Cancers,
Год журнала:
2022,
Номер
14(13), С. 3059 - 3059
Опубликована: Июнь 22, 2022
SLC7A11
controls
the
uptake
of
extracellular
cystine
in
exchange
for
glutamate
at
a
ratio
1:1,
and
it
is
overexpressed
variety
tumours.
Accumulating
evidence
has
shown
that
expression
fine-tuned
multiple
levels,
plays
diverse
functional
pharmacological
roles
tumours,
such
as
cellular
redox
homeostasis,
cell
growth
death,
metabolism.
Many
reports
have
suggested
inhibition
activity
favourable
tumour
therapy;
thus,
regarded
potential
therapeutic
target.
However,
emerging
also
suggests
on
some
occasions,
beneficial
to
survival
cancer
cells,
confers
development
drug
resistance.
In
this
review,
we
first
briefly
introduce
biological
properties
SLC7A11,
including
its
structure
physiological
functions,
further
summarise
regulatory
network
regulators.
Then,
focusing
role
cancer,
describe
relationships
with
tumourigenesis,
survival,
proliferation,
metastasis,
resistance
more
detail.
Finally,
since
been
linked
through
approaches,
propose
contribution
mechanism
require
elucidation.
Thus,
personalised
strategies
should
be
adapted
when
targeting
SLC7A11.
Autophagy,
Год журнала:
2023,
Номер
19(8), С. 2175 - 2195
Опубликована: Апрель 14, 2023
Copper
is
an
essential
trace
element
in
biological
systems,
maintaining
the
activity
of
enzymes
and
function
transcription
factors.
However,
at
high
concentrations,
copper
ions
show
increased
toxicity
by
inducing
regulated
cell
death,
such
as
apoptosis,
paraptosis,
pyroptosis,
ferroptosis,
cuproptosis.
Furthermore,
can
trigger
macroautophagy/autophagy,
a
lysosome-dependent
degradation
pathway
that
plays
dual
role
regulating
survival
or
death
fate
cells
under
various
stress
conditions.
Pathologically,
impaired
metabolism
due
to
environmental
genetic
causes
implicated
variety
human
diseases,
rare
Wilson
disease
common
cancers.
Therapeutically,
copper-based
compounds
are
potential
chemotherapeutic
agents
be
used
alone
combination
with
other
drugs
approaches
treat
cancer.
Here,
we
review
progress
made
understanding
metabolic
processes
their
impact
on
regulation
autophagy.
This
knowledge
may
help
design
future
clinical
tools
improve
cancer
diagnosis
treatment.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Март 8, 2024
Ferroptosis
is
a
non-apoptotic
form
of
regulated
cell
death
characterized
by
the
lethal
accumulation
iron-dependent
membrane-localized
lipid
peroxides.
It
acts
as
an
innate
tumor
suppressor
mechanism
and
participates
in
biological
processes
tumors.
Intriguingly,
mesenchymal
dedifferentiated
cancer
cells,
which
are
usually
resistant
to
apoptosis
traditional
therapies,
exquisitely
vulnerable
ferroptosis,
further
underscoring
its
potential
treatment
approach
for
cancers,
especially
refractory
cancers.
However,
impact
ferroptosis
on
extends
beyond
direct
cytotoxic
effect
cells.
induction
not
only
inhibits
but
also
promotes
development
due
negative
anticancer
immunity.
Thus,
comprehensive
understanding
role
crucial
successful
translation
therapy
from
laboratory
clinical
applications.
In
this
review,
we
provide
overview
recent
advancements
cancer,
covering
molecular
mechanisms,
functions,
regulatory
pathways,
interactions
with
microenvironment.
We
summarize
applications
immunotherapy,
radiotherapy,
systemic
therapy,
well
inhibition
various
conditions.
finally
discuss
markers,
current
challenges
future
directions
cancer.
Journal of Experimental & Clinical Cancer Research,
Год журнала:
2023,
Номер
42(1)
Опубликована: Янв. 6, 2023
Sorafenib
resistance
is
a
key
impediment
to
successful
treatment
of
patients
with
advanced
hepatocellular
carcinoma
(HCC)
and
recent
studies
have
reported
reversal
drug
by
targeting
ferroptosis.
