Stricto Sensu Editora eBooks, Год журнала: 2023, Номер unknown, С. 31 - 50
Опубликована: Дек. 1, 2023
Cureus, Год журнала: 2023, Номер unknown
Опубликована: Март 27, 2023
The incessant occurrence of devastating health-related events, either on a large scale, such as pandemics, or in local community the form sporadic outbreaks due to infectious agents, warrants rapid, target-oriented, well-organized response team combat demonic consequences. While world has been recovering from clutches recent disastrous COVID-19 pandemic, struggles against novel emerging and re-emerging pathogens monkeypox (mpox), newer evolving strains influenza, Ebola, Zika, yellow fever virus continue date. Therefore, multisectoral, intercontinental, collaborative, interdisciplinary, highly dedicated approach should always be implemented achieve optimal health avert future threats.
Язык: Английский
Процитировано
19
Nature Communications, Год журнала: 2024, Номер 15(1)
Опубликована: Апрель 16, 2024
Abstract The eradication of smallpox was officially declared by the WHO in 1980, leading to discontinuation vaccination campaign against virus. Consequently, immunity and related orthopoxviruses like Monkeypox virus gradually declines, highlighting need for efficient countermeasures not only prevention, but also treatment already exposed individuals. We have recently developed human-like monoclonal antibodies (mAbs) from vaccinia virus-immunized non-human primates. Two mAbs, MV33 EV42, targeting two infectious forms virus, were selected vivo evaluation, based on their vitro neutralization potency. A single dose either or EV42 administered three days post-infection (dpi) BALB/c female mice provides full protection lethal ectromelia challenge. Importantly, a combination both mAbs confers even when provided five dpi. Whole-body bioimaging viral load analysis reveal that allows faster more clearance target organs compared separately. combined further post-exposure currently circulating Cast/EiJ mice, therapeutic potential other orthopoxviruses.
Язык: Английский
Процитировано
6
iScience, Год журнала: 2023, Номер 27(1), С. 108601 - 108601
Опубликована: Дек. 1, 2023
The monkeypox virus (Mpoxv) Clade IIb viruses that caused an outbreak in 2017-18 Nigeria and its genetically related have been detected many countries multi-country 2022. Since the pandemic-causing Mpoxv are closely to IIa which mostly cause endemic, might certain specific genetic variations still largely unknown. Here, we systematically analyzed alterations different clades of Mpox viruses. results suggest terms genomic gaps, frameshift mutations, in-frame nonsense amino acid tandem repeats, APOBEC3 mutations. Further, observed multiple genes for I IIb, exclusive IIb. Collectively, findings shed light on evolution 2022 causing
Язык: Английский
Процитировано
13
Libyan Journal of Medicine, Год журнала: 2023, Номер 18(1)
Опубликована: Июнь 10, 2023
Objectives: This research aims to assess the base level of knowledge and attitude Applied Medical Sciences Students regarding mpox whether an educational intervention could improve their attitude. Methods: A quasi-experimental was used, involving 960 medical students from College at Prince Sattam Bin Abdulaziz University, KSA. They were recruited beginning November 2022 till mid January 2023 based on non-randomized sampling method. standardized, anonymous, closed-ended questionnaire compromising three main sections: participants' demographics, knowledge, attitudes toward epidemic. Results: Total scores studied sample in pretest phase 45.43 ± 6.29 compared 65.03 2.93 post-test phase. Besides, total 48.62 4.78 before program implementation, while after conducting reached 70.65 5.13. There a notable improvement score implemented, particularly for neurological manifestations. Conclusion: After program's there obvious students' concerning It is necessary initiate well-organized training initiatives all other faculties, paramedics, applied health institutions Saudi Arabia.
Язык: Английский
Процитировано
12
Journal of Clinical Microbiology, Год журнала: 2023, Номер 62(1)
Опубликована: Дек. 14, 2023
ABSTRACT There is a need in clinical microbiology and public health for assays that enable sensitive rapid detection of infectious agents. Next Generation Sequencing (NGS) increasingly used the fields oncology personalized genome medicine but has not gained wider acceptance due to operational bioinformatics complexity, as well lower sensitivity compared agent-specific quantitative polymerase chain reaction (qPCR) assays. VirCapSeq-VERT positive selection system detection, typing, strain differentiation both RNA DNA viruses with comparable qPCR. Here we report analytical validation plasma nasal secretions cause systemic and/or respiratory infections. IMPORTANCE Broad range assay accurate diagnostics.
Язык: Английский
Процитировано
10
International Journal of Infectious Diseases, Год журнала: 2023, Номер 134, С. 303 - 306
Опубликована: Июль 15, 2023
The study aims to explore the risk factors, clinical characteristics, and outcomes of mpox infection in Abu Dhabi, United Arab Emirates (UAE).
Язык: Английский
Процитировано
9
The Journal of Microbiology, Год журнала: 2024, Номер 62(5), С. 337 - 354
Опубликована: Май 1, 2024
Язык: Английский
Процитировано
3
Transboundary and Emerging Diseases, Год журнала: 2024, Номер 2024(1)
Опубликована: Янв. 1, 2024
The Democratic Republic of Congo (DRC) faces a syndemic infectious diseases, including monkeypox (mpox), cholera, measles, anthrax, and plague, worsening public health challenges socioeconomic disparities. This review synthesizes discusses epidemiological data consequences simultaneous outbreaks in the DRC between January 2023 March 2024. findings highlight 6.7% fatality rate 3319 confirmed cases mpox, with significant Kinshasa 22 other provinces. Anthrax occasionally surfaced among cattle‐raising villages, measles affected fewer than five children susceptible to disease, cholera persisted North Kivu, South Tanganyika. Plague incidences, mostly bubonic, have been reported Ituri province. Vulnerable groups, children, mothers, elderly, those compromised immune systems, face increased risks due poor healthcare access, hunger, underlying medical conditions. Cultural beliefs, system issues, instability impede effective response tactics. strain on fragile highlights need for surveillance, immunization efforts, community involvement. To mitigate effects outbreaks, strengthening DRC’s systems through international cooperation, integrated initiatives, improved access is crucial.
Язык: Английский
Процитировано
3
In Silico Pharmacology, Год журнала: 2025, Номер 13(1)
Опубликована: Янв. 30, 2025
Язык: Английский
Процитировано
0
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Авг. 22, 2024
Abstract Mpox is a zoonotic disease caused by the Monkeypox virus (MPXV) in family: Poxviridae, genus: Orthopoxvirus. Historically, was restricted mostly to Africa with cases being reported Central (mostly clade I) and West (caused II). However, there has been recent shift range outbreaks Europe America, countries where initially not endemic. This multi-country outbreak driven IIb lineage of MPXV. Since December 2023, an ongoing mpox Democratic Republic Congo (DRC), new I virus, designated Ib. The DRC persisted, increase over past few months. Spillover these outbreak-related neighbouring have also multiple including Uganda Rwanda. Here, we report rapid application unbiased metagenomic next generation sequencing (mNGS) reconstruct genome sequence first case MPXV Kenya. Our findings show that Kenyan clusters together Ib strains, associated sustained DRC. Clade continuing geographical expansion previously unaffected areas, high incidence as well fatality (CFR 4.9-6.7%). Similar other strain carries predominant APOBEC3-type mutations which characteristic feature human-to-human transmission, highlighting need for surveillance curtail any potential this strain. lack information on genomes different East African countries, gap urgently needs be addressed aid monitoring investigation, therefore, underscores efforts enhanced across continent help improve our understanding diversity especially those belonging currently under-represented.
Язык: Английский
Процитировано
1