Viruses,
Год журнала:
2022,
Номер
14(9), С. 1900 - 1900
Опубликована: Авг. 27, 2022
It
is
generally
accepted
that
certain
viral
infections
can
trigger
the
development
of
autoimmune
diseases.
However,
exact
mechanisms
by
which
these
viruses
induce
autoimmunity
are
still
not
understood.
In
this
review,
we
first
describe
hypothetical
some
representative
Then,
focus
on
Epstein–Barr
virus
(EBV)
and
discuss
its
role
in
pathogenesis
rheumatoid
arthritis
(RA).
The
discussion
mainly
based
our
own
previous
findings
(A)
EBV
DNA
products
EBV-encoded
small
RNA
(EBER)
latent
membrane
protein
1
(LMP1)
present
synovial
lesions
RA,
(B)
mRNA
expression
signaling
lymphocytic
activation
molecule-associated
(SAP)/SH2D1A
gene
plays
a
critical
cellular
immune
responses
to
reduced
peripheral
T
cells
patients
with
(C)
infection
mice
reconstituted
human
system
components
(humanized
mice)
induced
erosive
pathologically
similar
RA.
Additionally,
environmental
factors
may
contribute
reactivation
as
follows:
Porphyromonas
gingivalis
peptidylarginine
deiminase
(PAD),
an
enzyme
required
for
citrullination,
engenders
antigens
leading
production
citrullinated
peptides
both
gingiva
synovium.
Anti-citrullinated
autoantibody
important
marker
diagnosis
disease
activity
These
findings,
well
various
results
obtained
other
researchers,
strongly
suggest
directly
involved
typical
disease.
Biology,
Год журнала:
2023,
Номер
12(10), С. 1334 - 1334
Опубликована: Окт. 14, 2023
Since
the
discovery
of
microRNAs
(miRNAs)
in
C.
elegans
1993,
field
miRNA
research
has
grown
steeply.
These
single-stranded
non-coding
RNA
molecules
canonically
work
at
post-transcriptional
phase
to
regulate
protein
expression.
miRNAs
are
known
viral
infection
and
ensuing
host
immune
response.
Evolving
suggests
assets
investigation
therapeutics
diagnostics.
In
this
review,
we
succinctly
summarize
latest
findings
(i)
mechanisms
underpinning
regulation
infection,
(ii)
response
pathogens,
(iii)
miRNA-based
diagnostics
targeting
pathogens
challenges,
(iv)
patents
market
landscape.
Our
show
differential
expression
may
serve
as
a
prognostic
biomarker
for
infections
regard
predicting
severity
or
adverse
health
effects
associated
with
diseases.
While
there
is
huge
potential
technology,
novel
approach
using
mimics
enhance
antiviral
activity
antagonists
inhibit
pro-viral
been
an
ongoing
endeavor.
Significant
hurdles
remain
terms
delivery,
stability,
efficacy,
safety/tolerability,
specificity.
Addressing
these
challenges
pave
path
harnessing
full
modern
medicine.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Июль 8, 2024
Exosome-derived
microRNAs
(miRNAs)
are
biomacromolecules
and
nanoscale
extracellular
vesicles
originating
from
intracellular
compartments
that
secreted
by
most
cells
into
the
space.
This
review
examines
formation
function
of
exosomal
miRNAs
in
biological
information
transfer,
explores
pathogenesis
vitiligo,
highlights
relationship
between
vitiligo.
The
aim
is
to
deepen
understanding
how
influence
immune
imbalance,
oxidative
stress
damage,
melanocyte-keratinocyte
interactions,
melanogenesis
disorders
development
enhanced
may
contribute
potential
diagnostic
therapeutic
options
for
Clinical and Experimental Medicine,
Год журнала:
2024,
Номер
24(1)
Опубликована: Сен. 11, 2024
Abstract
Inflammatory
bowel
disease
(IBD)
is
a
persistent
inflammatory
illness
of
the
gastrointestinal
tract
(GIT)
triggered
by
an
inappropriate
immune
response
to
environmental
stimuli
in
genetically
predisposed
persons.
