Brain Behavior and Immunity, Год журнала: 2024, Номер unknown
Опубликована: Дек. 1, 2024
Язык: Английский
Cell, Год журнала: 2024, Номер 187(15), С. 4043 - 4060.e30
Опубликована: Июнь 14, 2024
Inflammation-induced neurodegeneration is a defining feature of multiple sclerosis (MS), yet the underlying mechanisms remain unclear. By dissecting neuronal inflammatory stress response, we discovered that neurons in MS and its mouse model induce stimulator interferon genes (STING). However, activation STING requires detachment from stromal interaction molecule 1 (STIM1), process triggered by glutamate excitotoxicity. This initiates non-canonical signaling, which leads to autophagic degradation glutathione peroxidase 4 (GPX4), essential for redox homeostasis thereby inducing ferroptosis. Both genetic pharmacological interventions target protect against inflammation-induced neurodegeneration. Our findings position as central regulator detrimental integrating inflammation with signaling cause cell death, present it tractable treating MS.
Язык: Английский
Процитировано
40
Nature reviews. Neuroscience, Год журнала: 2024, Номер 25(7), С. 493 - 513
Опубликована: Май 24, 2024
Язык: Английский
Процитировано
38
PLoS Pathogens, Год журнала: 2024, Номер 20(5), С. e1011820 - e1011820
Опубликована: Май 8, 2024
The production of IFN-γ is crucial for control multiple enteric infections, but its impact on intestinal epithelial cells (IEC) not well understood. Cryptosporidium parasites exclusively infect and the ability interferons to activate transcription factor STAT1 in IEC required parasite clearance. Here, use single cell RNA sequencing profile during infection revealed an increased proportion mid-villus enterocytes induction IFN-γ-dependent gene signatures that was comparable between uninfected infected cells. These analyses were complemented by vivo studies, which demonstrated expression receptor control. Unexpectedly, treatment Ifng -/- mice with showed response this cytokine correlates a delayed reduction burden did affect development. data sets provide insight into suggest model signalling important .
Язык: Английский
Процитировано
8
Frontiers in Psychiatry, Год журнала: 2024, Номер 15
Опубликована: Апрель 25, 2024
Autism spectrum disorder (ASD) is a neurodevelopmental that encompasses range of symptoms including difficulties in verbal communication, social interaction, limited interests, and repetitive behaviors. Neuroplasticity refers to the structural functional changes occur nervous system adapt respond external environment. In simpler terms, it brain's ability learn new environments. However, individuals with ASD exhibit abnormal neuroplasticity, which impacts information processing, sensory cognition, leading manifestation corresponding symptoms. This paper aims review current research progress on focusing genetics, environment, neural pathways, neuroinflammation, immunity. The findings will provide theoretical foundation insights for intervention treatment pediatric fields related ASD.
Язык: Английский
Процитировано
6
Brain Behavior and Immunity, Год журнала: 2023, Номер 115, С. 458 - 469
Опубликована: Ноя. 3, 2023
The gut microbiome consists of trillions bacteria, fungi, and viruses that inhabit the digestive tract. These communities are sensitive to disruption from environmental exposures ranging diet changes illness. Disruption community lactic acid producing Lactobaccillacea, has been well documented in mood disorders stress exposure. In fact, oral supplement with many Lactobacillus species can ameliorate these effects, preventing depression- anxiety-like behavior. Here, we utilize a gnotobiotic mouse colonized Altered Schaedler Flora remove two native Lactobaccillacea: L. intestinalis murinus. Using this microbial community, found themselves, not disrupted protective stressors. Further, determine Lactobaccillacea maintaining homeostatic IFNγ levels which mediating behavioral circuit level responses. By utilizing Flora, have gained new insight into how probiotics influence behavior provide novel methods study potential therapies treat disorders.
Язык: Английский
Процитировано
11
Frontiers in Microbiology, Год журнала: 2024, Номер 15
Опубликована: Июнь 10, 2024
Neuropathic pain (NP) is characterized by its complex and multifactorial nature limited responses to opioid therapy; NP associated with risks of drug resistance, addiction, difficulty in treatment cessation, psychological disorders. Emerging research on gut microbiota their metabolites has demonstrated effectiveness alleviating augmenting opioid-based management, concurrently mitigating the adverse effects opioids. This review addresses following key points: (1) current advances challenges using opioids treat NP, (2) reciprocal benefits (3) interaction between microbiota, as well NP. Through various intricate mechanisms, influences onset progression ultimately enhancing efficacy management These insights pave way for further pragmatic clinical research, management.
Язык: Английский
Процитировано
4
Nature, Год журнала: 2025, Номер unknown
Опубликована: Май 28, 2025
Язык: Английский
Процитировано
0
Brain Behavior and Immunity, Год журнала: 2024, Номер 124, С. 1 - 8
Опубликована: Ноя. 13, 2024
Язык: Английский
Процитировано
1
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown
Опубликована: Ноя. 16, 2023
The production of IFN-γ is crucial for control multiple enteric infections, but its impact on intestinal epithelial cells (IEC) not well understood.
Язык: Английский
Процитировано
1
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Июль 27, 2024
Neonatal pain is a significant clinical issue but the mechanisms by which produced early in life are poorly understood. Our recent work has linked transcription factor serum response downstream of local growth hormone (GH) signaling to incision-related hypersensitivity neonates. However, it remains unclear if similar contribute inflammatory We found that GH treatment inhibited neonatal myalgia appeared do so through unique signal transducer and activator (STAT) dependent pathway within sensory neurons. The STAT1 regulate peripheral inflammation itself modulation monocyte chemoattractant protein 1 (MCP1) release from Data suggests upregulation, signaling, contributes nociception during muscle novel neuroimmune loop involving cytokine primary afferents. Results could uncover new ways treat
Язык: Английский
Процитировано
0