Gut,
Год журнала:
2024,
Номер
unknown, С. gutjnl - 332508
Опубликована: Июнь 5, 2024
Background
Hepatocellular
carcinoma
(HCC)
is
plagued
by
failures
across
the
cancer
care
continuum,
leading
to
frequent
late-stage
diagnoses
and
high
mortality.
We
evaluated
effectiveness
of
mailed
outreach
invitations
plus
patient
navigation
promote
HCC
screening
process
completion
in
patients
with
cirrhosis.
Methods
Between
April
2018
September
2021,
we
conducted
a
multicentre
pragmatic
randomised
clinical
trial
comparing
for
(n=1436)
versus
usual
visit-based
among
cirrhosis
at
three
US
health
systems.
Our
primary
outcome
was
over
36-month
period,
our
secondary
proportion
time
covered
(PTC)
screening.
All
were
included
intention-to-screen
analyses.
Results
2872
participants
(median
age
61.3
years;
32.3%
women)
Screening
observed
6.6%
(95%
CI:
5.3%
7.9%)
3.3%
2.4%
4.3%)
those
(OR
2.05,
95%
1.44
2.92).
The
intervention
increased
most
subgroups
including
age,
sex,
race
ethnicity,
Child-Turcotte-Pugh
class
system.
PTC
also
significantly
higher
arm
than
(mean
37.5%
vs
28.2%;
RR
1.33,
1.31
1.35).
Despite
underuse,
both
arms
detected
an
early
stage.
Conclusion
Mailed
cirrhosis,
consistent
effect
examined
subgroups.
However,
remained
suboptimal
arms,
underscoring
need
more
intensive
interventions.
Trial
registration
number
NCT02582918
.
Egyptian Liver Journal,
Год журнала:
2024,
Номер
14(1)
Опубликована: Янв. 2, 2024
Abstract
Background
Hepatocellular
carcinoma
(HCC)
is
a
common
type
of
liver
cancer,
with
high
mortality
rate.
cancer
that
can
be
effectively
managed
through
early
detection
and
accurate
diagnosis,
followed
by
personalized
treatment
plan
may
include
surgical
resection,
transplantation,
minimally-invasive
techniques,
immunotherapy,
or
targeted
therapy
depending
on
the
stage
severity
cancer.
Main
body
abstract
This
paper
discusses
recent
advances
in
detection,
management,
prevention
HCC.
The
use
newer
imaging
such
as
Magnetic
resonance
(MRI)
contrast-enhanced
ultrasound,
along
image
segmentation
technology
deep
learning
models,
have
greatly
enhanced
accuracy
HCC
diagnosis.
Minimally-invasive
thermal
ablation
radiofrequency
ablation,
allowed
for
more
precise
destruction
tumors,
while
Nanoparticles,
immunotherapy
shown
promise
management
advanced
Artificial
intelligence
(AI)
machine
has
revolutionized
research,
aiding
identification
high-risk
patients
predicting
outcomes.
Lifestyle
modifications,
weight
alcohol
avoidance,
hepatitis
B
vaccinations,
play
critical
role
preventing
development.
Short
conclusion
Recent
improving
patient
therapy,
AI
research
lifestyle
modifications
prevention.
However,
further
required
to
fully
understand
potential
benefits
nanoparticles,
traditional
Chinese
medicine
herbal
medicines
treatment.
Graphical
Molecules,
Год журнала:
2025,
Номер
30(3), С. 484 - 484
Опубликована: Янв. 22, 2025
We
present
a
lateral
flow
aptasensor
for
the
visual
detection
of
alpha-fetoprotein
(AFP)
in
human
serum.
Leveraging
precise
molecular
recognition
capabilities
aptamers
and
distinct
optical
features
gold
nanoparticles,
model
system
utilizing
AFP
as
target
analyte,
along
with
pair
aptamer
probes,
is
implemented
to
establish
proof-of-concept
on
standard
test
strips.
It
first
report
an
antibody-free
assay
using
probes
AFP.
The
analysis
circumvents
numerous
incubation
washing
steps
that
are
typically
involved
most
current
aptamer-based
protein
assays.
Qualitative
involves
observing
color
changes
area,
while
quantitative
data
obtained
by
measuring
response
zone
portable
strip
reader.
biosensor
exhibits
linear
range
concentrations
between
10
100
ng/mL,
minimum
limit
ng/mL.
Additionally,
it
has
been
successfully
applied
detect
serum
samples.
use
aptamer-functionalized
nanoparticle
offers
great
promise
point-of-care
applications
fast,
on-site
detection.
Hepatology,
Год журнала:
2023,
Номер
79(1), С. 107 - 117
Опубликована: Июль 4, 2023
Background
and
Aims:
The
value
of
HCC
surveillance
is
determined
by
the
balance
between
benefits
harms;
however,
no
studies
have
enumerated
psychological
harms.
Approach
Results:
We
fielded
surveys
measuring
harms
to
patients
with
cirrhosis
in
a
multicenter
randomized
trial
outreach.
All
positive
or
indeterminate
results
matched
negative
were
invited
complete
(1)
depression
through
Patient
Health
Questionnaire-ninth
version,
(2)
anxiety
State-Trait
Anxiety
Inventory,
(3)
HCC-specific
worry
Psychological
Consequences
Questionnaire,
(4)
decisional
regret.
Patients
classified
into
4
groups:
true
(TP),
false
(FP),
indeterminate,
(TN).
Multivariable
longitudinal
regression
analysis
using
generalized
estimating
equation
method
was
performed
compare
means
measures
across
groups.
conducted
89
semistructured
interviews
subset
stratified
health
system
test
results.
Of
2872
trial,
311
completed
1+
follow-up
survey
(63
FP,
77
38
TP,
133
TN).
Moderate
decreased
TN
patients,
increased
had
intermittent
but
mild
increases
those
FP
High
temporarily
TP
resolved
over
time
stable
Decisional
regret
low
did
not
differ
In
interviews,
reported
apprehension,
anxiety,
emotional
distress,
coping
related
surveillance.
Conclusions:
appear
result.
Future
research
should
determine
impact
on
programs.
