Cutaneous adaptive immunity and uraemia: a narrative review DOI Creative Commons
Noushin Zibandeh, Ze-Hua Li, Graham S. Ogg

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Сен. 27, 2024

Chronic kidney disease affects 1 in 10 people globally, with a prevalence twenty times that of cancer. A subset individuals will progress to end-stage renal (ESRD) where replacement therapy is required maintain health. Cutaneous disease, including xerosis and pruritus, are endemic amongst patients ESRD. In the uraemia-associated immune deficiency ESRD, impaired circulating responses contribute increased infection risk poorer vaccination response. Clinical manifestations dysregulated adaptive immunity within skin have been well-described posited play role cutaneous features However, our understanding mechanisms by which affected uraemia relatively limited. We provide an overview how system impacted both directly indirectly uraemia, highlighting much work has extrapolated from often not evaluated compartment. identify knowledge gaps may be addressed future research. Ultimately, greater these pathways facilitate novel therapeutic approaches ameliorate widespread symptomatology

Язык: Английский

A consensus single-cell transcriptomic atlas of dermal fibroblast heterogeneity DOI Creative Commons
Alex M. Ascensión, Ander Izeta

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Сен. 10, 2024

Single-cell RNA sequencing (scRNAseq) studies have unveiled large transcriptomic heterogeneity within both human and mouse dermal fibroblasts, but a consensus atlas that spans species is lacking. Here, by studying 25 9 datasets through semi-supervised procedure, we categorize 15 distinct fibroblast populations across 5 main axes. Analysis of markers characteristic each population suggested diverse functions, such as position-dependent ECM synthesis, association with immune responses or structural roles in skin appendages. Similarly, fibroblasts were categorized into 17 Comparison highlighted similarities suggesting degree functional overlap, though nuanced differences also noted: transcriptomically, axes seem to segregate function, while prioritize positional information over function. Importantly, addition newer did not significantly change the defined structure. This study enhances our understanding diversity, shedding light on species-specific distinctions well shared functionalities.

Язык: Английский

Процитировано

1
Cutaneous adaptive immunity and uraemia: a narrative review DOI Creative Commons
Noushin Zibandeh, Ze-Hua Li, Graham S. Ogg

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Сен. 27, 2024

Chronic kidney disease affects 1 in 10 people globally, with a prevalence twenty times that of cancer. A subset individuals will progress to end-stage renal (ESRD) where replacement therapy is required maintain health. Cutaneous disease, including xerosis and pruritus, are endemic amongst patients ESRD. In the uraemia-associated immune deficiency ESRD, impaired circulating responses contribute increased infection risk poorer vaccination response. Clinical manifestations dysregulated adaptive immunity within skin have been well-described posited play role cutaneous features However, our understanding mechanisms by which affected uraemia relatively limited. We provide an overview how system impacted both directly indirectly uraemia, highlighting much work has extrapolated from often not evaluated compartment. identify knowledge gaps may be addressed future research. Ultimately, greater these pathways facilitate novel therapeutic approaches ameliorate widespread symptomatology

Язык: Английский

Процитировано

1