Current Opinion in Gastroenterology, Год журнала: 2023, Номер 39(3), С. 169 - 174
Опубликована: Март 28, 2023
Infection with hepatitis E virus (HEV) is a global health concern, yet clinically underdiagnosed cause of acute and chronic hepatitis. The WHO estimates that 20 million people are infected HEV annually, the epidemiology, diagnosis prevention remain elusive in many clinical settings.
Язык: Английский
Cancers, Год журнала: 2023, Номер 15(2), С. 533 - 533
Опубликована: Янв. 15, 2023
Hepatocellular carcinoma (HCC) remains a global health challenge, causing 600,000 deaths each year. Infectious factors, including hepatitis B virus (HBV), C (HCV) and D (HDV), have long been considered the major risk factors for development progression of HCC. These pathogens induce hepatocyte transformation through variety mechanisms, insertional mutations caused by viral gene integration, epigenetic changes, induction long-term immune dysfunction. The discovery these while advancing our understanding disease, also provides targets new diagnostic therapeutic approaches. In addition, research chronic HEV infection over past decade indicate that this common seems to potential review, we provide an overview recent studies on link between HCC, as well approaches HCC based findings. Finally, discuss relationship conclusion, associations will further optimize diagnosis treatment infection-associated call better management policies.
Язык: Английский
Процитировано
76
The Lancet, Год журнала: 2024, Номер 403(10429), С. 813 - 823
Опубликована: Фев. 19, 2024
Язык: Английский
Процитировано
27
Journal of Viral Hepatitis, Год журнала: 2025, Номер 32(3)
Опубликована: Фев. 10, 2025
Hepatitis E virus (HEV) infection is a frequent cause of acute viral hepatitis. Immunocompromised patients, especially those under anti-CD20 regimens, are prone to chronic or treatment-resistant courses hepatitis E. We report case HEV in 36-year-old man with history thrombotic thrombocytopenic purpura treated rituximab 6 months ago, who presented new-onset painless jaundice and malaise. Laboratory tests imaging revealed signs inflammation hepatic dysfunction. Due initial suspicion autoimmune hepatitis, corticosteroid therapy was started. However, liver biopsy positive RNA value redefined the diagnosis. Serology initially infection, which later progressed infection. Treatment ribavirin, along supportive care, achieved significant clinical laboratory improvement, resolving jaundice, restoring normal transaminase suppressing values. Further review literature highlights impact immunosuppression caused by therapies on as well challenges both treatment achieving sustained clearance such patients. Moreover, this underlines importance screening patients have undergone therapies, shedding light situation that not described should be overlooked, even developed countries.
Язык: Английский
Процитировано
2
Ageing Research Reviews, Год журнала: 2023, Номер 91, С. 102068 - 102068
Опубликована: Сен. 12, 2023
Alzheimer's disease (AD) represents the most frequent type of dementia in elderly people. Two major forms exist: sporadic - causes which have not yet been fully understood and familial inherited within families from generation to generation, with a clear autosomal dominant transmission mutations Presenilin 1 (PSEN1), 2 (PSEN2) or Amyloid Precursors Protein (APP) genes. The main hallmark AD consists extracellular deposits amyloid-beta (Aβ) peptide intracellular hyperphosphorylated form tau protein. An ever-growing body research supports viral infectious hypothesis AD. In particular, it has shown that several herpes viruses (i.e., HHV-1, HHV-2, HHV-3 varicella zoster virus, HHV-4 Epstein Barr HHV-5 cytomegalovirus, HHV-6A B, HHV-7), flaviviruses Zika Dengue fever Japanese encephalitis virus) as well Human Immunodeficiency Virus (HIV), hepatitis (HAV, HBV, HCV, HDV, HEV), SARS-CoV2, Ljungan virus (LV), Influenza A Borna could increase risk Here, we summarized discussed these results. Based on findings, significant issues for future studies are also put forward.
