COVID-19 and Anemia: What Do We Know So Far?

Hemoglobin, Год журнала: 2023, Номер 47(3), С. 122 - 129

Опубликована: Май 4, 2023

On 11 March 2020, the World Health Organization (WHO) declared novel SARS-CoV-2 virus responsible for causing COVID-19, a global pandemic. The primarily targets respiratory system but can also affect other systems, notably hematological pathologies. Anemia, common hematologic disorder, is characterized by reduced oxygen-carrying capacity of red blood cells. existing literature has suspected link between anemia and severe COVID-19 cases. Researchers are currently investigating long-term complications in anemic patients, as these may play crucial role predicting patient prognosis. Anemic individuals at higher risk experiencing infections due to several contributing pathophysiological mechanisms, including thrombotic, hemorrhagic, autoimmune etiologies. primary effect mechanisms decrease circulating hemoglobin levels, reducing oxygen availability This exacerbates hypoxia caused COVID-19-induced acute distress syndrome (ARDS). review offers comprehensive overview evidence regarding patients.

Язык: Английский

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Bacterial Community- and Hospital-Acquired Pneumonia in Patients with Critical COVID-19—A Prospective Monocentric Cohort Study

Antibiotics, Год журнала: 2024, Номер 13(2), С. 192 - 192

Опубликована: Фев. 16, 2024

The impact of bacterial pneumonia on patients with COVID-19 infection remains unclear. This prospective observational monocentric cohort study aims to determine the incidence community- and hospital-acquired (CAP HAP) its effect mortality in critically ill admitted intensive care unit (ICU) at University Hospital Olomouc between 1 November 2020 31 December 2022. secondary objectives this include identifying etiology CAP HAP exploring capabilities diagnostic tools, a focus inflammatory biomarkers. Data were collected from electronic information hospital system, encompassing biomarkers, microbiological findings, daily visit records, subsequently evaluated by ICU physicians clinical microbiologists. Out 171 suffering critical COVID-19, 46 (27%) had CAP, while 78 (46%) developed HAP. Critically who experienced exhibited higher compared without any infection, rates 38% 56% versus 11%, respectively. In most frequent causative agents chlamydophila mycoplasma; Enterobacterales, which multidrug-resistant 71% cases; Gram-negative non-fermenting rods; Staphylococcus aureus. Notably, no strains Streptococcus pneumoniae detected, only single strain each Haemophilus influenzae Moraxella catarrhalis was isolated. etiologic causing Enterobacterales rods. Based presented results, commonly used biochemical markers demonstrated poor predictive accuracy. To confirm diagnosis our patient cohort, it necessary assess initial values (particularly procalcitonin), consider signs indicative and/or rely positive findings. For diagnostics, appropriate conduct regular detailed examinations (with evaluating respiratory functions) closely monitor dynamics (preferably Interleukin-6).

Язык: Английский

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COVID-19 worsens quality of life in elderly heart failure patients: a clinical study

American Journal of Translational Research, Год журнала: 2025, Номер 17(2), С. 1416 - 1427

Опубликована: Янв. 1, 2025

The coronavirus disease 2019 (COVID-19) pandemic has significantly worsened the health and quality of life vulnerable populations, particularly elderly patients with heart failure. This study aimed to assess effect COVID-19 infection on in failure during pandemic. retrospective case-control included admitted Second People's Hospital Lanzhou between December 2022 2023, all whom were diagnosed ongoing All underwent nucleic acid testing upon admission. Among 96 who tested positive for 68 negative, multiple validated instruments used both physical mental life. These Minnesota Living Heart Failure Questionnaire (MLHFQ), 36-Item Short Form Health Survey component summary score (SF-36 PCS), 6-Minute Walking Test (6MWT), Geriatric Depression Scale-15 (GDS-15), Self-Rating Anxiety Scale (SAS) Total, Pittsburgh Sleep Quality Index (PSQI), Mini Nutritional Assessment-Short (MNA-SF), Fatigue, Resistance, Ambulation, Illness, Loss weight (FRAIL) Scale. exhibited lower blood pressure, SF-36 scores, 6MWT distances compared those negative (P<0.05). Additionally, COVID-19-positive group had higher MLHFQ older average age, a greater proportion NYHA class III-IV, more frequent electrolyte imbalances, elevated D-dimer, C-reactive protein (CRP), N-terminal pro-brain natriuretic peptide (NT-proBNP) levels, longer hospital stays also levels anxiety (SAS total), poorer sleep frailty (FRAIL Scale) their COVID-19-negative counterparts In addition, reported severe symptoms dyspnea fatigue Both age identified as significant factors negatively affecting this patient population. exacerbates decline highlights urgent need strengthened, comprehensive treatment targeted support group.