The
present
study
aimed
explore
the
association
fatty
acid
synthase
(FASN)
sorafenib
via
regulation
ferroptosis
provide
novel
strategy
overcome
HCC
patients.Intracellular
levels
lipid
peroxides,
glutathione,
malondialdehyde,
Fe2+
were
measured
as
indicators
status.
Biological
information
analyses,
immunofluorescence
assays,
western
blot
co-immunoprecipitation
analyses
conducted
elucidate
functions
FASN
in
HCC.
Both
vitro
vivo
examine
antitumor
effects
combination
orlistat
CalcuSyn
software
was
used
calculate
index.Solute
carrier
family
7
member
11
(SLC7A11)
found
play
an
important
role
mediating
resistance.
up-regulation
antagonize
SLC7A11-mediated
thereby
promoted
Mechanistically,
enhanced
sorafenib-induced
binding
hypoxia-inducible
factor
1-alpha
(HIF1α),
promoting
HIF1α
nuclear
translocation,
inhibiting
ubiquitination
proteasomal
degradation
HIF1α,
subsequently
enhancing
transcription
SLC7A11.
Orlistat,
inhibitor
FASN,
had
significant
synergistic
reversed
both
vivo.Targeting
FASN/HIF1α/SLC7A11
pathway
resensitized
cells
sorafenib.
superior
sorafenib-resistant
cells.
ACS Nano,
Год журнала:
2023,
Номер
17(20), С. 19581 - 19599
Опубликована: Окт. 11, 2023
Transition
metal
elements,
such
as
copper,
play
diverse
and
pivotal
roles
in
oncology.
They
act
constituents
of
metalloenzymes
involved
cellular
metabolism,
function
signaling
molecules
to
regulate
the
proliferation
metastasis
tumors,
are
integral
components
metal-based
anticancer
drugs.
Notably,
recent
research
reveals
that
excessive
copper
can
also
modulate
occurrence
programmed
cell
death
(PCD),
known
cuprotosis,
cancer
cells.
This
modulation
occurs
through
disruption
tumor
metabolism
induction
proteotoxic
stress.
discovery
uncovers
a
mode
interaction
between
transition
metals
proteins,
emphasizing
intricate
link
homeostasis
metabolism.
Moreover,
they
provide
innovative
therapeutic
strategies
for
precise
diagnosis
treatment
malignant
tumors.
At
crossroads
chemistry
oncology,
we
undertake
comprehensive
review
elucidating
molecular
mechanisms
underpinning
cuproptosis.
Additionally,
summarize
current
nanotherapeutic
approaches
target
cuproptosis
an
overview
available
laboratory
clinical
methods
monitoring
this
process.
In
context
emerging
concepts,
challenges,
opportunities,
emphasize
significant
potential
nanotechnology
advancement
field.
Frontiers in Endocrinology,
Год журнала:
2023,
Номер
14
Опубликована: Март 6, 2023
Ovarian
cancer
(OC)
is
one
of
the
most
common
and
malignant
gynecological
malignancies
in
gynecology.
On
other
hand,
dysregulation
copper
metabolism
(CM)
closely
associated
with
tumourigenesis
progression.
Here,
we
investigated
impact
genes
(CMRGs)
on
prognosis
OC,
discovered
various
CM
clusters,
built
a
risk
model
to
evaluate
patient
prognosis,
immunological
features,
therapy
response.15
CMRGs
affecting
OC
patients
were
identified
The
Cancer
Genome
Atlas
(TCGA).
Consensus
Clustering
was
used
identify
two
clusters.
lasso-cox
methods
establish
metabolism-related
gene
prognostic
signature
(CMRGPS)
based
differentially
expressed
GSE63885
cohort
as
an
external
validation
cohort.
Expression
score-associated
verified
by
single-cell
sequencing
quantitative
real-time
PCR
(qRT-PCR).
Nomograms
visually
depict
clinical
value
CMRGPS.
Differences
traits,
immune
cell
infiltration,
tumor
mutational
load
(TMB)
between
groups
also
extensively
examined.
Tumour
Immune
Dysfunction
Rejection
(TIDE)
Phenotype
Score
(IPS)
validate
whether
CMRGPS
could
predict
response
immunotherapy
patients.In
TCGA
cohorts,
clusters
that
differed
significantly
terms
overall
survival
(OS)
microenvironment.
