Pathology - Research and Practice, Год журнала: 2024, Номер 266, С. 155747 - 155747
Опубликована: Ноя. 28, 2024
Язык: Английский
Journal of Medical Virology, Год журнала: 2024, Номер 96(4)
Опубликована: Апрель 1, 2024
Abstract Exosomes play a crucial role in intercellular communication and have emerged as significant vehicles for transporting disease‐specific biomarkers. This feature provides profound insights into the progression of diseases responses patients to treatments. For example, leukemia, exosomes convey critical information through carriage specific proteins nucleic acids. In case human papillomavirus (HPV)‐mediated cervical cancer, are particularly useful noninvasive detection they transport high‐risk HPV DNA biomolecules, which can be indicators disease. Despite their vast potential, there several challenges associated with use medical diagnostics. These include inherent heterogeneity, need enhanced sensitivity methods, establishment standardization protocols, requirement cost‐effective scalability application. Addressing these is effective implementation exosome‐based Future research development geared towards overcoming obstacles. Efforts concentrated on refining processes biomarker discovery, establishing comprehensive regulatory frameworks, developing convenient point‐of‐care devices, exploring methods multimodal detection, conducting extensive clinical trials. The ultimate goal efforts inaugurate new era precision diagnostics within healthcare. would significantly improve patient outcomes reduce burden such leukemia HPV‐mediated cancer. integration cutting‐edge technology holds promise reinforcing foundations healthcare, leading diagnostic accuracy, better disease monitoring, more personalized therapeutic approaches.
Язык: Английский
Процитировано
5
ACS Applied Bio Materials, Год журнала: 2024, Номер 7(11), С. 7076 - 7087
Опубликована: Ноя. 4, 2024
Extracellular vesicles (EVs) are cellular communication molecules and classified into three major subpopulations, such as microvesicles, apoptotic bodies, exosomes. Among these, exosomes-based cancer research is a cutting-edge investigation approach to understanding. During progression , tumor-derived exosomes can reprogram the system promote cancer. Circulating in body fluids blood, plasma, serum, saliva, CSF, sweat, tears play key role identifying diagnostic prognostic biomarkers. Diverse therapeutic sources of including stem cells, plants, immune etc. exhibit significant cancer-healing properties. Although cancer-targeting immunotherapy an effective strategy, it has limitations toxicity, high costs. In comparison, cell-derived cell-free for treatment advantages like less biocompatibility, reduced immunogenicity, efficient, target-specific development. This review highlights signature treatment.
Язык: Английский
Процитировано
4
Gene, Год журнала: 2025, Номер unknown, С. 149296 - 149296
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160915 - 160915
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Clinica Chimica Acta, Год журнала: 2025, Номер 571, С. 120243 - 120243
Опубликована: Март 14, 2025
Язык: Английский
Процитировано
0
The Journal of Liquid Biopsy, Год журнала: 2024, Номер 3, С. 100137 - 100137
Опубликована: Янв. 3, 2024
Cancer is the leading cause of death worldwide. The most complicated fact about this disease early diagnosis. Treatment at advanced stages extremely challenging. We need an cancer detection method. Nanotechnology-based liquid biopsy efficient platform for health crisis. Several modifications to method ushered in a new era biopsy. present article addresses transforming signature nanobiotechnology on techniques (it explores its advantages and limitations).
Язык: Английский
Процитировано
2
The Journal of Liquid Biopsy, Год журнала: 2024, Номер 4, С. 100144 - 100144
Опубликована: Фев. 5, 2024
Cancer drugs and therapeutics resistance are a complicated domain of cancer treatment. Extracellular vesicles (EVs) based investigation reveals several concepts about cancer. EVs associated with cellular communication. Its bioactive molecular transportation reprograms activity. Exosomes an exciting subpopulation work as masterminds in development progression. Studies over the past decade have elucidated that exosomes play vital role intercellular communication within tumor microenvironment (TME), influencing multiple events such hypoxia-induced epithelial-mesenchymal transition (EMT), stemness, angiogenesis, metastasis. Tumor-derived (TEXs) development. This article focuses on understanding exosome biology its implications drug resistance, exosome-based liquid biopsy application therapeutic detection, limitations, future orientation this domain.
Язык: Английский
Процитировано
1
Advances in Cancer Biology - Metastasis, Год журнала: 2024, Номер 11, С. 100123 - 100123
Опубликована: Июль 8, 2024
Colorectal cancer is one of the most prevalent cancers worldwide. An increasing number cases around globe are raising concerns for life quality and survival. Various factors including genetic drivers have been extensively studied regarding disease risk, progression, metastasis. However, signaling mechanisms haven't yet. therapeutic methods established in combating disease, mesenchymal stem cells come up as a crucial cell-based strategy. Mesenchymal regarded potential targets various types due to their immune-modulatory functions. They can be isolated from many body tissues bone marrow, peripheral blood, umbilical cord, adipose tissue. Exosomes derived reported affect expression certain proteins associated with colorectal cancer. The current review highlights exosomes treating by causing cytotoxicity apoptosis. Further, T-cell mediated modulation helps reduce cellular proliferation cells.
Язык: Английский
Процитировано
1
The Journal of Liquid Biopsy, Год журнала: 2024, Номер 6, С. 100162 - 100162
Опубликована: Июль 14, 2024
Язык: Английский
Процитировано
1
The Journal of Liquid Biopsy, Год журнала: 2023, Номер 3, С. 100134 - 100134
Опубликована: Дек. 16, 2023
Exosomes, small extracellular vesicles of endocytic origin, have emerged as pivotal mediators in intercellular communication, driving transformative advancements across diverse fields biology and medicine. This comprehensive review delves into the multifaceted roles exosomes health disease, elucidating their biogenesis, cargo composition, far-reaching implications. secreted by virtually all cell types, encapsulate a comprising proteins, lipids, nucleic acids, reflecting cellular origin. Their molecular modulates processes, facilitating complex signalling cascades contributing to pathogenesis various diseases, including cancer, neurodegenerative disorders, infectious diseases. In serve messengers tumorigenesis metastasis, orchestrating critical events within tumor microenvironment. Furthermore, participate drug resistance mechanisms, presenting significant challenges cancer therapy. The diagnostic potential exosomes, particularly context liquid biopsy, is underscored presence biofluids. offers non-invasive disease monitoring biomarker discovery, revolutionizing early detection strategies. Additionally, gained recognition therapeutic vehicles, holding promise for targeted delivery, immunomodulation, regenerative comprehensively explores ever-expanding landscape exosome biology, emphasizing disease. It underscores biopsy-based diagnostics therapeutics while acknowledging complexities that lie ahead harnessing full clinical utility.
Язык: Английский
Процитировано
3