Advancements in Regenerative Medicine for Aesthetic Dermatology: A Comprehensive Review and Future Trends
Cosmetics,
Год журнала:
2024,
Номер
11(2), С. 49 - 49
Опубликована: Март 31, 2024
The
growing
interest
in
maintaining
a
youthful
appearance
has
encouraged
an
accelerated
development
of
innovative,
minimally
invasive
aesthetic
treatments
for
facial
rejuvenation
and
regeneration.
close
correlation
between
tissue
repair,
regeneration,
aging
paved
the
way
application
regenerative
medicine
principles
cosmetic
dermatology.
theoretical
substrates
applications
dermo-aesthetics
are
plentiful.
However,
dermatology
is
emerging
field
needs
more
data
vivo
trials
to
reach
consensus
on
standardization
methods.
In
this
review,
we
summarize
techniques
as
they
apply
dermatology,
suggesting
unexplored
fields
future
directions.
Язык: Английский
Alloferon and IL-22 receptor expression regulation on the pathogenesis of imiquimod-induced psoriasis
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Фев. 24, 2025
Язык: Английский
The acid sphingomyelinase inhibitor imipramine enhances the release of UV photoproduct‐containing DNA in small extracellular vesicles in UVB‐irradiated human skin
Photochemistry and Photobiology,
Год журнала:
2024,
Номер
100(6), С. 1894 - 1901
Опубликована: Март 3, 2024
Nucleic
acids,
lipids,
and
other
cell
components
can
be
found
within
different
types
of
extracellular
vesicles
(EVs),
which
include
apoptotic
bodies
(ABs),
large
(LEVs),
small
(SEVs).
Release
LEVs
from
cells
reduced
by
genetic
or
pharmacological
inhibition
the
enzyme
acid
sphinogomyelinase
(aSMase),
indeed
several
studies
have
demonstrated
a
role
for
clinically
approved
aSMase
inhibitor
imipramine
in
blocking
LEV
release,
including
response
to
UVB
exposure.
Given
that
exposure
keratinocytes
radiation
results
generation
UVR
photoproducts
DNA
subsequently
association
with
ABs
SEVs,
we
examined
how
impacts
release
containing
at
an
early
time
point
after
Using
model
systems,
cultured
vitro,
discarded
human
surgical
skin
ex
vivo,
biopsies
obtained
treated
subjects,
these
pilot
suggest
treatment
stimulates
CPD-containing,
SEV-associated
DNA.
These
surprising
findings
indicate
SEV
pathways
could
linked
UVB-irradiated
may
exacerbate
systemic
effects
UVR-damaged
throughout
body.
Язык: Английский
Lactobacillus rhamnosus GG-derived extracellular vesicles promote wound healing via miR-21-5p-mediated re-epithelization and angiogenesis
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Окт. 19, 2024
Extracellular
vesicles
(EVs),
especially
those
derived
from
stem
cells,
have
emerged
as
a
novel
treatment
for
promoting
wound
healing
in
regenerative
medicine.
However,
the
clinical
application
of
mammalian
cells-derived
EVs
is
hindered
by
their
high
cost
and
low
yields.
Inspired
ability
to
mediate
interkingdom
communication,
we
explored
therapeutic
potential
released
probiotic
strain
Lactobacillus
rhamnosus
GG
(LGG)
skin
elucidated
underlying
mechanism
involved.
Using
full-thickness
wound-healing
mouse
models,
found
that
LGG-EVs
accelerated
procedures,
including
increased
re-epithelialization
promoted
angiogenesis.
vitro
experiments,
further
demonstrated
boosted
proliferation
migration
capacities
both
epithelial
endothelial
well
tube
formation.
miRNA
profiling
analysis
revealed
miR-21-5p
was
highly
enriched
LGG-EV
significantly
level
recipient
cells.
Mechanically,
induced
regulatory
effects
via
mediated
metabolic
signaling
rewiring.
Our
results
suggest
LGG
could
serve
promising
candidate
accelerating
possibly
treating
chronic
impaired
conditions.
Язык: Английский