Язык: Английский
Процитировано
39
Gastroenterology, Год журнала: 2024, Номер unknown
Опубликована: Апрель 1, 2024
Язык: Английский
Процитировано
15
Viruses, Год журнала: 2024, Номер 16(6), С. 842 - 842
Опубликована: Май 24, 2024
Hepatitis E virus (HEV) can cause self-limiting acute and chronic hepatitis infections, particularly in immunocompromised individuals. In developing countries, HEV is mainly transmitted via drinking contaminated water, whereas zoonotic transmission dominates the route of infection developed including Japan. Pigs are an important reservoir for infection. Wild boars, which share same genus species as domestic pigs, also reservoir. During our nationwide study wild boar populations Japan, a genotype 6 (HEV-6) strain, wbJHG_23, was isolated Hyogo Prefecture 2023. The genomic length 7244 nucleotides, excluding poly(A) tract. wbJHG_23 strain exhibited highest nucleotide identity throughout its genome with two previously reported HEV-6 strains (80.3–80.9%). Conversely, it displayed lower similarity (73.3–78.1%) HEV-1–5, HEV-7, HEV-8 strains, indicating that, although closely related, differs significantly from might represent novel subtype. successfully infected human-derived cancer cell lines, PLC/PRF/5 A549 1-1H8 cells, suggesting that has potential An infectious cDNA clone constructed using reverse genetics system, culture system supporting efficient propagation established, providing tools further studies on this genotype. Using we evaluated sensitivity to ribavirin treatment. Its good response treatment suggested could be used treat human infections caused by HEV-6.
Язык: Английский
Процитировано
9
Signal Transduction and Targeted Therapy, Год журнала: 2025, Номер 10(1)
Опубликована: Фев. 4, 2025
Abstract As a highly complex organ with digestive, endocrine, and immune-regulatory functions, the liver is pivotal in maintaining physiological homeostasis through its roles metabolism, detoxification, immune response. Various factors including viruses, alcohol, metabolites, toxins, other pathogenic agents can compromise function, leading to acute or chronic injury that may progress end-stage diseases. While sharing common features, diseases exhibit distinct pathophysiological, clinical, therapeutic profiles. Currently, contribute approximately 2 million deaths globally each year, imposing significant economic social burdens worldwide. However, there no cure for many kinds of diseases, partly due lack thorough understanding development these Therefore, this review provides comprehensive examination epidemiology characteristics covering spectrum from conditions manifestations. We also highlight multifaceted mechanisms underlying initiation progression spanning molecular cellular levels networks. Additionally, offers updates on innovative diagnostic techniques, current treatments, potential targets presently under clinical evaluation. Recent advances pathogenesis hold critical implications translational value novel strategies.
Язык: Английский
Процитировано
1
Viruses, Год журнала: 2023, Номер 15(7), С. 1558 - 1558
Опубликована: Июль 16, 2023
Hepatitis E virus (HEV) is one of the leading causes acute viral hepatitis. Transmission HEV mainly occurs via fecal-oral route (ingesting contaminated water or food) by contact with infected animals and their raw meat products. Some animals, such as pigs, wild boars, sheep, goats, rabbits, camels, rats, etc., are natural reservoirs HEV, which places people in close them at increased risk disease. Although hepatitis a self-limiting infection, it could also lead to severe illness, particularly among pregnant women, chronic infection immunocompromised people. A growing number studies point out that can be classified re-emerging developed countries. Preventative efforts needed reduce incidence non-endemic endemic There recombinant vaccine, but approved for use commercially available only China Pakistan. However, further demonstrate necessity applying preventive vaccine create conditions reducing spread HEV. This review emphasizes its importance public health Europe, methods transmission treatment, summarizes latest on development.
Язык: Английский
Процитировано
19
Hepatology International, Год журнала: 2024, Номер 18(3), С. 917 - 928
Опубликована: Март 26, 2024
Язык: Английский
Процитировано
7
Emerging Microbes & Infections, Год журнала: 2024, Номер 13(1)
Опубликована: Март 22, 2024
Globally, hepatitis E virus (HEV) infections are prevalent. The finding of high viral loads and persistent shedding in ejaculate suggests that HEV replicates within the human male genital tract, but its target organ is unknown appropriate models lacking. We aimed to determine tropism testis potential influence on reproductive health. conducted ex vivo culture explants vitro primary Sertoli cells. Clinically derived genotype 1 (HEV1) HEV3 virions, as well rat HEV-C1, were used for inoculation. Transcriptomic analysis was performed tissues collected from tacrolimus-treated rabbits with chronic infection. Our findings reveal HEV3, not HEV1 or can replicate Tacrolimus treatment significantly enhanced replication efficiency enabled successful infection disrupted secretion several soluble factors altered cytokine microenvironment Finally, intratesticular transcriptomic immunocompromised indicated a downregulation genes associated spermatogenesis. infect testicular cells, increased when exposed tacrolimus treatment. These shed light how may persist patients provide valuable tool studying countermeasures.
Язык: Английский
Процитировано
6