Brazilian Dental Journal,
Год журнала:
2022,
Номер
33(1), С. 1 - 12
Опубликована: Фев. 1, 2022
Abstract
Dental
implants
made
of
titanium
(Ti)
material
is
recognized
as
the
leading
treatment
option
for
edentulous
patients’
rehabilitation,
showing
a
high
success
rate
and
clinical
longevity.
However,
dental
implant
surface
acts
platform
microbial
adhesion
accumulation
once
exposed
to
oral
cavity.
Biofilm
formation
on
surfaces
has
been
considered
main
etiologic
factor
induce
inflammatory
diseases,
known
peri-implant
mucositis
peri-implantitis;
latter
being
key
reason
late
failure.
Different
factors,
such
biofilm
matrix
production,
source
carbohydrate
exposure,
cross-kingdom
interactions,
have
encouraged
increased
implants,
microbiological
community
shift
from
healthy
pathogenic
state,
increasing
inflammation
favoring
tissue
damage.
These
factors
combined
with
spatial
organization
biofilms,
reduced
antimicrobial
susceptibility,
complex
composition,
irregular
topography
hamper
control
killing.
In
spite
well-known
etiology,
there
still
no
consensus
regarding
best
protocol
treat
disease.
this
sense,
different
coatings
Ti
treatments
proposed
in
order
reduce
loads
polymicrobial
infections
implantable
devices.
Therefore,
critical
review
aims
discuss
current
evidence
central
related
pathogenesis
process
implant-related
infections.
Moreover,
potential
modifications
anti-biofilm
properties
devices
discussed
shed
light
further
promising
strategies
peri-implantitis.
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 19, 2025
Biomedical
materials
are
of
great
significance
for
preventing
and
treating
major
diseases
protecting
human
health.
At
present,
more
stringent
requirements
have
been
put
forward
the
preparation
methods
dimension
control
biomedical
based
on
urgent
demand
high-performance
materials,
especially
existence
various
physiological
size
thresholds
in
vitro/in
vivo.
Microfluidic
platforms
break
limitations
traditional
micro-/nanomaterial
synthesis,
which
provide
a
miniaturized
highly
controlled
environment
size-dependent
biomaterials.
In
this
review,
basic
conceptions
technical
characteristics
microfluidics
first
described.
Then
syntheses
with
different
dimensions
(0D,
1D,
2D,
3D)
driven
by
systematically
summarized.
Meanwhile,
applications
microfluidics-driven
including
diagnosis,
anti-inflammatory,
drug
delivery,
antibacterial,
disease
therapy,
discussed.
Furthermore,
challenges
developments
research
field
further
proposed.
This
work
is
expected
to
facilitate
convergence
between
bioscience
engineering
communities
continue
contribute
emerging
field.
ACS Applied Materials & Interfaces,
Год журнала:
2021,
Номер
13(38), С. 45191 - 45200
Опубликована: Сен. 14, 2021
Pathogenic
biofilms
formed
on
the
surfaces
of
implantable
medical
devices
and
materials
pose
an
urgent
global
healthcare
problem.
Although
conventional
antibacterial
based
bacteria-repelling
or
bacteria-killing
strategies
can
delay
biofilm
formation
to
some
extent,
they
usually
fail
in
long-term
applications,
it
remains
challenging
eradicate
recalcitrant
once
are
established
mature.
From
viewpoint
microbiology,
a
promising
strategy
may
be
target
middle
stage
including
main
biological
processes
involved
development.
In
this
work,
dual-functional
antibiofilm
surface
is
developed
copolymer
brushes
2-hydroxyethyl
methacrylate
(HEMA)
3-(acrylamido)phenylboronic
acid
(APBA),
with
quercetin
(Qe,
natural
molecule)
incorporated
via
acid-responsive
boronate
ester
bonds.
Due
antifouling
properties
hydrophilic
poly(HEMA)
component,
resulting
able
suppress
bacterial
adhesion
aggregation
early
stages
contact.