Язык: Английский

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Predictivity of the Prognostic Nutritional Index and Systemic Inflammation Index for All-Cause In-Hospital Mortality in Geriatric and Adult COVID-19 Inpatients

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(15), С. 4466 - 4466

Опубликована: Июль 30, 2024

Background: The prognostic nutritional index (PNI) and the systemic immune inflammation (SII) have been used as simple risk-stratification predictors for COVID-19 severity mortality in general population. However, associations between these indices might differ due to age-related changes such inflammaging several comorbid conditions older patients. Therefore, we aimed compare predictivity of PNI SII among hospitalized patients under 65 years old. Methods: Patients with from March 2020 December were retrospectively included. calculated hospital records within first 48 h after admission. Data evaluated whole group according age groups (≥65 < years). Receiver operating characteristic curves drawn evaluate SII. Results: Out 407 included this study, 48.4% (n = 197) patients, 51.6% 210) For mortality, area curve (AUC) adult (<65 years) was 0.706 (95% CI 0.583–0.828) (p 0.003) 0.697 0.567–0.827) 0.005), respectively. AUC 0.515 0.427–0.604) 0.739) 0.500 0.411–0.590) 0.993). Conclusions: accuracy predicting seemed be fair, but no association found geriatric study. varies groups.

Язык: Английский

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Analysis of Survival Modification by Furosemide Use in a Cohort of Hospitalized COVID-19 Patients with Severe or Critical Disease in Mexico: Due to Its Chemical Structure, Furosemide Is More than Just a Diuretic

Pharmaceutics, Год журнала: 2024, Номер 16(7), С. 920 - 920

Опубликована: Июль 10, 2024

In the ongoing fight against Coronavirus Disease 2019 (COVID-19), researchers are exploring potential treatments to improve outcomes, especially in severe cases. This includes investigating repurposing of existing medications, such as furosemide, which is widely available. study aimed evaluate impact furosemide on mortality rates among COVID-19 patients with or critical illness. We assessed a cohort 515 hospitalized adults who experienced high rate 43.9%. Using multivariate analysis adjusted risk ratios (AdRRs), factors like smoking (AdRR 2.48, 95% CI 1.53–4.01, p < 0.001), Pneumonia Severity Index (PSI) score 7.89, 5.82–10.70, mechanical ventilation 23.12, 17.28–30.92, neutrophilia 2.12, 1.52–2.95, and an elevated neutrophil-to-lymphocyte ratio (NLR) 2.39, 1.72–3.32, 0.001) were found increase risk. contrast, vaccination use associated reduced 0.58, = 0.001 0.60, 0.008; respectively). Furosemide showed pronounced survival benefit less disease (PSI 120) those not hemodialysis, significantly lower users (3.7% vs. 25.7%). A Kaplan–Meier confirmed longer better oxygenation levels treated furosemide. Furthermore, Structure–Activity Relationship revealed that furosemide’s sulfonamide groups may interact cytokine sites tumor necrosis factor-alpha (TNF-α) interleukin-6 (IL-6), potentially explaining its beneficial effects management. These findings suggest could be treatment option certain patient groups, enhancing improving oxygenation.

Язык: Английский

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Associations between COVID-19 and putative markers of neuroinflammation: A diffusion basis spectrum imaging study

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Июль 20, 2023

COVID-19 remains a significant international public health concern. Yet, the mechanisms through which symptomatology emerges remain poorly understood. While SARS-CoV-2 infection may induce prolonged inflammation within central nervous system, evidence primarily stems from limited small-scale case investigations. To address this gap, our study capitalized on longitudinal UK Biobank neuroimaging data acquired prior to and following testing (N=416 including n=224 cases; M

Язык: Английский

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Lactate dehydrogenase predicts disease progression outcome in COVID-19 patients treated with Azvudine

