Chemistry - Methods, Год журнала: 2025, Номер unknown

Опубликована: Май 5, 2025

Dissolution dynamic nuclear polarization (dDNP) has emerged as a powerful technique to address the inherent sensitivity limitations in magnetic resonance imaging and spectroscopy. The relies on use of stable paramagnetic polarizing agents that act source hyperpolarization but unfortunately, their presence contaminates sample significantly enhances relaxation hyperpolarized solutions. In last decade, novel formulations have been proposed combat this issue, including silica‐based hybrid solids (HYPSO), which enabled production contamination‐free hyperpolarization. Herein, new generation with pore diameters increased from 4 up 28 nm is presented. Compared previously described HYPSOs smaller sizes nm, larger pores ultimately achieve ambitious contradictory goals 1) providing rapid high solid‐state improving cross‐polarization efficiency, while 2) decreasing losses upon melting, transfer, filtration, 3) reducing overall concentration agent by factor 2. These HYPSO materials can be used virtually any existing dDNP settings without modification, apart sole addition an in‐line commercial filter retain powder dissolution transfer.

Язык: Английский