Zero- to ultralow-field nuclear magnetic resonance
Progress in Nuclear Magnetic Resonance Spectroscopy,
Год журнала:
2025,
Номер
unknown, С. 101558 - 101558
Опубликована: Фев. 1, 2025
Язык: Английский
Live magnetic observation of parahydrogen hyperpolarization dynamics
Proceedings of the National Academy of Sciences,
Год журнала:
2024,
Номер
121(43)
Опубликована: Окт. 15, 2024
Hyperpolarized
nuclear
spins
in
molecules
exhibit
high
magnetization
that
is
unachievable
by
classical
polarization
techniques,
making
them
widely
used
as
sensors
physics,
chemistry,
and
medicine.
The
state
of
a
hyperpolarized
material,
however,
typically
only
studied
indirectly
with
partial
destruction
magnetization,
due
to
the
nature
conventional
detection
resonant-pickup
NMR
spectroscopy
or
imaging.
Here,
we
establish
atomic
magnetometers
sub-pT
sensitivity
an
alternative
modality
detect
real
time
complex
dynamics
materials
without
disturbing
interrupting
magnetogenesis
process.
As
example
are
impossible
means,
examine
parahydrogen-induced
1
H
13
C
during
adiabatic
eigenbasis
transformations
at
μ
T-field
avoided
crossings.
Continuous
but
nondestructive
magnetometry
reveals
previously
unseen
spin
dynamics,
fidelity
limits,
backaction
effects.
second
example,
apply
observe
chemical-exchange-driven
hyperpolarization
[1–
C]-pyruvate—the
most
important
tracer
for
clinical
metabolic
approach
can
be
readily
combined
other
high-sensitivity
applicable
broader
range
general
observation
scenarios
involving
production,
transport,
systems
interaction
compounds.
Язык: Английский
Open-source compact time-domain hydrogen (1H) NMR System for Field Deployment
HardwareX,
Год журнала:
2025,
Номер
unknown, С. e00651 - e00651
Опубликована: Апрель 1, 2025
Язык: Английский
Polarization losses from the nonadiabatic passage of hyperpolarized solutions through metallic components
Journal of Magnetic Resonance Open,
Год журнала:
2024,
Номер
18, С. 100144 - 100144
Опубликована: Янв. 13, 2024
From
complex-mixture
analysis
to
in
vivo
molecular
imaging,
applications
of
liquid-state
nuclear
spin
hyperpolarization
have
expanded
widely
over
recent
years.
In
most
cases,
hyperpolarized
solutions
are
generated
ex
situ
and
transported
from
the
polarization
instrument
measurement
device.
The
sample
usually
survives
this
transport,
since
changes
magnetic
fields
that
external
typically
adiabatic
(slow)
with
respect
internal
dynamics.
passage
polarized
samples
through
weakly
components
such
as
stainless
steel
syringe
needles
ferrules
is
not
always
adiabatic,
which
can
lead
near-complete
destruction
magnetization.
To
avoid
effect
becoming
"folklore"
field
NMR,
we
present
a
systematic
investigation
highlight
problem
investigate
possible
solutions.
Experiments
were
carried
out
on:
(i)
dissolution-DNP-polarized
[1-13C]pyruvate
NMR
detection
at
1.4
T,
(ii)
1.5-T-polarized
H2O
2.5
μT.
We
show
degree
adiabaticity
passing
metal
parts
intrinsically
unpredictable,
likely
depending
on
many
factors
solution
flow
rate,
remanent
ferromagnetism
metal,
species.
However,
magnetization
effects
be
suppressed
by
application
an
order
0.1–10
mT.
Язык: Английский
DETECTION OF METRONIDAZOLE AND FAMPRIDINE BY NMR AT ZERO AND ULTRALOW MAGNETIC FIELD
Журнал Экспериментальной и Теоретической Физики,
Год журнала:
2024,
Номер
166(4), С. 566 - 570
Опубликована: Ноя. 1, 2024
Язык: Английский
Automated test apparatus for bench-testing the magnetic field homogeneity of NMR transceiver coils
Journal of Magnetic Resonance Open,
Год журнала:
2023,
Номер
18, С. 100142 - 100142
Опубликована: Дек. 21, 2023
We
describe
an
automated
hands-off
bench
testing
method
for
measuring
the
magnetic
field
profile
of
transceiver
coils
nuclear
resonance
(NMR).
The
scattering
parameter
(S-parameter)
data
is
measured
using
a
portable
network
analyzer,
and
results
are
automatically
exported
to
computer
plotting
viewing.
This
assay
dramatically
reduces
time
needed
measure
(B1)
homogeneity
coil
while
also
improving
accuracy
relative
manual
operation.
Here,
we
demonstrate
on
saddle
solution-state
NMR
probe
in
comparison
profiles
obtained
spectroscopy
measurements.
axial
radial
variable-pitch
solenoid.
Язык: Английский
Optically detected nuclear magnetic resonance above and far below earth's magnetic field: spin dynamics and relaxation in unconventional regimes
Опубликована: Фев. 15, 2024
(English)
This
thesis
describes
theoretical
background,
simulations,
experimental
apparatus
and
measurements
of
nuclear
spin
dynamics
via
optically
pumped
magnetometers
in
unconventional
magnetic
field
regimes.
