Cuproptosis: A novel therapeutic target for overcoming cancer drug resistance

Drug Resistance Updates, Год журнала: 2023, Номер 72, С. 101018 - 101018

Опубликована: Ноя. 11, 2023

Cuproptosis is a newly identified form of cell death driven by copper. Recently, the role copper and triggered in pathogenesis cancers have attracted attentions. has garnered enormous interest cancer research communities because its great potential for therapy. Copper-based treatment exerts an inhibiting tumor growth may open door chemotherapy-insensitive tumors. In this review, we provide critical analysis on homeostasis dysregulation development progression cancers. Then core molecular mechanisms cuproptosis discussed, followed summarizing current understanding copper-based agents (copper chelators, ionophores, complexes-based dynamic therapy) treatment. Additionally, summarize emerging data ionophores to subdue chemotherapy resistance different types We also review small-molecule compounds nanoparticles (NPs) that kill cells inducing cuproptosis, which will shed new light anticancer drugs through future. Finally, important concepts pressing questions future should be focused were discussed. This article suggests targeting could novel antitumor therapy strategy overcome drug resistance.

Язык: Английский

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Copper homeostasis and cuproptosis in cardiovascular disease therapeutics

Trends in Pharmacological Sciences, Год журнала: 2023, Номер 44(9), С. 573 - 585

Опубликована: Июль 25, 2023

Язык: Английский

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Copper homeostasis and cuproptosis in cancer immunity and therapy

Immunological Reviews, Год журнала: 2023, Номер 321(1), С. 211 - 227

Опубликована: Сен. 16, 2023

Summary Copper is an essential nutrient for maintaining enzyme activity and transcription factor function. Excess copper results in the aggregation of lipoylated dihydrolipoamide S‐acetyltransferase (DLAT), which correlates to mitochondrial tricarboxylic acid (TCA) cycle, resulting proteotoxic stress eliciting a novel cell death modality: cuproptosis. Cuproptosis exerts indispensable role cancer progression, considered promising strategy therapy. Cancer immunotherapy has gained extensive attention owing breakthroughs immune checkpoint blockade; furthermore, cuproptosis strongly connected modulation antitumor immunity. Thus, thorough recognition concerning mechanisms involved metabolism may facilitate improvement management. This review outlines cellular molecular characteristics links regulated modality with human cancers. We also current knowledge on complex effects immunity response. Furthermore, potential agents that elicit pathways are summarized. Lastly, we discuss influence induction tumor microenvironment as well challenges adding regulators therapeutic strategies beyond traditional

Язык: Английский

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The copper age in cancer treatment: From copper metabolism to cuproptosis

Progress in Materials Science, Год журнала: 2023, Номер 138, С. 101145 - 101145

Опубликована: Май 23, 2023

Язык: Английский

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Crosstalk between ferroptosis and cuproptosis: From mechanism to potential clinical application

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 171, С. 116115 - 116115

Опубликована: Янв. 5, 2024

Ferroptosis and cuproptosis, regulated forms of cell death resulting from metal ion accumulation, are closely related in terms occurrence, metabolism, signaling pathways, drug resistance. Notably, it is now understood that these processes play crucial roles regulating physiological pathological processes, especially tumor development. Consequently, ferroptosis cuproptosis have gained increasing significance as potential targets for anti-cancer This article systematically outlines the molecular mechanisms cross-talk components both elucidating their impacts on cancer. Furthermore, investigates clinical perspective targeted cancer chemotherapy, immunotherapy, radiotherapy. Our discussion extends to a comparative analysis nanoparticles developed based cancer, contrasting them with current conventional therapies. Opportunities challenges treatment explored, emphasizing therapeutic direction co-targeting cuproptosis. The also attempts analyze applications this approach while summarizing existing barriers require overcoming.

Язык: Английский

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Comprehensive Insights into Medicinal Research on Imidazole-Based Supramolecular Complexes

Pharmaceutics, Год журнала: 2023, Номер 15(5), С. 1348 - 1348

Опубликована: Апрель 27, 2023

The electron-rich five-membered aromatic aza-heterocyclic imidazole, which contains two nitrogen atoms, is an important functional fragment widely present in a large number of biomolecules and medicinal drugs; its unique structure beneficial to easily bind with various inorganic or organic ions molecules through noncovalent interactions form variety supramolecular complexes broad potential, being paid increasing amount attention regarding more contributions imidazole-based for possible application. This work gives systematical comprehensive insights into research on complexes, including anticancer, antibacterial, antifungal, antiparasitic, antidiabetic, antihypertensive, anti-inflammatory aspects as well ion receptors, imaging agents, pathologic probes. new trend the foreseeable near future toward chemistry also prospected. It hoped that this provides help rational design drug agents effective diagnostic pathological

Язык: Английский

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Copper Metabolism and Cuproptosis: Molecular Mechanisms and Therapeutic Perspectives in Neurodegenerative Diseases

Current Medical Science, Год журнала: 2024, Номер 44(1), С. 28 - 50

Опубликована: Фев. 1, 2024

Abstract Copper is an essential trace element, and plays a vital role in numerous physiological processes within the human body. During normal metabolism, body maintains copper homeostasis. deficiency or excess can adversely affect cellular function. Therefore, homeostasis stringently regulated. Recent studies suggest that trigger specific form of cell death, namely, cuproptosis, which triggered by excessive levels intracellular copper. Cuproptosis induces aggregation mitochondrial lipoylated proteins, loss iron-sulfur cluster proteins. In neurodegenerative diseases, pathogenesis progression neurological disorders are linked to This review summarizes advances cuproptosis nervous system diseases. offers research perspectives provide new insights into targeted treatment diseases based on cuproptosis.

Язык: Английский

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Cuproptosis: unveiling a new frontier in cancer biology and therapeutics

Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)

Опубликована: Май 1, 2024

Copper plays vital roles in numerous cellular processes and its imbalance can lead to oxidative stress dysfunction. Recent research has unveiled a unique form of copper-induced cell death, termed cuproptosis, which differs from known death mechanisms. This process involves the interaction copper with lipoylated tricarboxylic acid cycle enzymes, causing protein aggregation death. Recently, growing number studies have explored link between cuproptosis cancer development. review comprehensively examines systemic metabolism copper, including tumor-related signaling pathways influenced by copper. It delves into discovery mechanisms connection various cancers. Additionally, suggests potential treatments using ionophores that induce combination small molecule drugs, for precision therapy specific types.

Язык: Английский

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Unveiling the potential of HKUST-1: synthesis, activation, advantages and biomedical applications

Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(11), С. 2670 - 2690

Опубликована: Янв. 1, 2024

HKUST-1 represents a promising biomaterial, functioning not only as drug carrier but also releasing bioactive copper ions, thereby demonstrating exceptional antitumor, antibacterial, and wound healing properties.

Язык: Английский

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MOF/MXene-loaded PVA/chitosan hydrogel with antimicrobial effect and wound healing promotion under electrical stimulation and improved mechanical properties

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 264, С. 130625 - 130625

Опубликована: Март 6, 2024

Язык: Английский

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