A
few
bacteria
eventually
break
through
protection
anti-adhesion
layer
leading
colonization.
response
decrease
pH
microenvironment,
could
then
release
Qe
interfere
microbiological
related
formation.
Compared
bactericidal
anti-adhesive
surfaces,
showed
significantly
improved
performance
prevent
involving
both
Gram-negative
Pseudomonas
aeruginosa
Gram-positive
Staphylococcus
aureus
for
up
3
days.
addition,
negligibly
cytotoxic,
thereby
avoiding
possible
harmful
effects
adjacent
normal
cells
risk
resistance.
This
design
approach
addresses
different
formation,
(in
accordance
growth
process
biofilm)
allows
sequential
activation
functions
without
compromising
viability
cells.
simple
reliable
solution
thus
provided
problems
associated
various
biomedical
applications.
Tissue Engineering Part A,
Год журнала:
2022,
Номер
28(11-12), С. 555 - 572
Опубликована: Март 30, 2022
Dental
implants
represent
an
illustrative
example
of
successful
medical
devices
used
in
increasing
numbers
to
aid
(partly)
edentulous
patients.
Particularly
spite
the
percutaneous
nature
dental
implant
systems,
their
clinical
success
is
remarkable.
This
at
least
partly
related
effective
surface
treatment
artificial
root,
providing
appropriate
physicochemical
properties
achieve
osseointegration.
The
demographic
changes
world,
however,
with
a
rapidly
life
expectancy
and
increase
patients
suffering
from
comorbidities
that
affect
wound
healing
bone
metabolism,
make
performance
requires
continuous
improvement.
An
additional
factor
endangering
peri-implantitis,
which
affects
both
soft
hard
tissue
interactions
implants.
In
this
study,
we
shed
light
on
optimization
surfaces
through
engineering.
Depending
region
along
different
are
required
optimize
prevailing
response
facilitate
osseointegration,
improve
attachment,
exert
antibacterial
efficacy.
As
such,
engineering
represents
important
tool
for
assuring
continued
future
Impact
Statement
common
modality
nowadays
replacement
lost
teeth
or
fixation
prosthetic
devices.
review
provides
detailed
overview
role
components
responses
regions
root.
steering
immunomodulatory
processes,
facilitating
rendering
efficacy
(at
root
abutment
region)
described.
finally
concludes
warrant
will
remain
proof
more
challenging
applications,
including
aging
patient
population
metabolism
healing.
Brazilian Dental Journal,
Год журнала:
2022,
Номер
33(1), С. 1 - 12
Опубликована: Фев. 1, 2022
Abstract
Dental
implants
made
of
titanium
(Ti)
material
is
recognized
as
the
leading
treatment
option
for
edentulous
patients’
rehabilitation,
showing
a
high
success
rate
and
clinical
longevity.
However,
dental
implant
surface
acts
platform
microbial
adhesion
accumulation
once
exposed
to
oral
cavity.
Biofilm
formation
on
surfaces
has
been
considered
main
etiologic
factor
induce
inflammatory
diseases,
known
peri-implant
mucositis
peri-implantitis;
latter
being
key
reason
late
failure.
Different
factors,
such
biofilm
matrix
production,
source
carbohydrate
exposure,
cross-kingdom
interactions,
have
encouraged
increased
implants,
microbiological
community
shift
from
healthy
pathogenic
state,
increasing
inflammation
favoring
tissue
damage.
These
factors
combined
with
spatial
organization
biofilms,
reduced
antimicrobial
susceptibility,
complex
composition,
irregular
topography
hamper
control
killing.
In
spite
well-known
etiology,
there
still
no
consensus
regarding
best
protocol
treat
disease.
this
sense,
different
coatings
Ti
treatments
proposed
in
order
reduce
loads
polymicrobial
infections
implantable
devices.
Therefore,
critical
review
aims
discuss
current
evidence
central
related
pathogenesis
process
implant-related
infections.
Moreover,
potential
modifications
anti-biofilm
properties
devices
discussed
shed
light
further
promising
strategies
peri-implantitis.
