Recent Advances in 3D Printing of Smart Scaffolds for Bone Tissue Engineering and Regeneration

Advanced Materials, Год журнала: 2024, Номер 36(34)

Опубликована: Июнь 11, 2024

The repair and functional reconstruction of bone defects resulting from severe trauma, surgical resection, degenerative disease, congenital malformation pose significant clinical challenges. Bone tissue engineering (BTE) holds immense potential in treating these defects, without incurring prevalent complications associated with conventional autologous or allogeneic grafts. 3D printing technology enables control over architectural structures at multiple length scales has been extensively employed to process biomimetic scaffolds for BTE. In contrast inert grafts, next-generation smart possess a remarkable ability mimic the dynamic nature native extracellular matrix (ECM), thereby facilitating regeneration. Additionally, they can generate tailored controllable therapeutic effects, such as antibacterial antitumor properties, response exogenous and/or endogenous stimuli. This review provides comprehensive assessment progress 3D-printed BTE applications. It begins an introduction physiology, followed by overview technologies utilized scaffolds. Notable advances various stimuli-responsive strategies, efficacy, applications are discussed. Finally, highlights existing challenges development implementation scaffolds, well emerging this field.

Язык: Английский

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Study on the synergistic effect of second phases and product films to significantly improve the corrosion resistance of Mg- Gd-Y-Nd alloy

Corrosion Science, Год журнала: 2024, Номер 237, С. 112304 - 112304

Опубликована: Июль 20, 2024

Язык: Английский

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Impact of Copper addition and Calcium phosphate coating on Mg Alloys for biomedical applications

Results in Engineering, Год журнала: 2025, Номер unknown, С. 104986 - 104986

Опубликована: Апрель 1, 2025

Язык: Английский

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8High strength and high ductility combination of biodegradable high-purity magnesium fabricated by forward extrusion and extrusion-shear process

Journal of Alloys and Compounds, Год журнала: 2025, Номер unknown, С. 180388 - 180388

Опубликована: Апрель 1, 2025

Язык: Английский

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Review of progress on fabrication technology of Mg matrix composites

Journal of Magnesium and Alloys, Год журнала: 2024, Номер unknown

Опубликована: Дек. 1, 2024

Язык: Английский

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Effects of Yb element on microstructure and mechanical properties of high-strength Mg-Sm-Gd(-Yb)-Zr extruded alloys

Journal of Magnesium and Alloys, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

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Multifunctional zinc oxide loaded stearic acid surfaces on biodegradable magnesium WE43 alloy with hydrophobic, self-cleaning and biocompatible attributes

Applied Surface Science, Год журнала: 2024, Номер 680, С. 161455 - 161455

Опубликована: Окт. 9, 2024

Язык: Английский

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Rare-Earth based magnesium alloys as a potential biomaterial for the future

Journal of Magnesium and Alloys, Год журнала: 2024, Номер 12(10), С. 3841 - 3897

Опубликована: Окт. 1, 2024

Язык: Английский

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Biomaterials for bone tissue engineering: achievements to date and future directions

Biomedical Materials, Год журнала: 2024, Номер 20(1), С. 012001 - 012001

Опубликована: Ноя. 22, 2024

Abstract Advancement in medicine and technology has resulted into prevention of countless deaths increased life span. However, it is important to note that, the modern lifestyle altered food habits, witnessed life-style stresses road accidents leading several health complications one primary victims bone health. More often than ever, healthcare professionals encounter cases massive fracture, loss generation critical sized defects. Surgical interventions, through use grafting techniques are necessary such cases. Natural grafts (allografts, autografts xenografts) however, have major drawbacks terms delayed rehabilitation, lack appropriate donors, infection morbidity that shifted focus investigators direction synthetic grafts. By employing biomaterials based on tissue engineering (BTE), provide a more biologically acceptable approach establishing phases healing. In BTE, various materials utilized support enhance regeneration. Biodegradable polymers like poly-(lactic acid), poly-(glycolic poly-( ϵ -caprolactone) commonly used for their customizable mechanical properties ability degrade over time, allowing natural growth. PEG employed hydrogels promote cell adhesion Ceramics, as hydroxyapatite beta-tricalcium phosphate ( β -TCP) mimic mineral attachment, with -TCP gradually resorbing new forms. Composite materials, including polymer-ceramic polymer-glasses, combine benefits both ceramics/glasses offer enhanced biological properties. collagen, gelatin, chitosan matrix attachment formation, also offering antimicrobial Hybrid decellularized retain structure factors, while functionalized scaffolds incorporate growth factors or bioactive molecules further stimulate healing integration. The current review article provides insights could yield revolutionary improvements orthopedic medical fields. introduction section this focuses statistical information requirements globally its impact economy. later section, anatomy human bone, defects diseases pertaining limitations were detailed. Biopolymers, bioceramics, biometals-based discussed depth sections followed. then concludes summary addressing trends future prospects potential transplants.

Язык: Английский

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Recent advances in magnesium alloys for biomedical applications: A review

Materials Today Communications, Год журнала: 2024, Номер 42, С. 111239 - 111239

Опубликована: Дек. 9, 2024

Язык: Английский

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