We
then
created
containing
11
confirmed
its
reliable
predictive
power
for
patients.
expression
score-related
validated
qRT-PCR.
Patients
divided
into
low-risk
(LR)
high-risk
(HR)
median
score,
better
LR
group.
5-year
AUC
reached
0.74.
Enrichment
analysis
showed
group
immune-related
pathways.
results
TIDE
IPS
group.Our
study,
therefore,
provides
valuable
tool
further
guide
management
tailor
treatment
offering
new
insights
individualized
treatment.
Frontiers in Oncology,
Год журнала:
2023,
Номер
13
Опубликована: Июнь 23, 2023
As
an
essential
nutrient,
copper’s
redox
properties
are
both
beneficial
and
toxic
to
cells.
Therefore,
leveraging
the
characteristics
of
copper-dependent
diseases
or
using
copper
toxicity
treat
copper-sensitive
may
offer
new
strategies
for
specific
disease
treatments.
In
particular,
concentration
is
typically
higher
in
cancer
cells,
making
a
critical
limiting
nutrient
cell
growth
proliferation.
Hence,
intervening
metabolism
cells
become
potential
tumor
treatment
strategy,
directly
impacting
metastasis.
this
review,
we
discuss
body
summarize
research
progress
on
role
promoting
inducing
programmed
death
Additionally,
elucidate
copper-related
drugs
treatment,
intending
provide
perspectives
treatment.
Journal of Hematology & Oncology,
Год журнала:
2024,
Номер
17(1)
Опубликована: Июнь 6, 2024
Abstract
Ferroptosis,
an
iron-dependent
form
of
cell
death
characterized
by
uncontrolled
lipid
peroxidation,
is
governed
molecular
networks
involving
diverse
molecules
and
organelles.
Since
its
recognition
as
a
non-apoptotic
pathway
in
2012,
ferroptosis
has
emerged
crucial
mechanism
numerous
physiological
pathological
contexts,
leading
to
significant
therapeutic
advancements
across
wide
range
diseases.
This
review
summarizes
the
fundamental
mechanisms
regulatory
pathways
underlying
ferroptosis,
including
both
GPX4-dependent
-independent
antioxidant
mechanisms.
Additionally,
we
examine
involvement
various
conditions,
cancer,
neurodegenerative
diseases,
sepsis,
ischemia–reperfusion
injury,
autoimmune
disorders,
metabolic
disorders.
Specifically,
explore
role
response
chemotherapy,
radiotherapy,
immunotherapy,
nanotherapy,
targeted
therapy.
Furthermore,
discuss
pharmacological
strategies
for
modulating
potential
biomarkers
monitoring
this
process.
Lastly,
elucidate
interplay
between
other
forms
regulated
death.
Such
insights
hold
promise
advancing
our
understanding
context
human
health
disease.
Immunological Reviews,
Год журнала:
2023,
Номер
321(1), С. 211 - 227
Опубликована: Сен. 16, 2023
Summary
Copper
is
an
essential
nutrient
for
maintaining
enzyme
activity
and
transcription
factor
function.
Excess
copper
results
in
the
aggregation
of
lipoylated
dihydrolipoamide
S‐acetyltransferase
(DLAT),
which
correlates
to
mitochondrial
tricarboxylic
acid
(TCA)
cycle,
resulting
proteotoxic
stress
eliciting
a
novel
cell
death
modality:
cuproptosis.
Cuproptosis
exerts
indispensable
role
cancer
progression,
considered
promising
strategy
therapy.
Cancer
immunotherapy
has
gained
extensive
attention
owing
breakthroughs
immune
checkpoint
blockade;
furthermore,
cuproptosis
strongly
connected
modulation
antitumor
immunity.
Thus,
thorough
recognition
concerning
mechanisms
involved
metabolism
may
facilitate
improvement
management.
This
review
outlines
cellular
molecular
characteristics
links
regulated
modality
with
human
cancers.
We
also
current
knowledge
on
complex
effects
immunity
response.
Furthermore,
potential
agents
that
elicit
pathways
are
summarized.
Lastly,
we
discuss
influence
induction
tumor
microenvironment
as
well
challenges
adding
regulators
therapeutic
strategies
beyond
traditional