
Язык: Английский
Процитировано
10
European Journal of Gastroenterology & Hepatology, Год журнала: 2023, Номер 35(4), С. 353 - 358
Опубликована: Янв. 31, 2023
Currently, nonalcoholic fatty liver disease (NAFLD) is the main cause of chronic and liver-related mortality worldwide. Hepatocellular carcinoma (HCC) a fatal complication in patients with NAFLD. However, whether statins can reduce risk HCC NAFLD remains controversial. We aimed to determine relationship between statin use occurrence among independently retrieved related studies from PubMed, EMBASE, Cochrane Library, Web Science, ClinicalTrial.gov (from 1 January 2000 27 February 2022). The outcome was development HCC. A fixed-effects model used merge odds ratio (OR) meta-analysis. Five involving 684 363 were included. results meta-analysis suggested significantly lower users [OR = 0.59; 95% confidence interval (CI), 0.39–0.89; I 2 87.90%]. Additionally, observed aged less than 65 years (OR CI, 0.46–0.77; 20.50%). Statins
Язык: Английский
Процитировано
20
Cancers, Год журнала: 2023, Номер 15(22), С. 5458 - 5458
Опубликована: Ноя. 17, 2023
Non-alcoholic fatty liver disease (NAFLD) affects up to a quarter of the adult population in many developed and developing countries. This spectrum ranges from simple steatosis non-alcoholic steatohepatitis (NASH) cirrhosis. The incidence NASH is projected increase by 56% over next 10 years. There growing epidemiological evidence that NAFLD has become fastest-growing cause hepatocellular carcinoma (HCC) industrialized annual HCC varies between patients with cirrhosis noncirrhotic NAFLD. In this review, NAFLD/NASH-associated will be described, including its epidemiology, risk factors promoting hepatocarcinogenesis, management obesity associated metabolic comorbidities, preventive strategies therapeutic approaches address problem.
Язык: Английский
Процитировано
20
World Journal of Gastroenterology, Год журнала: 2024, Номер 30(7), С. 652 - 662
Опубликована: Фев. 21, 2024
Metabolic dysfunction-associated steatotic liver disease (MASLD) affects approximately 25% of the world's population and has become a leading cause chronic disease. In recent years, an increasing amount data suggests that MASLD is associated with aging. As ages, age-related will major global health problem. Targeting aging new approach to treatment MASLD. This paper reviews current studies on role aging-related factors therapeutic targets in MASLD, including: Oxidative stress, autophagy, mitochondrial homeostasis, bile acid metabolism dysbiosis. The aim identify effective for its progression.
Язык: Английский
Процитировано
8
Bioorganic Chemistry, Год журнала: 2024, Номер 150, С. 107539 - 107539
Опубликована: Июнь 8, 2024
Язык: Английский
Процитировано
8
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Фев. 1, 2024
Hepatocellular carcinoma (HCC) is one of the most prevalent cancers worldwide and accounts for more than 90% primary liver cancer. The advent immune checkpoint inhibitor (ICI)-related therapies combined with angiogenesis inhibition has revolutionized treatment HCC in late-stage unresectable HCC, as ICIs alone were disappointing treating HCC. In addition to altered microenvironment, abnormal lipid metabolism been extensively characterized various types Stains are known their cholesterol-lowering properties long history hypercholesterolemia reducing cardiovascular disease risk. Apart from ICI other conventional therapies, statins frequently used by advanced patients dyslipidemia, which often marked accumulation cholesterol fatty acids liver. Supported a body preclinical clinical studies, may unexpectedly enhance efficacy therapy through regulation inflammatory responses microenvironment. This review discusses changes summarizes evidence benefits stain use prospects possible mechanistic actions transforming microenvironment when immunotherapies. Consequently, statin emerge novel valuable adjuvant immunotherapies
Язык: Английский
Процитировано
7
Alimentary Pharmacology & Therapeutics, Год журнала: 2024, Номер unknown
Опубликована: Сен. 20, 2024
Summary Background The new nomenclature of metabolic dysfunction‐associated steatotic liver disease (MASLD) substituting nonalcoholic fatty was proposed along with a category MASLD increased alcohol intake (MetALD). Aims We aimed to explore the cancer risk by and MetALD. Methods This nationwide cohort study included 3,596,709 participants who underwent health check‐up in 2011 South Korea. Steatotic (SLD) defined as index ≥30. Participants were categorized into four exclusive groups: MASLD, MetALD, other combination aetiology no SLD. subdistribution hazard ratio (SHR) calculated using Fine–Gray model after adjusting variables. Results During 33.9 million person‐years follow‐up, 285,845 (7.9%) developed cancers. Compared SLD, MetALD had an all cancer. Liver escalated from SLD (SHR, 1.16; 95% CI, 1.12–1.21), 2.06; 1.92–2.20) 8.16; 7.69–8.67). Gastrointestinal cancers including oesophagus, stomach, colorectal, biliary pancreas 1.13; 1.11–1.15), 1.17; 1.14–1.21) 1.09; 1.05–1.13). A modest increase lung hormone‐sensitive observed MASLD. Conclusions showed that are associated cancer, particularly gastrointestinal findings build evidence for clinical outcomes while highlighting importance managing properly
Язык: Английский
Процитировано
7
Journal of Hepatocellular Carcinoma, Год журнала: 2022, Номер Volume 9, С. 477 - 496
Опубликована: Июнь 1, 2022
Abstract: Obesity has been labeled as the global pandemic of 21st century, resulting from a sedentary lifestyle and caloric excess. Nonalcoholic fatty liver disease (NAFLD), characterized by excessive hepatic steatosis, is strongly associated with obesity metabolic syndrome estimated to be present in one-quarter world population, making it most common cause chronic (CLD). NAFLD spectrum varies simple steatosis nonalcoholic steatohepatitis (NASH) cirrhosis. The burden predicted increase coming decades increased rates decompensated cirrhosis, hepatocellular carcinoma (HCC), liver-related deaths. In current review, we describe pathophysiology NASH, risk factors progression, related complications, mortality. Later, have discussed changing epidemiology HCC, emerging CLD HCC. We also addressed HCC development population (including demographic, metabolic, genetic, dietary, factors), presentation NAFLD-associated its prognosis, issue non-cirrhotic NAFLD. Lastly, problems screening remaining challenges, future directions, especially need identify high-risk individuals, will discussed. conclude review summarizing clinical evidence for treating fibrosis preventing those at Keywords: disease, steatohepatitis, carcinoma, syndrome,
Язык: Английский
Процитировано
28