Antibacterial coatings on orthopedic implants

Materials Today Bio, Год журнала: 2023, Номер 19, С. 100586 - 100586

Опубликована: Фев. 15, 2023

With the aging of population and rapid improvement public health medical level in recent years, people have had an increasing demand for orthopedic implants. However, premature implant failure postoperative complications frequently occur due to implant-related infections, which not only increase social economic burden, but also greatly affect patient's quality life, finally restraining clinical use Antibacterial coatings, as effective strategy solve above problems, been extensively studied motivated development novel strategies optimize implant. In this paper, a variety antibacterial coatings recently developed implants were briefly reviewed, with focus on synergistic multi-mechanism multi-functional smart that are more potential use, thereby providing theoretical references further fabrication high-performance satisfying complex needs.

Язык: Английский

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Chitosan enhanced the stability and antibiofilm activity of self-propelled Prussian blue micromotor

Carbohydrate Polymers, Год журнала: 2022, Номер 299, С. 120134 - 120134

Опубликована: Сен. 21, 2022

Язык: Английский

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Surface modification of titanium substrate via combining photothermal therapy and quorum-sensing-inhibition strategy for improving osseointegration and treating biofilm-associated bacterial infection

Bioactive Materials, Год журнала: 2022, Номер 18, С. 228 - 241

Опубликована: Март 16, 2022

Язык: Английский

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From Antibacterial to Antibiofilm Targeting: An Emerging Paradigm Shift in the Development of Quaternary Ammonium Compounds (QACs)

ACS Infectious Diseases, Год журнала: 2023, Номер 9(3), С. 394 - 422

Опубликована: Фев. 15, 2023

In a previous development stage, mostly individual antibacterial activity was target in the optimization of biologically active compounds and antiseptic agents. Although this targeting is still valuable, new trend has appeared since discovery superhigh resistance bacterial cells upon their aggregation into groups. Indeed, it now well established that great majority pathogenic germs are found environment as surface-associated microbial communities called biofilms. The protective properties biofilms resistance, even to high concentrations biocides, cause many chronic infections medical settings lead serious economic losses various areas. A paradigm shift from also affecting more complex cellular frameworks taking place involves multiple strategies for combating with effective at different stages microbiome formation. Quaternary ammonium (QACs) play key role these treatments prophylactic techniques on basis both use agents combination technologies. review, we summarize literature data effectiveness using commercially available newly synthesized QACs, synergistic treatment based them. As an important focus, developing applying antimicrobial coatings prevent formation surfaces over time discussed. information analyzed review will be useful researchers engineers working fields, including generation applied materials; understanding biofilm surface growth; conducting research medical, pharmaceutical, materials sciences. regular studies widely conducted, promising evaluate antibiofilm comprehensive study order meet current requirements highly needed practical applications.

Язык: Английский

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Bi-functional quercetin/copper nanoparticles integrating bactericidal and anti-quorum sensing properties for preventing the formation of biofilms

Biomaterials Science, Год журнала: 2024, Номер 12(7), С. 1788 - 1800

Опубликована: Янв. 1, 2024

A bi-functional antibiofilm nanoplatform was developed based on a complex of quercetin and copper integrating bactericidal anti-quorum sensing properties.

Язык: Английский

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Medical Device-Associated Infections Caused by Biofilm-Forming Microbial Pathogens and Controlling Strategies

Antibiotics, Год журнала: 2024, Номер 13(7), С. 623 - 623

Опубликована: Июль 4, 2024

Hospital-acquired infections, also known as nosocomial include bloodstream surgical site skin and soft tissue respiratory tract urinary infections. According to reports, Gram-positive Gram-negative pathogenic bacteria account for up 70% of infections in intensive care unit (ICU) patients. Biofilm production is a main virulence mechanism distinguishing feature bacterial pathogens. Most pathogens develop biofilms at the solid-liquid air-liquid interfaces. An essential requirement biofilm presence conditioning film. A film provides first surface on which can adhere fosters growth by creating favorable environment. The improves microbial adherence delivering chemical signals or generating microenvironments. Microorganisms use this coating nutrient source. gathers both inorganic organic substances from its surroundings, these are generated microbes These nutrients boost initial adhering facilitate formation acting food Coatings with combined antibacterial efficacy antifouling properties provide further benefits preventing dead cells debris surfaces. In present review, we address numerous that form surfaces biomedical devices. addition, explore several efficient smart antiadhesive coatings device-relevant materials manage caused biofilm-forming

Язык: Английский

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Disruption of Communication: Recent Advances in Antibiofilm Materials with Anti-Quorum Sensing Properties

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(11), С. 13353 - 13383

Опубликована: Март 11, 2024

Biofilm contamination presents a significant threat to public health, the food industry, and aquatic/marine-related applications. In recent decades, although various methods have emerged combat biofilm contamination, intricate persistent nature of biofilms makes complete eradication challenging. Therefore, innovative alternative solutions are imperative for addressing formation. Instead solely focusing on mature biofilms, strategically advantageous measures involve delay or prevention formation surfaces. Quorum sensing, communication system enabling bacteria coordinate their behavior based population density, plays pivotal role in numerous microbial species. Materials possessing antibiofilm properties that target quorum sensing gained considerable attention potential prevent This Review consolidates research progress utilization materials with antiquorum combating These can be categorized into three distinct types: (i) nanomaterials, (ii) surfaces, (iii) hydrogels capabilities. Finally, concludes brief discussion current challenges outlines avenues future research.

Язык: Английский

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Superhydrophobic photothermal coatings based on candle soot for prevention of biofilm formation

Journal of Material Science and Technology, Год журнала: 2022, Номер 132, С. 18 - 26

Опубликована: Июнь 22, 2022

Язык: Английский

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Improvement of Antibacterial and Antifouling Properties of a Cellulose Acetate Membrane by Surface Grafting Quaternary Ammonium Salt

ACS Applied Materials & Interfaces, Год журнала: 2022, Номер 14(33), С. 38358 - 38369

Опубликована: Авг. 11, 2022

Through etherification reaction, epoxy propyl dimethyl dodecyl ammonium chloride (EPDMDAC) was grafted onto the surface of a cellulose acetate (CA) membrane to prepare stable nonleaching antibacterial antifouling (QCA-X). The results showed that with extension grafting reaction time, quaternary salt groups on increased and hydrophilicity enhanced. Compared those CA membrane, filtration capacity performance QCA-X are improved. When time is 4 h, water permeability flux recovery rate QCA-4 by 139 21.5%, respectively. excellent performance, sterilization against S. aureus E. coli more than 99.99%. After four repeated cycles, bactericidal rates were maintained at about 99.69 ± 0.02 99.98 0.02%, respectively, good persistence. Moreover, can effectively inhibit bacterial adhesion. Mild simple EPDMDAC modifications improve antibacterial, antifouling, antibioadhesion properties showing its application potential in long-term treatment, especially biofouling treatment.

Язык: Английский

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Three lines of defense: A multifunctional coating with anti-adhesion, bacteria-killing and anti-quorum sensing properties for preventing biofilm formation of Pseudomonas aeruginosa

Acta Biomaterialia, Год журнала: 2022, Номер 151, С. 254 - 263

Опубликована: Авг. 9, 2022

Язык: Английский

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