It
is
divided
into
four
parts:
Magnetometry,
Nuclear
Magnetic
Resonance
Spectroscopy,
Relaxation
Dispersion,
Spin
Control,
each
looking
at
different
aspects
this
topic.
The
magnetometry
section
how
through
integration
techniques
from
DC
spin-exchange
relaxation-free
rf
magnetometers,
a
widely
tunable
magnetometer
developed
that
offers
nearly
flat
response
up
to
few
kHz
with
sensitivity
less
than
20
fT
√Hz.
Within
range,
it
surpasses
the
capabilities
inductive
detection
methods
eliminates
necessity
for
cryogenic
temperatures
are
required
superconducting
quantum
interference
devices
(SQUIDs).
subsequent
part
employs
conducting
resonance
spectroscopy
experiments
involving
coupled
systems.
A
comprehensive
analysis
undertaken
ascertain
optimal
yields
most
precise
determination
J-coupling
constant.
shown
some
systems
ultra-low
regime
advantages
compared
zero-
high-field
regime.
key
factor
choosing
relaxation’s
strong
dependency,
explored
thesis’s
third
part.
thoroughly
examines
subject
discussing
long-lived
coherences
impact
long
correlations
molecular
dynamics.
experimentally
investigates
by
adapting
established
fast-field
cycling
method
fields
combining
optical
detection.
thesis’
s
final
focuses
on
enhancing
manipulation
advanced
ensure
selective,
efficient,
accurate,
fault-tolerant
control.
Ultra-low
possess
unique
attributes,
making
even
basic
like
spin-selective
resonant
pulses
challenging
implement.
To
address
this,
novel
concepts
were
devised,
enabling
effective
control
rivaling
or
surpassing
counterparts.
efficiency
these
improved
pulse
sequences
demonstrated
dynamical
decoupling,
polarimetry,
spectral
filtering
experiments.
(Català)
Aquesta
tesi
doctoral
descriu
la
teoria,
simulacions,
aparell
i
mesuraments
de
dinàmiques
espín
per
mitjà
magnetòmetres
bombeig
òptic
en
règims
magnètics
no
convencionals.
està
dividida
quatre
magnetometria,
espectroscòpia
ressonància
magnètica
nuclear,
dispersió
relaxació
nuclear.
La
secció
magnetometria
com,
mitjançant
integració
les
tècniques
d’intercanvi
lliure
RF,
s’ha
desenvolupat
un
magnetòmetre
àmpliament
ajustable
que
ofereix
una
resposta
gairebé
plana
des
fins
uns
pocs
amb
sensibilitat
menys
En
aquest
rang,
sobrepassa
capacitats
mètodes
detecció
inductiva
elimina
necessitat
criogèniques
necessàries
aparells
superconductors
d'interferència
quàntica
o
SQUIDs
(per
sigles
anglès).
següent
s'empra
el
realitzar
d'espectroscòpia
sistemes
espines
nuclears
acoblats.
Es
fa
anàlisi
exhaustiva
trobar
camp
magnètic
dóna
determinació
més
precisa
constant
J
d'acoblament.
demostra
alguns
règim
camps
ultra
baixos
ofereixen
avantatges
quan
es
comparen
els
zero
y
alt
règim.
Un
clau
triar
és
forta
dependència
l'espín
camp.
s'explora
tercera
d'aquesta
al
rang
convencional
baixos,
discussió
sobre
coherències
persistents
llarga
vida
l'impacte
correlacions
esteses
moleculars.
Aquest
estudi
realitza
experimentalment
adaptant
mètode
establert
rotació
ràpida
(fast
cycling)
combinant-ho
òptica.
s'enfoca
millorar
manipulació
d'espín
avançats
asseguren
selectiu,
eficient,
exacte
prova
d'errors.
Els
tenen
atributs
únics
fan
tot
bàsiques
com
polsos
ressonants
selectius
siguin
difícils
d'implementar.
Per
resoldre
això,
s'han
nous
conceptes
permeten
efectiu
similars
millors
contraparts
alts.
L'eficàcia
d'aquestes
seqüències
millorades
desacoblament
dinàmic,
polarimetria
filtratge
espectral.
Selective enhancement of 1H signal from water and oil in porous media at low field with Overhauser DNP
Journal of Magnetic Resonance,
Год журнала:
2024,
Номер
368, С. 107793 - 107793
Опубликована: Окт. 31, 2024
In
porous
media
MR
studies,
discriminating
between
oil
and
water
presents
a
challenge
because
lifetimes
are
often
similar
spectra
overlap.
Low
saturations
might
suggest
an
experimental
strategy
of
increasing
the
static
field
for
increased
sensitivity,
but
susceptibility
effects
exacerbated
at
higher
field.
Overhauser
dynamic
nuclear
polarization,
effective
low
field,
was
employed
with
oil-soluble
nitroxide
to
selectively
enhance
signals.
We
employ
home-built
2
MHz
ceramic
magnet
achieve
selective
enhancement
oil,
in
bulk,
rock
core.
For
imaging,
we
705
kHz
4
gauss/cm
constant
gradient
configuration
image
hyperpolarized
signal.
A
core
flooding
experiment
undertaken
highlight
advantages
enhancement.
simple
phase
cycling
technique
may
be
cancel
thermally
polarized
Язык: Английский