Frontiers in Cellular and Infection Microbiology, Год журнала: 2023, Номер 13

Опубликована: Окт. 18, 2023

Azvudine has been approved in China for the treatment of COVID-19 patients. Previous studies have suggested a correlation between high levels lactate dehydrogenase (LDH) and severity COVID-19. However, impact LDH patients receiving remains unclear.In this retrospective cohort study, we analyzed data 351 hospitalized who were consecutively treated with Azvudine, or without levels. The clinical features, strategies prognosis collected analyzed.Among (119 high-LDH levels), median age was 69 years (range 58-78), 213 (60.7%) male. Common symptoms included cough (86.0%), expectoration (73.5%), fever (69.8%), polypnea (47.6%) poor appetite (46.4%). Patients exhibited significantly elevated leucocyte neutrophil counts, level myocardial enzymes, as well higher inflammatory markers such interleukin-6, interleukin-10, procalcitonin, C reactive protein, ferritin, prolonged erythrocyte sedimentation rate upon admission. had rates corticosteroid therapy, non-invasive invasive mechanical ventilation, worsened death (2.5% vs. 0%). Cox proportional hazard model demonstrated that (adjusted ratio = 5.27; 95% confidence interval: 1.19, 14.50) associated more unfavorable composite disease progression outcome among after accounting potential confounding variables.High-LDH predict worse Azvudine.

Язык: Английский

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Associations between COVID-19 and putative markers of neuroinflammation: A diffusion basis spectrum imaging study

Brain Behavior & Immunity - Health, Год журнала: 2023, Номер 36, С. 100722 - 100722

Опубликована: Дек. 30, 2023

COVID-19 remains a significant international public health concern. Yet, the mechanisms through which symptomatology emerges remain poorly understood. While SARS-CoV-2 infection may induce prolonged inflammation within central nervous system, evidence primarily stems from limited small-scale case investigations. To address this gap, our study capitalized on longitudinal UK Biobank neuroimaging data acquired prior to and following testing (N = 416 including n 224 cases; Mage 58.6). Putative neuroinflammation was assessed in gray matter structures white tracts using non-invasive Diffusion Basis Spectrum Imaging (DBSI), estimates inflammation-related cellularity (DBSI-restricted fraction; DBSI-RF) vasogenic edema (DBSI-hindered DBSI-HF).We hypothesized that status would be associated with increases DBSI markers after accounting for potential confound (age, sex, race, body mass index, smoking frequency, acquisition interval) multiple testing. not significantly DBSI-RF (|β|'s < 0.28, pFDR >0.05), but greater DBSI-HF left pre- post-central gyri right middle frontal gyrus (β′s > 0.3, all 0.03). Intriguingly, brain areas exhibiting increased putative had previously been linked COVID-19-related functional structural alterations, whereas regions displaying subtle differences between cases controls included or functionally connected olfactory network, has implicated psychopathology. Nevertheless, might have captured acute transitory neuroinflammatory effects infection, possibly due symptom resolution before imaging scan. Future research is warranted explore time- symptom-dependent relationship COVID-19.

Язык: Английский

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Analysis and interpretation of Coronavirus infection children’s incidence, contributing factors, risks of complications and their relationship

Wiadomości Lekarskie, Год журнала: 2024, Номер 77(3), С. 484 - 490

Опубликована: Янв. 1, 2024

Aim: To study and investigate the incidence of Coronavirus infection in children, course disease, risks complications their interrelationships.

Язык: Английский

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Unveiling Immunological and Hematological Markers in COVID-19: Insights from a Clinical Study

Viral Immunology, Год журнала: 2024, Номер unknown

Опубликована: Окт. 2, 2024

The COVID-19 pandemic has affected the global health system and economies largely. Therefore, knowledge about clinical laboratory profiles of patients with would help in management prognosis disease. immunological hematological indices have emerged as critical determinants for severity disease prognosis; however, association is clouded. present study aimed to characterize correlation severity. included 1,019 polymerase chain reaction (PCR)-confirmed who were classified into serious nonserious groups, considering criteria. Clinical investigations hematological, biochemical, parameters regarding leukocyte counts, hemoglobin levels, inflammatory markers. Our analysis differences between indicates that cases reflected elevated levels pro-inflammatory markers such lactate dehydrogenase, C-reactive protein (CRP), D-dimer, ferritin, representing immune dysregulation systemic inflammation. Furthermore, cases, discrepancies had also been noticed many than ones, which contained count level. Additionally, CRP, blood urea nitrogen, alanine transaminase, albumin could be independent predictors by multivariate logistic regression analysis. Cutoff values these biomarkers defined receiver operating characteristic curve defining optimal risk stratification prognostication. current investigation provides a comprehensive understanding severity, refining decision-making therapeutic interventions improve patient outcomes.

Язык: Английский

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