Unfortunately,
IBD
patients'
quality
life
negatively
impacted
symptoms
associated
with
disease.
The
exact
etiology
pathogenesis
not
fully
understood,
but
emerging
research
indicated
that
microRNA
(miRNA)
plays
important
role.
miRNAs
have
been
documented
possess
significant
role
regulating
pro-
and
anti-inflammatory
pathways,
addition
their
roles
several
physiological
processes,
including
cell
growth,
proliferation,
apoptosis.
Variations
miRNA
profiles
might
be
helpful
prognostic
indicator
valuable
tool
differential
diagnosis
IBD.
Most
interestingly,
these
promising
therapeutic
target
pre-clinical
animal
studies
phase
2
clinical
alleviate
inflammation
improve
patient's
life.
This
comprehensive
review
discusses
current
knowledge
about
different
health
intestinal
system
addresses
most
relevant
differentially
expressed
IBD,
identify
potential
targets,
emphasize
diagnostic
for
future
research.
Biomedicine & Pharmacotherapy,
Год журнала:
2022,
Номер
148, С. 112760 - 112760
Опубликована: Фев. 25, 2022
Glioblastoma
(GB)
is
a
highly
aggressive
cancer
of
the
central
nervous
system,
occurring
in
brain
or
spinal
cord.
Many
factors
such
as
angiogenesis
are
associated
with
GB
development.
Angiogenesis
procedure
by
which
pre-existing
blood
vessels
create
new
that
play
an
essential
role
health
and
disease,
including
tumors.
Also,
one
significant
thought
to
be
responsible
for
treatment
resistance
many
tumors,
GB.
Hence,
improved
understanding
molecular
processes
underlying
will
pave
way
developing
potential
treatments.
Recently,
it
has
been
found
microRNAs
(miRNAs)
exosomal
miRNAs
have
crucial
inducing
inhibiting
process
A
better
knowledge
miRNA's
regulation
pathway
offers
unique
mechanistic
insight
into
mechanism
tumor-associated
neovascularization.
Because
advancements
miRNA
characterization
delivery
methods,
can
also
employed
clinical
settings
biomarkers
anti-angiogenic
response
well
therapies
targeting
tumor
angiogenesis.
The
recent
finding
insights
about
miRNAs'
angioregulatory
provided
throughout
review.
we
discuss
concept
miRNAs-based
future.
Viruses,
Год журнала:
2022,
Номер
14(9), С. 1900 - 1900
Опубликована: Авг. 27, 2022
It
is
generally
accepted
that
certain
viral
infections
can
trigger
the
development
of
autoimmune
diseases.
However,
exact
mechanisms
by
which
these
viruses
induce
autoimmunity
are
still
not
understood.
In
this
review,
we
first
describe
hypothetical
some
representative
Then,
focus
on
Epstein–Barr
virus
(EBV)
and
discuss
its
role
in
pathogenesis
rheumatoid
arthritis
(RA).
The
discussion
mainly
based
our
own
previous
findings
(A)
EBV
DNA
products
EBV-encoded
small
RNA
(EBER)
latent
membrane
protein
1
(LMP1)
present
synovial
lesions
RA,
(B)
mRNA
expression
signaling
lymphocytic
activation
molecule-associated
(SAP)/SH2D1A
gene
plays
a
critical
cellular
immune
responses
to
reduced
peripheral
T
cells
patients
with
(C)
infection
mice
reconstituted
human
system
components
(humanized
mice)
induced
erosive
pathologically
similar
RA.
Additionally,
environmental
factors
may
contribute
reactivation
as
follows:
Porphyromonas
gingivalis
peptidylarginine
deiminase
(PAD),
an
enzyme
required
for
citrullination,
engenders
antigens
leading
production
citrullinated
peptides
both
gingiva
synovium.
Anti-citrullinated
autoantibody
important
marker
diagnosis
disease
activity
These
findings,
well
various
results
obtained
other
researchers,
strongly
suggest
directly
involved
typical
disease.
